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Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database

Japanese Journal of Radiology volume 38, pages 85–92 (2020)Cite this article

Abstract

Purpose

Intraoperative radiotherapy (IORT) has emerged as an alternative to whole-breast external beam radiotherapy (EBRT) for early breast cancer. This study aimed to investigate the risk factors for survival after IORT or whole-breast EBRT in breast cancer patients.

Materials and methods

Breast cancer patients undergoing IORT or whole-breast EBRT were included from the surveillance, epidemiology, and end results database. Risk factors for overall survival (OS) and cancer-specific survival (CSS) were identified by Cox proportional hazards regression analysis.

Results

The IORT and EBRT groups did not differ significantly in OS and CSS. T2 stage (tumor size > 2 cm) was associated with poorer OS (aHR 3.49, 95% CI 1.05–11.62, P = 0.042), whereas ER-positive tumors were associated with better OS (aHR 0.26, 95% CI 0.09–0.76, P = 0.014).

Conclusion

IORT was not inferior than EBRT considering the OS and CSS in the short-term follow-up of early breast cancer. It may be a reasonable alternative to EBRT for early breast cancer in select patients with favorable tumor size and receptor status, given the need for long-term monitoring of local control and radiation toxicity.

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Funding

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Author information

Affiliations

  1. Department of Cardiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, 107 Yanjiang West Road, Guangzhou, 510120, Guangdong, People’s Republic of China

    Juan Lei

  2. Department of Mathematics, California State University Dominguez Hills, Carson, CA, USA

    Yi Wang

  3. Department of Radiation Oncology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China

    Zhuofei Bi

  4. Department of Ultrasound, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China

    Shengneng Xue

  5. Department of Endocrinology and Metabolism, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China

    Bing Ou

  6. Division of Cardiology, Heart and Vascular Center, University of Iowa Hospital and Clinics, Iowa, IA, USA

    Kan Liu

Authors
  1. Juan Lei
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  2. Yi Wang
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  3. Zhuofei Bi
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  4. Shengneng Xue
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  5. Bing Ou
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  6. Kan Liu
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Correspondence to Juan Lei.

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Cite this article

Lei, J., Wang, Y., Bi, Z. et al. Intraoperative radiotherapy (IORT) versus whole-breast external beam radiotherapy (EBRT) in early stage breast cancer: results from SEER database. Jpn J Radiol 38, 85–92 (2020). https://doi.org/10.1007/s11604-019-00891-7

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  • DOI: https://doi.org/10.1007/s11604-019-00891-7

Keywords

  • Early stage breast cancer
  • Intraoperative radiotherapy (IORT)
  • Whole-breast external beam radiotherapy
  • Prognosis
  • Survival