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Liver assessment using Gd-EOB-DTPA-enhanced magnetic resonance imaging in primary biliary cholangitis patients

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the feasibility of utilizing gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA)-enhanced magnetic resonance imaging (MRI) for the assessment of Child–Pugh class and for differentiating between patients with primary biliary cholangitis (PBC) and posthepatitic cirrhosis.

Materials and methods

45 PBC patients and 45 posthepatitic cirrhosis patients were enrolled and Gd-EOB-DTPA-enhanced MRI was applied. The average relative signal enhancement (RE) of the liver and average contrast to noise ratio (CNR) of common bile duct at 4, 20, and 50 min between different Child–Pugh classes of PBC patients were compared. The RE and CNR in all timepoints in patients with the same Child–Pugh class were compared between PBC patients and posthepatitic cirrhosis patients.

Results

The RE of liver and CNR of common bile duct at 4, 20, and 50 min was significantly different between all Child–Pugh classes of PBC patients. There were also no significant differences in the RE of liver and CNR of common bile duct in all timepoints between patients with PBC and posthepatitic cirrhosis in the same Child–Pugh class.

Conclusion

Gd-EOB-DTPA-enhanced MRI is feasible for liver function assessment in PBC patients. However, the ability of this modality in differentiating liver cirrhosis of different etiologies requires further investigation.

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Acknowledgements

We thank Yi Zhang, Ligang Deng, Wei Guan, and Guilian Jiang for their technical assistance in performing the MRI images. The authors also appreciate the help of the teachers who work in the Medical records room, because they provide us with great convenience in looking up patients’ clinical data.

Funding

This study was approved by the Health Industry Special Scientific Research Project (No. 201402019).

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Authors and Affiliations

  1. Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Xicheng District, Beijing, 100050, China

    Dan Han, Erhu Jin & Wen He

  2. Department of Radiology, Beijing Anzhen Hospital, Capital Medical University, Chaoyang District, Beijing, 100029, China

    Jiayi Liu

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  1. Dan Han
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Correspondence to Dan Han.

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Ethical approval

This study was approved by the Ethics Committee of Beijing Friendship Hospital, Capital Medical University.

Ethical statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Han, D., Liu, J., Jin, E. et al. Liver assessment using Gd-EOB-DTPA-enhanced magnetic resonance imaging in primary biliary cholangitis patients. Jpn J Radiol 37, 412–419 (2019). https://doi.org/10.1007/s11604-019-00822-6

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  • DOI: https://doi.org/10.1007/s11604-019-00822-6

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