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Superior Mesenteric Artery Syndrome: Diagnosis and Treatment Strategies



Superior mesenteric artery (SMA) syndrome is an unusual cause of vomiting and weight loss resulting from the compression of the third part of the duodenum by the SMA. Various medical and psychiatric conditions may result in the initial rapid weight loss which causes narrowing of the aortomesenteric angle. The vomiting and obstructive syndrome is then self-perpetuated regardless of the initiating factors. The young age and nonspecific symptoms often lead to a delay in diagnosis.


A series of eight cases is presented reviewing the presentation, investigations, surgical treatment by division of duodenum and duodenojejunostomy, and outcomes.


SMA syndrome is a well-described entity which must be considered as a cause of vomiting associated with significant weight loss in young adults. Surgical treatment should be allied with psychological assessment to treat any underlying psychosocial abnormality.

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Correspondence to N. D. Merrett.

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Merrett, N.D., Wilson, R.B., Cosman, P. et al. Superior Mesenteric Artery Syndrome: Diagnosis and Treatment Strategies. J Gastrointest Surg 13, 287–292 (2009).

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  • Superior mesenteric artery syndrome
  • Cast syndrome
  • Wilkie’s syndrome
  • Duodenal obstruction
  • Strong’s procedure
  • Laparoscopy
  • Duodenojejunal bypass