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A Matched Case-Control Study of Preoperative Biliary Drainage in Patients with Pancreatic Adenocarcinoma: Routine Drainage Is Not Justified

  • 2009 SSAT Poster Presentation
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Background

Preoperative biliary drainage (PBD) prior to pancreaticoduodenectomy (PD) continues to be routine in many centers despite retrospective and randomized data showing that PBD increases perioperative infectious complications.

Methods

Review of a prospectively maintained database identified 340 consecutive patients with pancreatic adenocarcinoma who underwent PD between 2000 and 2005. From this cohort, 94 PBD and 94 nonstented (no-PBD) patients were matched for age, gender, preoperative albumin, and bilirubin levels (PBD group: prestent bilirubin; no-PBD group: preoperative bilirubin).

Results

The majority of PBD patients (89%) underwent internal endoscopic biliary drainage. Stent-related complications occurred in 46 patients (23%) and resulted in a significant delay in time to resection. In the matched-pair comparison, there was more operative blood loss in PBD patients, but similar operative times, transfusions, and hospital stay. Bile cultures were positive in 82% of PBD patients versus 7% no PBD. There was a statistically significant increase in infectious complications including wound infections and intra-abdominal abscess in PBD patients, but equal incidence of anastomotic leak.

Conclusions

In this case-matched control study, PBD was associated with a stent-related complication rate of 23% and resulted in a twofold increase in postpancreatectomy infectious complications. The routine use of PBD remains unjustified.

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Authors and Affiliations

  1. Department of Surgery, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY, 10065, USA

    James J. Mezhir, Murray F. Brennan, Michael I. D’Angelica, Yuman Fong, Ronald P. DeMatteo, William R. Jarnagin & Peter J. Allen

  2. Department of Epidemiology and Biostatistics, Memorial-Sloan Kettering Cancer Center, New York, NY, USA

    Raymond E. Baser

Authors
  1. James J. Mezhir
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  2. Murray F. Brennan
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  3. Raymond E. Baser
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  4. Michael I. D’Angelica
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  5. Yuman Fong
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  6. Ronald P. DeMatteo
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  7. William R. Jarnagin
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  8. Peter J. Allen
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Corresponding author

Correspondence to Peter J. Allen.

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Mezhir, J.J., Brennan, M.F., Baser, R.E. et al. A Matched Case-Control Study of Preoperative Biliary Drainage in Patients with Pancreatic Adenocarcinoma: Routine Drainage Is Not Justified. J Gastrointest Surg 13, 2163–2169 (2009). https://doi.org/10.1007/s11605-009-1046-9

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  • DOI: https://doi.org/10.1007/s11605-009-1046-9

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