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Atopy is a Risk Factor for Acute Appendicitis? A Prospective Clinical Study

  • Published:
Journal of Gastrointestinal Surgery

Abstract

Purpose

The purpose of the study was to assess the role of atopy on the development of appendicitis. Acute appendicitis is the most common indication for emergent laparotomy especially in the late teens and early 20s. The pathogenesis generally begins with luminal obstruction caused by fecal mass, seeds, stricture, and bacterial, parasitic, or viral infections. The present study was designed to evaluate whether allergic reaction is indeed an undefined leading factor for luminal obstruction.

Material and Methods

Mix inhalant and food prick tests were performed in 111 patients who underwent appendectomy for acute appendicitis and in 100 control patients. The material of appendectomy was examined, acute appendicitis was verified and graded according to the severity of inflammation and eosinophilic infiltration rate in the wall of appendix by a pathologist. Demographic data were recorded, and peripheral eosinophil count was also performed.

Results

Mix prick test of 33 patients (29.7%) and food prick test of 14 patients (12.6%) were positive in study group when compared with 7 patients (7%) and 1 patient (1%) in control group (p < 0.001). A total of 38 patients (34.2%) in the study group were reactive with mix or food prick test when compared with 8 patients (8%) in control group. There was no significant difference between eosinophilic infiltration rate, peripheral eosinophil count, severity of inflammation, and Alvarado score of mix prick test positive and negative patients in study group.

Conclusion

Atopy incidence in patients with acute appendicitis was significantly higher when compared with control group. However, eosinophilic infiltration rate, inflammation grade, and peripheral eosinophil count were not able to explain the relationship between the two conditions. Atopy is a risk factor for acute appendicitis.

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Authors and Affiliations

  1. Department of General Surgery, Gulhane Military Medical Academy (GATA), 06018 Etlik, Ankara, Turkey

    Ali Harlak, Oner Mentes & Zafer Kilbas

  2. Department of Allergy, Gulhane Military Medical Academy (GATA), Ankara, Turkey

    Mustafa Gulec, Zafer Caliskaner & Fuat Erel

  3. Department of Pathology, Gulhane Military Medical Academy (GATA), Ankara, Turkey

    Onder Onguru

  4. Department of Public Health, Gulhane Military Medical Academy (GATA), Ankara, Turkey

    Cengizhan Acikel

Authors
  1. Ali Harlak
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  2. Mustafa Gulec
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  3. Oner Mentes
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  4. Zafer Kilbas
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  5. Onder Onguru
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  6. Cengizhan Acikel
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  7. Zafer Caliskaner
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  8. Fuat Erel
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Correspondence to Ali Harlak.

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Harlak, A., Gulec, M., Mentes, O. et al. Atopy is a Risk Factor for Acute Appendicitis? A Prospective Clinical Study. J Gastrointest Surg 12, 1251–1256 (2008). https://doi.org/10.1007/s11605-008-0511-1

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  • DOI: https://doi.org/10.1007/s11605-008-0511-1

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