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Laparoscopic Cardiomyotomy for Achalasia: Clinical Outcomes Beyond 5 Years

Abstract

Background

Laparoscopic cardiomyotomy is the most common surgical procedure for the treatment of achalasia, although few reports describe long-term surgical outcomes.

Methods

The outcomes for 155 patients who underwent a laparoscopic cardiomyotomy with anterior partial fundoplication more than 5 years ago (July 1992 to May 2004) were determined. Patients were followed prospectively at yearly time points using a structured questionnaire which evaluated symptoms of dysphagia, reflux, side-effects, and overall satisfaction with the clinical outcome.

Results

Clinical data were available for 125 patients. Thirteen patients died within 5 years of surgery, four were unable to complete the questionnaire, and one developed esophageal squamous cell carcinoma. Nine patients were lost to follow-up, and three would not answer the questionnaire (92.2% late follow-up). Postoperative dysphagia, odynophagia, chest pain, and heartburn was significantly improved at 1 year, 5 years, and late (5+ years) follow-up, with outcomes stable beyond 12 months. Seventy-seven percent of patients reported a good or excellent result (minimal or no symptoms) at 5 years and 73% at late follow-up. At late follow-up, 90% considered they had made the correct decision to undergo surgery.

Conclusions

At minimum 5 years follow-up, laparoscopic cardiomyotomy for achalasia achieves effective and durable relief of symptoms, and most patients are satisfied with the outcome.

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Figure 1

References

  1. Campos GM, Ciovica R, Takata M. Laparoscopic myotomy. Oper Tech Gen Surg 2006;8:161–169.

    Article  Google Scholar 

  2. Hunter JG, Trus TE, Branum GD, Waring P. Laparoscopic Heller myotomy and fundoplication for achalasia. Ann Surg 1997;225:655–665.

    Article  CAS  PubMed  Google Scholar 

  3. Patti MG, Pellegrini CA, Horgan S, Arcerito M, OMelanczuk P, Tamburini A, Diener U, Eubanks TR, Way LW. Minimally invasive surgery for achalasia: an 8-year experience with 168 patients. Ann Surg 1999;230:587–593.

    Article  CAS  PubMed  Google Scholar 

  4. Ackroyd R, Watson DI, Devitt PG, Jamieson GG. Laparoscopic cardiomyotomy and anterior partial fundoplication for achalasia. Surg Endosc 2001;15(7):683–686.

    Article  CAS  PubMed  Google Scholar 

  5. Johnson LF, DeMeester TR. Twenty-four-hour pH monitoring of the distal esophagus. Am J Gastroenterol 1974;62:325–332.

    CAS  PubMed  Google Scholar 

  6. Ramacciato G, Mercantini P, Amodio PM, Corigliano N, Barreca M, Stipa F, Ziparo V. The laparoscopic approach with antireflux surgery is superior to the thoracoscopic approach for the treatment of esophageal achalasia. Experience of a single surgical unit. Surg Endosc 2002;16:1431–1437.

    Article  CAS  PubMed  Google Scholar 

  7. Raiser F, Perdikis G, Hinder RA, Swanstrom LL, Filipi CJ, McBride PJ, Katada N, Neary PJ. Heller myotomy via minimal-access surgery. An evaluation of antireflux procedures. Arch Surg 1996;131:593–598.

    CAS  PubMed  Google Scholar 

  8. Costantini M, Zaninotto G, Guirroli E, Rizzetto C, Portale G, Ruol A, Nicoletti L, Ancona E. The laparoscopic Heller–Dor operation remains an effective treatment for esophageal achalasia at a minimum 6-year follow-up. Surg Endosc 2005;19(3):345–351

    Article  CAS  PubMed  Google Scholar 

  9. Rossetti G, Brusciano L, Amato G, et al. A total fundoplication is not an obstacle to esophageal emptying after Heller myotomy for achalasia: results of a long-term follow up. Ann Surg 2005;241:614–621.

    Article  PubMed  Google Scholar 

  10. Torquati A, Richards WO, Holzman MD, et al. Laparoscopic myotomy for achalasia: predictors of successful outcome after 200 cases. Ann Surg 2006;243:587–591; discussion 591–593.

    Google Scholar 

  11. Zaninotto G, Costantini M, Rizzetto C, Zanatta L, Guirroli E, Portale G, Nicoletti L, Cavallin F, Battaglia G, Ruol A, Ancona E. Four Hundred Laparoscopic Myotomies for Esophageal Achalasia A Single Centre Experience Ann Surg 2008;248(6):986–993

    Google Scholar 

  12. Ortiz A, de Haro LF, Parrilla P, et al. Very long-term objective evaluation of heller myotomy plus posterior partial fundoplication in patients with achalasia of the cardia. Ann Surg 2008;247:258–264.

    Article  PubMed  Google Scholar 

  13. Csendes A, Braghetto I, Burdiles P, et al. Very late results of esophagomyotomy for patients with achalasia: clinical, endoscopic, histologic, manometric, and acid reflux studies in 67 patients for a mean follow-up of 190 months. Ann Surg 2006;243:196–203.

    Article  PubMed  Google Scholar 

  14. Cowgill SM, Villadolid D, Boyle R, Al-Saadi, Ross S, Rosemurgy AS. Laparoscopic Heller myotomy for achalasia: results after 10 years. Surg Endosc 2009; doi:10.1007/s00464-009-0508-1.

  15. Zaninotto G, Costantini M, Portale G, et al. Etiology, diagnosis, and treatment of failures after laparoscopic Heller myotomy for achalasia. Ann Surg 2002;235:186–192.

    Article  PubMed  Google Scholar 

  16. Mattioli S, Pilotti V, Felice V, Di Simone MP, D'Ovidio F, Gozzetti G. Intraoperative study on the relationship between the lower esophageal sphincter pressure and the muscular components of the gastro-esophageal junction in achalasic patients. Ann Surg 1993;218:635–639.

    Article  CAS  PubMed  Google Scholar 

  17. Oelkschlager BK, Chang L, Pellegrini CA. Improved outcome after extended gastric myotomy for achalasia. Arch Surg 2003;138:490–497

    Article  Google Scholar 

  18. Meijssen MA, Tilanus HW, van Blankenstein M, Hop WC,Ong GL. Achalasia complicated by oesophageal squamous cell carcinoma: a prospective study in 195 patients. Gut 1992;33:155–158.

    Article  CAS  PubMed  Google Scholar 

  19. Sandler RS, Nyren O, Ekbom A, Eisen GM, Yuen J, Josefsson S. The risk of esophageal cancer in patients with achalasia. A population-based study. JAMA 1995;274:1359–1362.

    Article  CAS  PubMed  Google Scholar 

  20. Streitz JM Jr, Ellis FH Jr, Gibb SP, Heatley GM. Achalasia and squamous cell carcinoma of the esophagus: analysis of 241 patients. Ann Thorac Surg 1995;59:1604–1609.

    Article  PubMed  Google Scholar 

  21. Brucher BL, Stein HJ, Bartels H, Feussner H, Siewert JR. Achalasia and esophageal cancer: incidence, prevalence, and prognosis. World J Surg 2001;25:745–749.

    Article  CAS  PubMed  Google Scholar 

  22. Aggestrup S, Holm JC, Sorensen HR. Does achalasia predispose to cancer of the esophagus? Chest 1992;102:1013–1016.

    Article  CAS  PubMed  Google Scholar 

  23. Zendehdel K, Nyren O, Edberg A, Ye W. Risk of oesophageal adenocarcinoma in achalasia patients, a retrospective cohort study in Sweden. Am J Gastroenterol 2007;102:1–5.

    Article  Google Scholar 

  24. Richards WO, Torquati A, Holzman MD, et al. Heller myotomy versus Heller myotomy with Dor fundoplication for Achalasia: a prospective randomized double-blind clinical trial. Ann Surg 2004;240:405–415.

    Article  PubMed  Google Scholar 

  25. Rice TW, McKelvey AA, Richter JE, et al. A physiologic clinical study of achalasia: should Dor fundoplication be added to Heller myotomy? J Thorac Cardiovasc Surg 2005;130:1593–1600.

    Article  PubMed  Google Scholar 

  26. Campos GM, Vittinghoff E, Rabl C, Takata M, Gadenstatter M, Lin F, Ciovica R. Endoscopic and Surgical Treatments for Achalasia A Systematic Review and Meta-Analysis. Ann Surg 2009;249(1):45–57

    Google Scholar 

  27. Topart P, Deschamps C, Taillefer R, Duranceau A. Long-term effect of total fundoplication on the myotomized esophagus. Ann Thorac Surg 1992;54:1046–1052.

    CAS  PubMed  Article  Google Scholar 

  28. Grotenhuis BA, Wijnhoven BPL, Jamieson GG, Devitt PG, Bessell JR, Watson DI. Defining a learning curve for laparoscopic cardiomyotomy. World J Surg 2008:32;1689–1694.

    Article  PubMed  Google Scholar 

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Acknowledgments

The authors are grateful for the contributions of surgeons from the Royal Adelaide Hospital who contributed patients to the database. We are also acknowledge the assistance of Ms. Lorelle Smith, Ms. Nicky Ascott, and Ms. Carolyn Lally who coordinated collection and entry of clinical outcome data into the database.

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Correspondence to David Ian Watson.

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Chen, Z., Bessell, J.R., Chew, A. et al. Laparoscopic Cardiomyotomy for Achalasia: Clinical Outcomes Beyond 5 Years. J Gastrointest Surg 14, 594–600 (2010). https://doi.org/10.1007/s11605-010-1158-2

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  • DOI: https://doi.org/10.1007/s11605-010-1158-2

Keywords

  • Achalasia
  • Laparoscopy
  • Cardiomyotomy
  • Long-term follow-up
  • Esophagus
  • Dysphagia