Changes in tissue gadolinium biodistribution measured in an animal model exposed to four chelating agents
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This study investigated the potential to reduce gadolinium levels in rodents after repetitive IV Gadodiamide administration using several chelating agents.
Materials and methods
The following six groups of rats were studied. Group 1: Control; Group 2: Gadodiamide only; Group 3: Meso-2,3-Dimercaptosuccinic acid (DMSA) + Gadodiamide; Group 4: N-Acetyl-l-cysteine (NAC) + Gadodiamide; Group 5: Coriandrum sativum extract + Gadodiamide; and Group 6: Deferoxamine + Gadodiamide. Brain, kidney, and blood samples were evaluated via inductively coupled plasma mass spectrometry. The brain was also evaluated histologically.
Kidney gadolinium levels in Groups 4 and 5 were approximately double that of Group 2 (p = 0.033 for each). There was almost no calcification in rat hippocampus for Group 4 rodents when compared with Groups 2, 3, 5 and 6.
Our preliminary study shows that excretion to the kidney has a higher propensity in NAC and Coriandrum sativum groups. It may be possible to change the distribution of gadolinium by administrating several agents. NAC may lower Gadodiamide-induced mineralization in rat hippocampus.
KeywordsGadolinium deposition Dimercaptosuccinic acid N-Acetyl-l-cysteine Coriandrum sativum Deferoxamine
This study is dedicated to pharmacist Ozler Kiris who provided inspiration for this preclinical study passed away unexpectedly during preparation phase of this work. Additionally, our special appreciation extends to Elif Tetik Acar who continuously assisted us during manipulation of lateral tail vein of rodents.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
Animal Experiment Ethics Committee of Ege University (ID: 2017-007).
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