Skip to main content
Log in

Malignant Peripheral Nerve Sheath Tumor: An Unusual Cause of Intussusception

  • gi image
  • Published:
Journal of Gastrointestinal Surgery


Malignant peripheral nerve sheath tumors (MPNST) are defined as any tumor arising from a peripheral nerve or showing nerve sheath differentiation. The majority of these tumors arise on the trunk, extremities, or head and neck region. The literature to date has fewer than 14 cases of MPNST arising in the gastrointestinal tract, and only two cases were ever reported in the small intestine, one of which was a recurrent disease. In this paper, we report the first US case of an MPNST arising in the small intestine and presenting as intussusception.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Figure 1
Figure 2

Similar content being viewed by others


  1. Nozu T, Takahashi A, Asakawa H, et al. Malignant intestinal schwannoma: a case review and a review of the literature in Japan. Intern Med. 1995;34:1101–1105.

    Article  PubMed  CAS  Google Scholar 

  2. Yilmaz F, Uzunlar AK, Bukte Y. Recurrent malignant schwannoma of the small b. Acta Med Austriaca. 2004;31:58–60.

    PubMed  Google Scholar 

  3. Doorn PF, Molenaar WM, Buter J, et al. Malignant peripheral nerve sheath tumors in patients with or without neurofibromatosis. Eur J Surg Onc. 1995;21:78–82.

    Article  CAS  Google Scholar 

  4. Perrin RG, Guha A. Malignant peripheral nerve sheath tumors. Neurosurg Clin N Am. 2004;15:203–216.

    Article  PubMed  Google Scholar 

  5. Talamonti M, Goetz L, et al. Primary cancers of the small bowel. Arch Surgery. 2002;137:564–571.

    Article  Google Scholar 

  6. Enzinger FM, Weiss SW. Malignant Tumors of Peripheral Nerves, 3rd edition. St. Louis (MO): Mosby; 1995.

    Google Scholar 

  7. Weiss SW, Langloss JM, Enzinger FM. Value of S-100 protein in the diagnosis of soft tissue tumors with particular reference to benign and malignant Schwann cell tumors. Lab Invest. 1983;49:299–308.

    PubMed  CAS  Google Scholar 

  8. Kindblom LG, Ahlden M, Meis-Kindblom JM, et al. Immunohistochemical analysis of P53, MDM2, proliferating cell nuclear antigen and Ki67 in benign and malignant peripheral nerve sheath tumours. Virchows Arch. 1995;427:19–26.

    Article  PubMed  CAS  Google Scholar 

  9. Anghileri M, Miceli R, Fiore M, et al. Malignant peripheral nerve sheath tumors prognostic factors and survival in a series of patients treated at a single Institution. Cancer. 2006;107:1065–1074.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Dana A. Telem.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Telem, D.A., Pertsemlidis, D. Malignant Peripheral Nerve Sheath Tumor: An Unusual Cause of Intussusception. J Gastrointest Surg 12, 1609–1611 (2008).

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: