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Does Low Molecular Weight Heparin Impair Anastomotic Wound Healing?

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Journal of Gastrointestinal Surgery

Abstract

Background

Enoxaparin is an important molecule which had been using in prophylaxis and treatment of deep venous thrombosis. Also, it is showed that it prevents postsurgical peritoneal adhesions in rats. It is aimed to evaluate its effects on gastrointestinal wound healing.

Methods

Thirty Wistar albino rats were divided into three groups as control, subcutan, and intraperitoneal enoxaparin groups. Left colon anastomoses were performed. On postoperative seventh day, anastomotic healing was evaluated by measuring anastomotic bursting pressure, tissue hydroxyproline levels, and histopathological examination.

Results

The anastomotic bursting pressure was highest in subcutan enoxaparin group (p < 0.001), intraperitoneal enoxaparin group (p < 0.01) came the second, and the control group has the worst value. The hydroxyproline results were found nearly similar to the bursting pressure values (subcutan (p < 0.001) > intraperitoneal (p < 0.05) > control). Neovascularization in subcutan group (p < 0.001) has a statistically significant difference to other groups.

Conclusion

Enoxaparin did not interfere with colonic anastomotic resistance but improved the intestinal wound healing.

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Authors and Affiliations

  1. General Surgery Department, Ankara Ataturk Teaching and Research Hospital, Askaabat Cad. Eser Sitesi B Blok 3.Giris, Daire:11 Bahcelievler, 06490, Ankara, Turkey

    Emre Ergul, Yigit Mehmet Ozgun, Gulten Kiyak, Birol Korukluoglu & Ahmet Kusdemir

  2. Pathology Department, Gazi University, School of Medicine, Ankara, Turkey

    Gonca Barit Ozgun

Authors
  1. Emre Ergul
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  2. Yigit Mehmet Ozgun
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  3. Gulten Kiyak
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  4. Gonca Barit Ozgun
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  5. Birol Korukluoglu
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  6. Ahmet Kusdemir
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Correspondence to Emre Ergul.

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Ergul, E., Ozgun, Y.M., Kiyak, G. et al. Does Low Molecular Weight Heparin Impair Anastomotic Wound Healing?. J Gastrointest Surg 13, 798–803 (2009). https://doi.org/10.1007/s11605-008-0771-9

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  • DOI: https://doi.org/10.1007/s11605-008-0771-9

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