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Comparison of gadoxetic acid-enhanced dynamic MR imaging and contrast-enhanced computed tomography for preoperative evaluation of colorectal liver metastases

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the diagnostic efficacy of gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) vs. contrast-enhanced computed tomography (CE-CT) in the detection of liver metastasis in colorectal carcinoma patients.

Materials and methods

One-hundred fifty-eight consecutive patients with histopathologically confirmed colorectal carcinoma underwent EOB-MRI and CE-CT; 68 patients had 105 surgically confirmed liver metastases. Diagnostic analyses were performed according to sensitivity and positive predictive value (PPV) for liver metastasis detection in combined arterial- and hepatocyte-phase images vs. CE-CT by three readers blinded to clinical data. Diagnostic accuracy and sensitivity were evaluated using the alternative free-response receiver operating characteristic method.

Results

The overall sensitivity of EOB-MRI (91.4%) was significantly higher than that of CE-CT (80.9%, p < 0.001); the higher sensitivity of EOB-MRI was observed especially in smaller-sized lesions (73.3 vs. 56.0% for lesions ≤1 cm; 91.9 vs. 80.8% for lesions >1 cm and ≤2 cm; 99.2 vs. 95.7% for lesions >2 cm). EOB-MRI showed a significantly greater area under the receiver operating characteristic curve (Az value = 0.970) compared with CE-CT (Az value = 0.899, p < 0.01).

Conclusion

EOB-MRI provided higher detectability for liver metastases, especially for smaller-sized lesions, than CE-CT in patients with colorectal carcinoma.

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Authors and Affiliations

  1. Department of Radiology, Faculty of Medicine, Kindai University, 377-2 Ohnohigashi, Osakasayama, Osaka, 589-8511, Japan

    Nobuyuki Asato, Masakatsu Tsurusaki & Takamichi Murakami

  2. Division of Diagnostic Radiology, National Cancer Center, Tokyo, Japan

    Masakatsu Tsurusaki & Keitaro Sofue

  3. Department of Diagnostic Radiology, Graduate School of Medicine, Kobe University, Kobe, Japan

    Keitaro Sofue

  4. Department of Radiology, School of Medicine, Shimane University, Izumo, Japan

    Yoko Hieda & Takashi Katsube

  5. Department of Radiology, Faculty of Medicine, Hyogo Medical College, Nishinomiya, Japan

    Kazuhiro Kitajima

Authors
  1. Nobuyuki Asato
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  2. Masakatsu Tsurusaki
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  3. Keitaro Sofue
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  4. Yoko Hieda
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  5. Takashi Katsube
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  6. Kazuhiro Kitajima
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  7. Takamichi Murakami
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Correspondence to Masakatsu Tsurusaki.

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The authors declare that they have no conflict of interest.

Ethical statement

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual patients included in the study.

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Asato, N., Tsurusaki, M., Sofue, K. et al. Comparison of gadoxetic acid-enhanced dynamic MR imaging and contrast-enhanced computed tomography for preoperative evaluation of colorectal liver metastases. Jpn J Radiol 35, 197–205 (2017). https://doi.org/10.1007/s11604-017-0622-2

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  • DOI: https://doi.org/10.1007/s11604-017-0622-2

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