Skip to main content
Log in

Bile duct adenoma: imaging features and radiologic–pathologic correlation

  • Original Article
  • Published:
Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

This study aimed to reveal characteristic imaging features of bile duct adenoma (BDA) by radiologic–pathologic correlation.

Materials and methods

We retrospectively analyzed pathological and imaging findings of seven patients with BDA.

Results

The median maximum diameter of BDA was 5.5 mm. Six lesions had hemispheric morphology. Seven lesions were located in the liver subcapsular region, and proliferation of bile ductules without atypia and fibrous stroma was observed. Two lesions had different microscopic findings. In both lesions, proliferation of bile ductules without atypia was observed in the margin. In one lesion, the percentage of fibrosis and hyalinization was higher at the center than at the margin. In the other lesion, inflammatory cell infiltration was observed in the center. On contrast-enhanced imaging, BDAs showed hypervascularity in the early phase and prolonged enhancement in the delayed phase. On contrast-enhanced multidetector computed tomography during hepatic arteriography, two lesions showed ring-like enhancement in the first phase and prolonged enhancement in the second phase. These were the different histopathologic features of BDAs between the margin and center.

Conclusion

Bile duct adenoma can be characterized as a small semicircular lesion located in the liver subcapsular region, which show hypervascularity in the early phase with prolonged enhancement.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Allaire GS, Rabin L, Ishak KG, Sesterhenn IS. Bile duct adenoma. A study of 152 cases. Am J Surg Pathol. 1988;12:708–15.

    Article  CAS  Google Scholar 

  2. Aishima S, Tanaka Y, Kubo Y, Shirabe K, Maehara Y, Oda Y. Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: pathogenesis and historical characteristics. Pathol Int. 2014;64:551–9.

    Article  CAS  Google Scholar 

  3. Pujals A, Amaddeo G, Castain C, Bioulac-Sage P, Compagnon P, Zucmann-Rossi J, et al. Author information BRAF V600E mutations in bile duct adenomas. Hepatology. 2015;61:403–5.

    Article  CAS  Google Scholar 

  4. Hasebe T, Sakamoto M, Mukai K, Kawano N, Konishi M, Ryu M, et al. Cholangiocarcinoma arising in bile duct adenoma with focal area of bile duct hamartoma. Virchows Arch. 1995;426:209–13.

    Article  CAS  Google Scholar 

  5. Pinho AC, Melo RB, Oliveira M, Almeida M, Lopes J, Graca L, et al. Adenoma-carcinoma sequence in intrahepatic cholangiocarcinoma. Int J Surg Case Rep. 2012;3:131–3.

    Article  Google Scholar 

  6. Watanabe M, Shiozawa K, Ikehara T, Ichimori M, Shinohara M, Kikuchi Y, et al. Ultrasonography of intrahepatic bile duct adenoma with renal cell carcinoma: correlation with pathology. J Med Ultrason. 2013;40:251–6.

    Article  Google Scholar 

  7. Takumi K, Fukukura Y, Nagasato K, Nakajo M, Natsugoe S, Higashi M. Intrahepatic bile duct adenoma mimicking hepatic metastasis: case report and review of the literature. Magn Reson Med Sci. 2013;12:141–5.

    Article  Google Scholar 

  8. An C, Park S, Choi YJ. Diffusion-weighted MRI in intra hepatic bile duct adenoma arising from the cirrhotic liver. Korean J Radiol. 2013;14:769–75.

    Article  Google Scholar 

  9. Tajima T, Honda H, Kuroiwa T, Yoshimitsu K, Irie H, Aibe T, et al. Radiologic features of intrahepatic bile duct adenoma: a look at the surface of the liver. J Comput Assist Tomogr. 1999;23:690–5.

    Article  CAS  Google Scholar 

  10. Chuy JA, Garg I, Graham RP, VanBuren WM, Venkatesh SK. Imaging features of bile duct adenoma: case series and review of literature. Diagn Interv Radiol. 2018;24(5):249–54.

    Article  Google Scholar 

  11. Song KD, Jeong WK. Benign nodules mimicking hepatocellular carcinoma on gadoxetic acid-enhanced liver MRI. Clin Mol Hepatol. 2015;21:187–91.

    Article  Google Scholar 

  12. Maeda E, Uozumi K, Kato N, Akahane M, Inoh S, Inoue Y, Beck Y, et al. Magnetic resonance findings of bile duct adenoma with calcification. Radiat Med. 2006;24:459–62.

    Article  Google Scholar 

  13. Ahn JM, Paik YH, Lee JH, Cho JY, Sohn W, Gwak GY, et al. Intrahepatic bile duct adenoma in a patient with chronic hepatitis B accompanied by elevation of alpha-fetoprotein. Clin Mol Hepatol. 2015;21:393–7.

    Article  Google Scholar 

  14. Chen L, Xu MY, Chen F. Bile duct adenoma: a case report and literature review. World J Surg Oncol. 2014;26(12):125.

    Article  Google Scholar 

  15. Wei J, Zhang D, Yang J, Xu C. Intrahepatic bile duct adenoma (peribiliary grand hemartoma): a case report and review of literature. Int J Clin Exp Pathol. 2015;8:5908–13.

    PubMed  PubMed Central  Google Scholar 

  16. Sica GT, Ji H, Ros PR. Computed tomography and magnetic resonance imaging of hepatic metastases. AJR Am J Roentgenol. 2000;174(3):691–8.

    Article  CAS  Google Scholar 

  17. Valls C, Gumà A, Puig I, Sanchez A, Andía E, Serrano T, et al. Intrahepatic peripheral cholangiocarcinoma: CT evaluation. Abdom Imaging. 2000;25(5):490–6.

    Article  CAS  Google Scholar 

  18. Fukukura Y, Hamanoue M, Fujiyoshi F, Sasaki M, Haruta K, Inoue H, et al. Cholangiolocellular carcinoma of the liver: CT and MR findings. J Comput Assist Tomogr. 2000;24(5):809–12.

    Article  CAS  Google Scholar 

  19. Kim SH, Lee WJ, Lim HK, Park CK. Sclerosing hepatic carcinoma: helical CT features. Abdom Imaging. 2007;32(6):725–9.

    Article  Google Scholar 

  20. Yoshikawa J, Matsui O, Kadoya M, Gabata T, Arai K, Takashima A. Dalayed enhancement of fibrotic areas in hepatic masses: CT-pathologic correlation. J Comput Assist Tomogr. 1992;16(2):206–11.

    Article  CAS  Google Scholar 

Download references

Funding

This study has not been funded by any company.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ryoji Tatsumi.

Ethics declarations

Conflict of interest

The authors indicate no conflicts of interest.

Ethical approval

This study has been approved by the research ethics committee of Sapporo Kosei General Hospital.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tatsumi, R., Ichihara, S., Suii, H. et al. Bile duct adenoma: imaging features and radiologic–pathologic correlation. Jpn J Radiol 38, 561–571 (2020). https://doi.org/10.1007/s11604-020-00938-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11604-020-00938-0

Keywords

Navigation