Journal of Gastrointestinal Surgery

, Volume 11, Issue 9, pp 1168–1174 | Cite as

Vascular Resection and Reconstruction for Pancreatic Malignancy: A Single Center Survival Study

  • Mohammad Al-Haddad
  • J. Kirk Martin
  • Justin Nguyen
  • Surakit Pungpapong
  • Massimo Raimondo
  • Timothy Woodward
  • George Kim
  • Kyung Noh
  • Michael B. Wallace
Article

Abstract

Introduction

Pancreatic cancer is one of the leading causes of cancer-related death in the USA. Recently, several centers have introduced portal and superior mesenteric vein resection and reconstruction during extended pancreatectomy, rendering the previously inoperable cases resectable.

Aim

The aim of this study is to confirm whether patients with locally advanced pancreatic cancer and mesenteric vascular invasion can be cured with extended pancreatectomy with vascular reconstruction (VR) and to compare their survival to patients treated with pancreatectomy without VR and those treated without resection (palliation).

Methods

Survival of 22 patients who underwent pancreatectomy with VR was compared with two control groups: 54 patients who underwent pancreatectomy without the need for VR and 28 patients whose pre-operative imaging suggested resectability but whose laparotomy indicated inoperability.

Results

A slight survival benefit was noted in patients who did not require VR (33.5%) compared to those who did require VR [20%, p = 0.18], although not reaching statistical significance. Despite a low 15% three-year survival in patients treated palliatively, this was not statistically different compared to survival after resection with VR (P = 0.23). The presence of nodal metastasis was associated with worse survival (p = 0.006), and the use of adjuvant therapy was associated with better survival (p = 0.001).

Conclusion

Pancreatic cancers that require VR to completely resect the tumor have a similar survival to those not requiring VR. Long-term survival was achievable in approximately 1 out 5 patients requiring VR, although we were not able to demonstrate statistically improved survival compared to palliative care.

Keywords

Pancreatic cancer Vascular reconstruction Post operative survival 

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Copyright information

© The Society for Surgery of the Alimentary Tract 2007

Authors and Affiliations

  • Mohammad Al-Haddad
    • 1
  • J. Kirk Martin
    • 2
  • Justin Nguyen
    • 3
  • Surakit Pungpapong
    • 1
  • Massimo Raimondo
    • 1
  • Timothy Woodward
    • 1
  • George Kim
    • 4
  • Kyung Noh
    • 1
  • Michael B. Wallace
    • 1
    • 5
  1. 1.Division of Gastroenterology and HepatologyMayo Clinic College of MedicineJacksonvilleUSA
  2. 2.Division of General SurgeryMayo Clinic College of MedicineJacksonvilleUSA
  3. 3.Division of Transplant SurgeryMayo Clinic College of MedicineJacksonvilleUSA
  4. 4.Division of Hematology and OncologyMayo Clinic College of MedicineJacksonvilleUSA
  5. 5.Division of Gastroenterology and HepatologyMayo Clinic JacksonvilleJacksonvilleUSA

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