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A Central Pancreatectomy for Benign or Low-Grade Malignant Neoplasms

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Inctroduction

A central pancreatectomy is a parenchyma-sparing procedure that is performed to reduce long-term endocrine and exocrine insufficiency.

Method

In this study, we analyzed the perioperative course, the frequency of postoperative onset of diabetes mellitus, and long-term change of body weight in patients undergoing a central pancreatectomy, in comparison to the patients undergoing a distal pancreatectomy for low-grade neoplasms including cystic neoplasms and neuroendocrine tumors.

Results and Discussion

The rate of postoperative complications including grade B/C pancreatic fistula was no different between both groups. Only one patient undergoing a central pancreatectomy (4.7%) developed new onset of mild diabetes, whereas 35% in the distal pancreatectomy group developed new onset or worsening diabetes (p = 0.0129). The body weight in the distal pancreatectomy group was significant lower than that in the central pancreatectomy group at 1 and 2 years after surgery (1 year; P < 0.0001, 2 years; P = 0.0055), and the body weight in the patients undergoing a central pancreatectomy improved to preoperative values within 2 years after surgery.

Conclusion

A central pancreatectomy is a safe procedure for the treatment of low-grade malignant neoplasms in the pancreatic body; the rate of onset of diabetes is minimal, and the body weight improves early in the postoperative course.

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Authors and Affiliations

  1. Second Department of Surgery, Wakayama Medical University, School of Medicine, 811-1 Kimiidera, Wakayama, 641-8510, Japan

    Seiko Hirono, Masaji Tani, Manabu Kawai, Shinomi Ina, Ryohei Nishioka, Motoki Miyazawa, Atsushi Shimizu, Kazuhisa Uchiyama & Hiroki Yamaue

Authors
  1. Seiko Hirono
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  2. Masaji Tani
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  3. Manabu Kawai
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  4. Shinomi Ina
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  5. Ryohei Nishioka
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  6. Motoki Miyazawa
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  7. Atsushi Shimizu
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  8. Kazuhisa Uchiyama
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  9. Hiroki Yamaue
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Corresponding author

Correspondence to Hiroki Yamaue.

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Hirono, S., Tani, M., Kawai, M. et al. A Central Pancreatectomy for Benign or Low-Grade Malignant Neoplasms. J Gastrointest Surg 13, 1659–1665 (2009). https://doi.org/10.1007/s11605-009-0934-3

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  • DOI: https://doi.org/10.1007/s11605-009-0934-3

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