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Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer

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Journal of Gastrointestinal Surgery

Abstract

Background

Although the increased risk of developing pancreatic cancer (PC) in families with a strong history of the disease is well known, characteristics and outcomes of patients with familial PC is not described well.

Aims

This study aims to evaluate outcomes following resection in patients with familial PC.

Methods

We studied 208 patients who underwent resection of PC from 2000 to 2007 and had prospectively completed family history questionnaires for the Biospecimen Resource for Pancreas Research at our institution. We compared clinical characteristics and outcomes of familial and sporadic PC patients.

Results

Familial (N = 15) and sporadic PC patients (N = 193) did not have significantly different demographics, pre-operative CA19-9, pre-operative weight loss, R0 status, or T-staging (all p ≥ 0.05). Familial PC patients had lower pre-operative total serum bilirubin concentrations (p = 0.03) and lesions outside of the pancreatic head more frequently (p = 0.02) than sporadic PC patients. There was no difference in survival at 2 years between familial and sporadic PC patients (p = 0.52).

Conclusions

Familial PC patients appear to develop tumors outside of the pancreatic head more frequently than sporadic PC patients. This difference in tumor distribution may be due to a broader area of cancer susceptibility within the pancreas for familial PC patients.

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Authors and Affiliations

  1. Division of GI and General Surgery, Mayo 12, 200 1st St. SW, Rochester, MN, 55905, USA

    Joshua G. Barton, Thomas Schnelldorfer, John H. Donohue, Michael B. Farnell, Michael L. Kendrick, David M. Nagorney, Kay M. Reid Lombardo & Florencia G. Que

  2. Department of Health Sciences Research, Mayo 12, 200 1st St. SW, Rochester, MN, 55905, USA

    Christine M. Lohse, William R. Bamlet, Kari G. Rabe & Gloria M. Petersen

Authors
  1. Joshua G. Barton
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  2. Thomas Schnelldorfer
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  3. Christine M. Lohse
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  4. William R. Bamlet
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  5. Kari G. Rabe
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  6. Gloria M. Petersen
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  7. John H. Donohue
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  8. Michael B. Farnell
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  9. Michael L. Kendrick
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  10. David M. Nagorney
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  11. Kay M. Reid Lombardo
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  12. Florencia G. Que
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Corresponding author

Correspondence to Florencia G. Que.

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Barton, J.G., Schnelldorfer, T., Lohse, C.M. et al. Patterns of Pancreatic Resection Differ Between Patients with Familial and Sporadic Pancreatic Cancer. J Gastrointest Surg 15, 836–842 (2011). https://doi.org/10.1007/s11605-011-1417-x

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  • DOI: https://doi.org/10.1007/s11605-011-1417-x

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