Skip to main content
Log in

Biliary Tract Tuberculosis—a Diagnostic Dilemma

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Introduction

Most western patients who have not had a previous operation and present with biliary obstruction are thought to have a malignant lesion. However in our country where the disease is common, we found that some of these patients had a tuberculous cause which considerably altered their management as well as their prognosis. We herein present our experience of these patients whom we had operated with a preoperative diagnosis of biliary tract malignancy and discuss, retrospectively, how they might have been detected before operation to have tuberculosis.

Methods

Between August 1996 and June 2010, we operated on 209 patients with a preoperative diagnosis of carcinoma of the gallbladder and common bile duct. Seven out of these 209 patients had biliary tuberculosis. We retrospectively analyzed the clinical features of these patients from our prospectively maintained database.

Results

There were four males and three females who had a mean age of 54 (32–65) years. The bile duct was involved in four and gallbladder in three patients. In contrast to those with malignancy, patients with tuberculosis had a longer history (122 vs 44 days), an abdominal mass was present less frequently (28% vs 57%), the serum bilirubin was lower (1.6 vs 6 mg/dl), and they also had evidence of tuberculosis elsewhere in the body (28.5%). There was no operative mortality in biliary tract tuberculosis in contrast to 7.5% in biliary tract malignancy.

Conclusion

Though tuberculosis of the biliary tract is rare, it needs to be considered in the differential diagnosis of patients with biliary obstruction especially in countries where the disease is endemic.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

References

  1. Amarapurkar DN, Patel ND, Amarapurkar AD. Hepatobiliary tuberculosis in western India. Indian J Pathol Microbiol 2008;51:175–181.

    Article  PubMed  Google Scholar 

  2. Alvarez SZ, carpio R. Hepatobiliary tuberculosis. Dig Dis Sci 1983;28:193–200.

    Article  PubMed  CAS  Google Scholar 

  3. Maher D, Chaulet P, Spinaci S, Harries A. Treatment of tuberculosis: Guidelines for national programs. WHO Global tuberculosis program. WHO/TB/97;220.

  4. Leder RA, Low VHS. Tuberculosis of the abdomen. Radiol Clin N Am 1995;33:691–705.

    PubMed  CAS  Google Scholar 

  5. Yeh TS, Chen NH, Jan YY, Hwang TL, Jeng LB, Chen MF. Obstructive jaundice caused by biliary tuberculosis: Spectrum of the diagnosis and management. Gastrointest Endosc 1999;50:105–108.

    Article  PubMed  CAS  Google Scholar 

  6. Murphy TF, Gray GF. Biliary tract obstruction due to tuberculous adenitis. Am J Med 1980; 68:452–454.

    Article  PubMed  CAS  Google Scholar 

  7. Miyamoto S, Furuse J, Maru Y, Tajiri H, Muto M, Yoshino M. Duodenal tuberculosis with a choledocho-duodenal fistula. J Gastroenterol Hepatol 2001; 16:235–238.

    Article  PubMed  CAS  Google Scholar 

  8. Behera A, Kochhar R, Dhavan S, Aggarwal S, Singh K. Isolated common bile duct tuberculosis mimicking malignant obstruction. Am J Gastroenterol 1997;92: 2122–2123.

    PubMed  CAS  Google Scholar 

  9. Fan ST, Ng IO, Choi TK, Lai EC. Tuberculosis of the bile duct: a rare cause of biliary stricture. Am J Gastroenterol 1989;84:413–414.

    PubMed  CAS  Google Scholar 

  10. Khosla SN, Chhabra HK, Mehrotra GC. Liver in abdominal tuberculosis. J Assoc Physicians India 1986;34:501–502.

    PubMed  CAS  Google Scholar 

  11. Maharaj B, Leary WP, Pudifin DJ. A prospective study of hepatic tuberculosis in 41 black patients. Q J Med 1987;63:517–522.

    PubMed  CAS  Google Scholar 

  12. Chen CH, Yang CC, Yeh YH, et al. Pancreatic tuberculosis with obstructive jaundice—a case report. Am J Gastroenterol 1999;94(9):2534–2536.

    PubMed  CAS  Google Scholar 

  13. Hulnick DH, Megibow AJ, Naidich DP, et al. Abdominal tuberculosis: CT evaluation. Radiology 1985;157(1):199–204.

    PubMed  CAS  Google Scholar 

  14. Bhansali SK. Abdominal tuberculosis. Experiences with 300 cases. Am J Gastroenterol 1977; 67(4):324–337.

    PubMed  CAS  Google Scholar 

  15. Saluja SS, Ray S, Pal S, et al. Hepatobiliary and pancreatic tuberculosis: a two decade experience. BMC Surg 2007; 7:10.

    Article  PubMed  Google Scholar 

  16. Chong VH, Lim KS. Hepatobiliary tuberculosis. Singapore Med J 2010;51(9):744–751.

    PubMed  CAS  Google Scholar 

  17. Varma V, Gupta S, Soin AS, Nundy. Does the presence of jaundice and/or a lump in a patient with gall bladder cancer mean that the lesion is not resectable? Dig Surg 2009;26:306–311.

    Article  PubMed  Google Scholar 

  18. Stemmerman M. Bile duct tuberculosis. Q Bull Sea View Hosp 1941;6:316–24.

    Google Scholar 

  19. Kok KY, Yap SK. Tuberculosis of the bile duct: a rare cause of obstructive jaundice. J Clin Gastroenterol 1999;29:161–164.

    Article  PubMed  CAS  Google Scholar 

  20. Bearer EA, Savides TJ, McCutchan JA. Endoscopic diagnosis and management of hepatobiliary tuberculosis. Am J Gastroenterol 1996;91:2602–2604.

    PubMed  CAS  Google Scholar 

  21. Alcantara-Payawal DE, Matsumura M, Shiratori Y, Okudaira T, Sollano JD, Omata M. Direct detection of Mycobacterium tuberculosis using polymerase chain reaction assay among patients with hepatic granuloma. J Hepatol 1997;27: 620–627.

    Article  PubMed  CAS  Google Scholar 

  22. Inal M, Aksungur E, Akgul E, Demirbas O, Oguz M, Erkocak E. Biliary tuberculosis mimicking cholangiocarcinoma: treatment with metallic biliary endoprothesis. Am J Gastroenterol 2000;95:1069–1071.

    Article  PubMed  CAS  Google Scholar 

  23. Mallery JS, Centeno BA, Hahn PF, Chang Y, Warshaw AL, Brugge WR. Pancreatic tissue sampling guided by EUS, CT/US, and surgery: a comparison of sensitivity and specificity. Gastrointest Endosc 2002;56:218–224.

    Article  PubMed  Google Scholar 

  24. Breen RA, Smith CJ, Bettinson H, et al. Paradoxical reactions during tuberculosis treatment in patients with and without HIV co-infection. Thorax 2004;59:704–707.

    Article  PubMed  CAS  Google Scholar 

  25. Cheng VC, Ho PL, Lee RA, et al. Clinical spectrum of paradoxical deterioration during antituberculosis therapy in non-HIV-infected patients. Eur J Clin Microbiol Infect Dis 2002;21:803–809.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We acknowledge Dr. Sunita Bhalla and Dr. Fouzia Siraj, department of pathology for the pictures of histopathological examination.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Mahendran Govindasamy.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Govindasamy, M., Srinivasan, T., Varma, V. et al. Biliary Tract Tuberculosis—a Diagnostic Dilemma. J Gastrointest Surg 15, 2172–2177 (2011). https://doi.org/10.1007/s11605-011-1685-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11605-011-1685-5

Keywords

Navigation