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Analysis of Factors Associated with Prognosis After Colorectal Cancer Resection in 174 Chinese Elderly Patients

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Purpose

The purpose of the present study was to investigate risk factors associated with prognosis in elderly patients with colorectal cancer (CRC) and to determine treatment and follow-up strategies.

Materials and Methods

CRC patients (age ≥70) who were treated with curative operation were studied. We compared 57 patients whose survival time was less than 2 years with 117 patients with survival time exceeding 5 years, based on the clinical, pathologic, and preoperative clinical laboratory analysis findings. A risk scoring system on basis of factors determined by multiple logistic regression analysis was explored and validated by both receiver operating characteristic and survival analysis.

Results

Neuroticism, rural residence, deep layer invasion, lymphovascular invasion, and high serum CEA levels were found to be associated with adverse prognosis in the multivariate logistic regression model. Risk scoring system based on these factors showed that the patients with total score exceeding 2.5 had a significantly poorer prognosis (P < 0.05), which was validated by survival analysis.

Conclusions

Patients with neuroticism, rural residence, deep layer invasion, lymphovascular invasion, and high serum CEA level should be regarded as a high-risk group; a simple scoring system based on these factors could be used to evaluate the risk and facilitate treatment of CRC for elderly patients.

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Acknowledgements

This study was supported by Shanghai Science and Technology Committee [No.07dz19505].

Conflict of Interest

None.

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Authors and Affiliations

  1. Department of Abdominal Surgery, The Affiliated Tumor Hospital, Harbin Medical University, Harbin, 150086, China

    Zheng Jiang, Xishan Wang & Sanjun Cai

  2. Department of Colorectal Surgery, Cancer Hospital, Fudan University, 270 Dong An Road, Shanghai, 200032, China

    Zheng Jiang, Ye Xu & Sanjun Cai

  3. Department of medical genetics, Harbin Medical University, Harbin, 150086, China

    Chunxiang Li

  4. Department of Medical Psychology, Harbin Medical University, Harbin, 150086, China

    Xiaohui Qiu

Authors
  1. Zheng Jiang
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  2. Chunxiang Li
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  3. Xiaohui Qiu
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  4. Ye Xu
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  5. Xishan Wang
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  6. Sanjun Cai
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Correspondence to Sanjun Cai.

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Jiang, Z., Li, C., Qiu, X. et al. Analysis of Factors Associated with Prognosis After Colorectal Cancer Resection in 174 Chinese Elderly Patients. J Gastrointest Surg 15, 644–651 (2011). https://doi.org/10.1007/s11605-011-1453-6

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  • DOI: https://doi.org/10.1007/s11605-011-1453-6

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