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Primary Colorectal Lymphoma—Clinical Outcomes in a Population-Based Series

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Purpose

The purpose of this study was to investigate the characteristics and the outcomes of primary colorectal lymphomas using a population-based registry.

Methods

All cases of colorectal lymphoma diagnosed between 1980 and 2007 were identified using a provincial cancer registry. Patients meeting Dawson’s criteria and having a negative bone marrow biopsy were included.

Results

One hundred ten cases of colorectal lymphoma were identified, 43 met the inclusion criteria. The majority of patients was male (86%), and the median age at diagnosis was 62 (range 26–82) years. Tumors were mostly located in the cecum (51.1%) and rectum (20.9%). The 5-year overall survival rate calculated by the Kaplan–Meier method was 57%. Age under 60 was associated with a better median survival time (265 vs 54 months; p < 0.0001). The surgical treatment was associated with a better overall survival compared to medical treatment alone (110 vs 56 months; p = 0.083). Tumors located in the rectum were associated with a decreased overall survival (41 months vs 110 months; p = 0.065).

Conclusions

Primary colorectal lymphoma is a rare disease. The age at diagnosis is an important predictor of outcome. Surgical resection may be associated with improved survival. Rectal lymphoma appears to be associated with a worse outcome and may warrant more aggressive therapy.

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No conflicts of interest exist.

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Authors and Affiliations

  1. Department of Surgery, University of Calgary, Calgary, AB, Canada

    Sebastien Drolet, Anthony R. Maclean, Elijah Dixon, Elizabeth Oddone Paolucci & W. Donald Buie

  2. Department of Oncology and Medicine, University of Calgary, Calgary, AB, Canada

    Douglas A. Stewart

  3. 1009 North Tower, Foothill Medical Center, 1403-29 street NW, Calgary, AB, Canada, T2N 2T9

    W. Donald Buie

Authors
  1. Sebastien Drolet
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  2. Anthony R. Maclean
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  3. Douglas A. Stewart
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  4. Elijah Dixon
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  5. Elizabeth Oddone Paolucci
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  6. W. Donald Buie
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Corresponding author

Correspondence to W. Donald Buie.

Additional information

Poster Presentation

This study was included as a poster presentation during the ASCRS Annual Meeting on May 15–19, 2010 at Minneapolis, MN, USA.

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Drolet, S., Maclean, A.R., Stewart, D.A. et al. Primary Colorectal Lymphoma—Clinical Outcomes in a Population-Based Series. J Gastrointest Surg 15, 1851–1857 (2011). https://doi.org/10.1007/s11605-011-1572-0

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  • DOI: https://doi.org/10.1007/s11605-011-1572-0

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