Abstract
Background
There are little data regarding the impact of depression on outcomes after gastrointestinal surgery. We hypothesize that depression would be associated with prolonged hospital stay and changes in discharge disposition for patients undergoing colon and rectal surgery.
Methods
We identified 292,191 patients undergoing colon and rectal surgery using the 2008 Nationwide Inpatient Sample. We used multivariate regression to evaluate the effect of depression on length of stay and discharge disposition.
Results
A preoperative diagnosis of depression was present in 20,039 (6.9%) patients. Mean length of stay for those with depression (10.4 days, 95% confidence interval (CI) 10.04–10.76) was significantly longer than for patients without depression (9.64 days, 95% CI 9.48–9.81). After adjusting for cofounders, depression still predicted an increase in length of stay. Additionally, depressed patients were less likely to resume normal function at discharge, as 40% required either home health or time in a skilled facility following discharge from the acute care hospital.
Conclusions
Among patients undergoing colorectal surgery, depression is associated with a significantly prolonged hospital stay and higher likelihood of requiring skilled nursing assistance after discharge. Further research into the mechanism underlying these differences and potential treatment strategies among depressed patients is warranted.
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References
Andrade L, Caraveo-Anduaga JJ, Berglund P, et al. The epidemiology of major depressive episodes: results from the International Consortium of Psychiatric Epidemiology (ICPE) Surveys. Int J Methods Psychiatr Res. 2003;12(1):3–21
Donohue JM, Pincus HA. Reducing the societal burden of depression: a review of economic costs, quality of care and effects of treatment. Pharmacoeconomics. 2007;25(1):7–24
Gehi AK, Ali S, Na B, et al. Self-reported medication adherence and cardiovascular events in patients with stable coronary heart disease: the Heart and Soul Study. Arch Intern Med. 2005;165(2):2508–2513
Ruo B, Rumsfeld JS, Hltatky M,et al. Depressive symptoms and health-related quality of life: the Heart and Soul Study. JAMA. 2003;290(2):215–221
Frasure-Smith N, Lesperance F, Talajic M. Depression following myocardial infarction: impact on 6-month survival. JAMA. 1993;270(15):1819–1825
Litchman JH, Bigger JT Jr, Blumenthal JA, et al. Depression and coronary heart disease: recommendations for screening, referral and treatment. A science advisory from the American Heart Association Prevention Committee of the Council on Cardiovascular Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Interdisciplinary Council on Quality of Care and Outcomes Research: endorsed by the American Psychiatric Association. Circulation. 2008;118(17):1768–1775
Everson-Rose SA, Meyer PM, Powell LH, et al. Depressive symptoms, insulin resistance, and risk of diabetes in women at midlife. Diabetes Care. 2004;27(12):2856–2862
Eaton WW, Armenian H, Gallo J, et al. Depression and risk for onset of type II diabetes: a prospective population-based study. Diabetes Care. 1996;19(10):1097–1102
Kawakami N, Takatsuka N, Shimizu H, et al. Depressive symptoms and occurrence of type 2 diabetes among Japanese men. Diabetes Care. 1999;22(7):1071–1076
Carnethon MR, Kinder LS, Fair JM, et al. Symptoms of depression as a risk factor for incident diabetes: findings from the National Health and Nutrition Examination Epidemiologic follow-up study, 1971–1992. Am J Epidemiol. 2003;158(5):416–23
Arroyo C, Hu FB, Ryan LM, et al. Depressive symptoms and risk of type 2 diabetes in women. Diabetes Care. 2004;27(1):129–133
Marcus MD, Wing RR, Guare J, et al.. Lifetime prevalence of major depression and its effect on treatment outcome in obese type II diabetic patients. Diabetes Care. 1992;15(2):253–255
Ciechanowski PS, Katon WJ, Russo JE. Depression and diabetes: impact of depressive symptoms on adherence, function, and costs. Arch Intern Med. 2000;160(21):3278–328
de Groot M, Anderson R, Freedland KE, et al. Association of depression and diabetes complications: a meta-analysis. Psychosom Med. 2001;63(4):619–630
Jonas BS, Mussolino M. Symptoms of depression as a prospective risk factor for stroke. Psychosomatic Medicine. 2000;62(4):463–471
Kauhanen M, Korpelainen JT, Hiltunen P, et al. Poststroke depression correlates with cognitive impairment and neurological deficits. Stroke. 1999;30(9):1875–80
Sinyor D, Amato P, Kaloupek DG, et al. Post-stroke depression: relationships to functional impairment, coping strategies and rehabilitation outcome. Stroke. 1986;17(6):1102–7
Kimmel PL, Peterson RA, Weihs KL et al. Multiple measurements of depression predict mortality in a longitudinal study of chronic hemodialysis patients. Kidney Int. 2000;57:2093–2098
Burton HJ, Kline SA, Lindsay RM, et al. The relationship of depression to survival in chronic renal failure. Psychosom Med. 1986;48(3–4):261–9
Herrmann C, Brand-Driehorst S, Kaminsky B, et al. Diagnostic groups and depressed mood as predictors of 22-month mortality in medical inpatients. Psychosom Med. 1998;60(5):570–7
Covinsky KE, Kahana E, Chin MH, et al. Depressive symptoms and 3-year mortality in older hospitalized patients. Ann Intern Med. 1999;130(7):563–9
Kadoi Y, Kawauchi C, Ide M, et al. Preoperative depression is a risk factor for postoperative short-term and long-term cognitive dysfunction in patients with diabetes mellitus. J Anesth. 2011;25(1):10–7
Beresnevaite M, Benetis R, Taykir GJ, et al. Depression predicts perioperative outcomes following coronary artery bypass graft surgery. Scand Cardiovasc J. 2010;44(5):289–94
Kendel F, Gelbrich G, Wirtz M, et al. Predictive relationship between depression and physical functioning after coronary surgery. Arch Intern Med. 2010;170(19):1717–21
Dao TK, Chu D, Springer J, et al. Depression and geographic status as predictors for coronary artery bypass surgery outcomes. J Rural Health. 2010;26(1):36–43
Phillips-Bute B, Mathew JP, Blumenthal JA, et al. Relationship of genetic variability and depressive symptoms to adverse events after coronary artery bypass graft surgery. Psychosom Med. 2008;70(9):953–9
Mallik S, Krumholz HM, Lin ZQ, et al. Patients with depressive symptoms have lower health status benefits after coronary artery bypass surgery. Circulation. 2005;111(3):271–7
Burg MM, Benedetto MC, Rosenberg R, et al. Presurgical depression predicts medical morbidity 6 months after coronary artery bypass graft surgery. Psychosom Med. 2003;65(1):111–8
Overview of the NIS. Available at: http://www.hcup-us.ahrq.gov/nisoverview.jsp. Accessed November 1, 2010
Elixhauser A, Steiner C, Harris DR, Coffey RM. Comorbidity measures for use with administrative data. Med Care. 1998;36(1):8–27
Deyo RA, Cherkin DC, Ciol MA. Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol. 1992;45(6):613–619
Davidson, G. H., Hamlat, C. A., Rivara, F. P., Koepsell, T. D., Jurkovich, G. J. and Arbabi, S. Long-term survival of adult trauma patients. JAMA. 2011;305:1001–1007
Kroenke K, Spitzer K, Williams JB. The Patient Health Questionnaire-2: validity of a two-item depression screener. Med Care. 2003;41(11):1284–92
Kendel F, Wirtz M, Dunkel A, et al. Screening for depression: Rasch analysis of the dimensional structure of the PHQ-9 and the HADS-D. J Affect Disord. 2010;122(3):241–6
Dunkel A, Kendel F, Lehmkuhl E, et al. Predictors of preoperative depressive risk in patients undergoing coronary artery bypass graft surgery. Clin Res Cardiol. 2009;98(10):643–50
Kim DH, Daskalakis C, Whellan DJ, et al. Safety of selective serotonin reuptake inhibitor in adults undergoing coronary artery bypass grafting. Am J Cardiol. 2009;103(10):1391–5
Lindsay GM, Hanlon P, Hutton I, et al. A nurse-led intervention reduced risk factors, anxiety, and depression in patients waiting for CABG. Heart 2001;86:317–323
Furze G, Dumville JC, Miles JN, et al. “Prehabilitation” prior to CABG surgery improves physical functioning and depression. Int J Cardiol. 2009;132(1):51–8
Acknowledgments
The authors acknowledge financial support and/or resources in the preparation of this manuscript from the Houston Health Services Research and Development Center of Excellence (HF P90-020) at the Michael E. DeBakey VA Medical Center. Dr. Naik receives additional support from the National Institute on Aging (K23AG027144) and a Doris Duke Charitable Foundation Clinical Scientist Development Award. Dr. Robinson received support from a Baylor College of Medicine Comprehensive Cancer Training Program Grant (CPRIT RP 101499). These sources had no role in the preparation, review, or approval of the manuscript. The views expressed in this article are those of the authors and do not necessarily represent the views of the Department of Veterans Affairs. The authors had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
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Courtney J. Balentine and Jesus Hermosillo-Rodriguez are co-first authors.
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Balentine, C.J., Hermosillo-Rodriguez, J., Robinson, C.N. et al. Depression Is Associated with Prolonged and Complicated Recovery Following Colorectal Surgery. J Gastrointest Surg 15, 1712–1717 (2011). https://doi.org/10.1007/s11605-011-1640-5
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DOI: https://doi.org/10.1007/s11605-011-1640-5