Japanese Journal of Radiology

, Volume 36, Issue 4, pp 295–302 | Cite as

Evaluation of hemodynamic imaging findings of hypervascular hepatocellular carcinoma: comparison between dynamic contrast-enhanced magnetic resonance imaging using radial volumetric imaging breath-hold examination with k-space-weighted image contrast reconstruction and dynamic computed tomography during hepatic arteriography

  • Masahiro Kurozumi
  • Yasunari Fujinaga
  • Yoshihiro Kitou
  • Akira Yamada
  • Ayumi Ohya
  • Yasuo Adachi
  • Yoshinori Tsukahara
  • Marcel D. Nickel
  • Katsuya Maruyama
  • Takeshi Uehara
  • Shin-ichi Miyagawa
  • Masumi Kadoya
Original Article
  • 90 Downloads

Abstract

Purpose

To compare the visualization of hemodynamic imaging findings of hypervascular hepatocellular carcinoma (HCC) on dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) using radial volumetric imaging breath-hold examination with k-space-weighted image contrast reconstruction (r-VIBE-KWIC) versus dynamic computed tomography during hepatic arteriography (dyn-CTHA).

Materials and methods

We retrospectively reviewed the databases of preoperative DCE-MRI using r-VIBE-KWIC, dyn-CTHA, and postoperative pathology of resected specimens. Fourteen patients with 14 hypervascular HCCs underwent both DCE-MRI and dyn-CTHA. The imaging findings of the tumor and adjacent liver parenchyma were assessed on both modalities by two readers. The tumor enhancement time was also compared between the two modalities.

Results

On DCE-MRI/dyn-CTHA, early staining, peritumoral low-intensity or low-density bands, corona enhancement, and washout of HCC were observed in 14/14 (100%), 10/12 (83%), 11/14 (78%), and 4/14 (29%) patients, respectively. Pathologically, four HCCs with low-density bands on dyn-CTHA had no fibrous capsules. The median tumor enhancement time on DCE-MRI and dyn-CTHA was 24 (9–24) and 23 (8–35) s, respectively. The correlation coefficient between the two groups was 0.762 (P < 0.002).

Conclusions

DCE-MRI using r-VIBE-KWIC has diagnostic potential comparable with that of dyn-CTHA in the hemodynamic evaluation of hypervascular HCC except for the washout phenomenon.

Keywords

Dynamic contrast-enhanced magnetic resonance imaging Radial volumetric imaging breath-hold examination (VIBE) with k-space-weighted image contrast reconstruction Dynamic computed tomography during hepatic arteriography Hepatocellular carcinoma 

Abbreviations

HCC

Hepatocellular carcinoma

DCE-MRI

Dynamic contrast-enhanced magnetic resonance imaging

VIBE

Volumetric imaging breath-hold examination

KWIC

k-space-weighted image contrast reconstruction

dyn-CTHA

Dynamic computed tomography during hepatic arteriography

Notes

Acknowledgements

This work was supported partially by a “Grant-in-Aid for Scientific Research” (C) (15K09917) from the Ministry of Education, Culture, Sports, Science and Technology of Japan. We thank Angela Morben, DVM, ELS, from Edanz Group (www.edanzediting.com/ac) for editing a draft of this manuscript.

Compliance with ethical standards

Conflict of interest

The authors of this manuscript declare the relationships with the following companies: Dr. Marcel Dominik Nickel is an employer of Siemens Healthcare GmbH, and Mr. Katsuya Maruyama is an employer of Siemens Healthcare K. K. The authors thank these companies for allowing the use of the prototypical r-VIBE-KWIC for our study. The other authors declare that they have no conflict of interest.

Ethical approval

The study protocol was approved by the institutional review board of Shinshu University School of Medicine (no. 1981).

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Copyright information

© Japan Radiological Society 2018

Authors and Affiliations

  • Masahiro Kurozumi
    • 1
  • Yasunari Fujinaga
    • 1
  • Yoshihiro Kitou
    • 2
  • Akira Yamada
    • 1
  • Ayumi Ohya
    • 1
  • Yasuo Adachi
    • 2
  • Yoshinori Tsukahara
    • 1
  • Marcel D. Nickel
    • 3
  • Katsuya Maruyama
    • 4
  • Takeshi Uehara
    • 5
  • Shin-ichi Miyagawa
    • 6
  • Masumi Kadoya
    • 2
  1. 1.Department of RadiologyShinshu University School of MedicineMatsumotoJapan
  2. 2.Radiology Division of Shinshu University HospitalMatsumotoJapan
  3. 3.Siemens Healthcare GmbHErlangenGermany
  4. 4.DI Research and Collaboration DepartmentSiemens Healthcare K.K.TokyoJapan
  5. 5.Department of Laboratory MedicineShinshu University School of MedicineMatsumotoJapan
  6. 6.First Department of SurgeryShinshu University School of MedicineMatsumotoJapan

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