Japanese Journal of Radiology

, Volume 36, Issue 5, pp 340–344 | Cite as

Analysis of computed tomography density of liver before and after amiodarone administration

  • Masazumi Matsuda
  • Aoi Otaka
  • Tomoki Tozawa
  • Tomoyuki Asano
  • Koichi Ishiyama
  • Manabu Hashimoto
Original Article



To evaluate CT density of liver changes between before and after amiodarone administration.

Materials and methods

Twenty-five patients underwent non-enhanced CT including the liver before and after amiodarone administration. We set regions of interest (ROIs) at liver S8, spleen, paraspinal muscle, and calculated average CT density in these ROIs, then compared CT density between liver and other organs. Statistical differences between CT density of liver and various ratios before and after administration were determined, along with correlations between cumulative dose of amiodarone and liver density after administration, density change of liver, and various ratios after administration.


Liver density, liver-to-spleen ratio, and liver-to-paraspinal muscle ratio differed significantly between before and after amiodarone administration. No significant correlations were found between cumulative doses of amiodarone and any of liver density after administration, density change of liver, or various ratios after administration.


CT density of liver after amiodarone administration was significantly higher than that before administration. No correlations were identified between cumulative dose of amiodarone and either liver density after administration or density change of liver. Amiodarone usage should be checked when radiologists identify high density of the liver on CT.


Computed tomography Amiodarone CT density of liver 


Compliance with ethical standards

Conflict of interest

The authors have no conflicts of interest to declare.

Ethical statement

This study was approved by the clinical ethics committee of Akita University.


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Copyright information

© Japan Radiological Society 2018

Authors and Affiliations

  • Masazumi Matsuda
    • 1
  • Aoi Otaka
    • 1
  • Tomoki Tozawa
    • 1
  • Tomoyuki Asano
    • 1
  • Koichi Ishiyama
    • 1
  • Manabu Hashimoto
    • 1
  1. 1.Department of RadiologyAkita University Graduate School of MedicineAkitaJapan

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