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Radiofrequency ablation versus cryoablation for T1b renal cell carcinoma: a multi-center study

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

To compare the clinical outcomes between radiofrequency ablation (RFA) and cryoablation for the treatment of clinical T1b (cT1b) renal cell carcinoma (RCC).

Materials and methods

The data of 46 patients [(39 men and 7 women, median age; 73 years, range 39–87 years)] were gathered from 3 institutions. RFA and cryoablation were performed on 23 patients each. The median number of ablation needle was 2 (range 1–4) and 4 (range 3–5, p < 0.0001) in RFA and cryoablation, respectively. Technique efficacy defined as coverage of the tumor by ablative zone, adverse events, local tumor progression, and survival were compared between the RFA and cryoablation groups.

Results

The primary technique efficacy rate was significantly higher in the cryoablation group (96%, 22/23) than in the RFA group (65%, 15/23, P = 0.02). There was no significant difference in the secondary technique efficacy rate after additional RFA and cryoablation [21/23 (91%) vs. 23/23 (100%); P = 0.24]. The incidence of grade 3 or higher adverse events was similar between the 2 groups (P > 0.99). There was no significant difference between local tumor progression rate after RFA and cryoablation [3/21 (14%) vs. 2/23 (9%); P = 0.66]. The 5-year overall survival rates were comparable between RFA and cryoablation (78 vs. 82%; P =0.82).

Conclusion

Other than primary technique efficacy, the clinical outcomes between RFA and cryoablation were similar in patients with cT1b RCC.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, Aichi Cancer Center Hospital, 1-1 Chikusa-ku Kanokoden, Nagoya, Aichi, 464-8681, Japan

    Takaaki Hasegawa, Yozo Sato & Yoshitaka Inaba

  2. Department of Radiology, Mie University School of Medicine, Mie, Japan

    Takashi Yamanaka

  3. Department of Radiology, Okayama University Medical School, Okayama, Japan

    Hideo Gobara

  4. Department of Interventional Radiology and Clinical Ultrasound Cente, Gunma University Hospital, Maebashi, Japan

    Masaya Miyazaki

  5. Department of Radiology, Hyogo College of Medicine, Nishinomiya, Japan

    Haruyuki Takaki & Koichiro Yamakado

Authors
  1. Takaaki Hasegawa
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  2. Takashi Yamanaka
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  3. Hideo Gobara
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  4. Masaya Miyazaki
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  5. Haruyuki Takaki
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  6. Yozo Sato
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  7. Yoshitaka Inaba
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  8. Koichiro Yamakado
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Corresponding author

Correspondence to Takaaki Hasegawa.

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Conflict of interest

The authors declare that they have no conflicts of interest.

Ethical statement

This retrospective study was approved by the institutional review board of each institution. Informed consent to perform RFA or cryoablation was obtained from all patients, but informed consent to be included in this study was waived because of the retrospective nature of this study.

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Hasegawa, T., Yamanaka, T., Gobara, H. et al. Radiofrequency ablation versus cryoablation for T1b renal cell carcinoma: a multi-center study. Jpn J Radiol 36, 551–558 (2018). https://doi.org/10.1007/s11604-018-0756-x

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  • DOI: https://doi.org/10.1007/s11604-018-0756-x

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