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Fast-track Surgery Improves Postoperative Recovery in Patients with Gastric Cancer: A Randomized Comparison with Conventional Postoperative Care

Journal of Gastrointestinal Surgery volume 14, pages 620–627 (2010)Cite this article

Abstract

Background

Fast-track surgery is a new, promising comprehensive program for surgical patients and is beneficial to recovery. Prospective randomized, controlled clinical trials involving fast-track surgery for gastric cancer are lacking.

Patient and methods

Ninety-two patients with gastric cancer were randomly divided into a fast-track surgery group (n = 45) and conventional surgery group (n = 47). We compared outcomes (duration of postoperative stay in hospital, fever, and flatus, complications, and medical costs); postoperative serum levels of tumor necrosis factor-α, interleukin-6, and C-reactive protein; and resting energy expenditure between two groups.

Results

Compared with the conventional surgery group, the fast-track surgery group had no more complications (P > 0.05) with a significantly shorter duration of fever, flatus, and hospital stay, and less medical costs as well as a higher quality of life score on hospital discharge (all P < 0.05). With a significantly lower resting energy expenditure (days 1 and 3) postoperatively (P < 0.05), the fast-track surgery group showed a lower serum level of tumor necrosis factor-α (days 1 and 3), interleukin-6 (days 1 and 3), and C-reactive protein (days 1, 3, and 7) than the conventional surgery group (all P < 0.05).

Conclusions

Fast-track surgery can lessen postoperative stress reactions and accelerate rehabilitation for patients with gastric cancer.

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Figure 1
Figure 2

Abbreviations

CRP:

C reaction protein

FTS:

fast-track surgery

GC:

Gastric cancer

IL-6:

interleukin-6

REE:

resting energy expenditure

TNF-α:

tumor necrosis factor-α

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Affiliations

  1. Department of General Surgery, Affiliated Hospital of Qingdao University Medical College, Jiangsu Road 16#, Qingdao, 266003, People’s Republic of China

    Dongsheng Wang, Ying Kong, Bei Zhong, Xiaobin Zhou & Yanbing Zhou

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  1. Dongsheng Wang
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  2. Ying Kong
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  3. Bei Zhong
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  4. Xiaobin Zhou
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  5. Yanbing Zhou
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Correspondence to Yanbing Zhou.

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Wang, D., Kong, Y., Zhong, B. et al. Fast-track Surgery Improves Postoperative Recovery in Patients with Gastric Cancer: A Randomized Comparison with Conventional Postoperative Care. J Gastrointest Surg 14, 620–627 (2010). https://doi.org/10.1007/s11605-009-1139-5

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  • DOI: https://doi.org/10.1007/s11605-009-1139-5

Keywords

  • Fast-track surgery
  • Gastric cancer
  • Stress reaction
  • Conventional surgery