Skip to main content

Advertisement

SpringerLink
Log in

Radiofrequency ablation of pulmonary metastases from sarcoma: single-center retrospective evaluation of 46 patients

  • Original Article
  • Published:
Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

This retrospective, single-center study evaluated radiofrequency (RF) ablation for pulmonary metastases of sarcoma.

Materials and methods

Forty-six patients with sarcoma (144 pulmonary metastases) underwent 88 RF ablation sessions. Data regarding local tumor progression, efficacy, procedural adverse events (AEs; National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.0), overall survival (OS), and OS-associated prognostic factors were retrospectively evaluated using univariate analyses.

Results

Local progression occurred in 22 of 144 tumors (15.3%). Primary and secondary efficacy rates were 83.5 and 90.0% at 1 year and 76.3 and 81.4% at 2 years, respectively. Seventy-three grade 1 AEs, 33 grade 2 AEs, and no grade ≥ 3 AEs were observed. Twenty-eight patients (60.9%) remained alive and 18 died, yielding 1-, 2-, and 3-year OS rates of 80.6, 70.1, and 47.1% (median survival time, 31.7 months). Univariate analysis revealed extrapulmonary metastasis (P = 0.005), noncurative RF ablation (P = 0.009), and a post-RF ablation disease-free interval of ≤12 months (P = 0.015) as significant negative prognostic factors.

Conclusion

RF ablation is safe, offers good local control, and may be a viable treatment option for pulmonary metastasis of sarcoma.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Palussière J, Italiano A, Descat E, Ferron S, Cornélis F, Avril A, et al. Sarcoma lung metastases treated with percutaneous radiofrequency ablation: results from 29 patients. Ann Surg Oncol. 2011;18:3771–7.

    Article  PubMed  Google Scholar 

  2. Falk AT, Moureau-Zabotto L, Ouali M, Penel N, Italiano A, Bay JO, et al. Effect on survival of local ablative treatment of metastases from sarcomas: a study of the French Sarcoma Group. Clin Oncol (R Coll Radiol). 2015;27:48–55.

  3. Gadd MA, Casper ES, Woodruff JM, McCormack PM, Brennan MF. Development and treatment of pulmonary metastases in adult patients with extremity soft tissue sarcoma. Ann Surg. 1993;218:705–12.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. van Geel AN, Pastorino U, Jauch KW, Judson IR, van Coevorden F, Buesa JM, et al. Surgical treatment of lung metastases: the European Organization for Research and Treatment of Cancer—Soft Tissue and Bone Sarcoma Group study of 255 patients. Cancer. 1996;77:675–82.

  5. Snyder CL, Saltzman DA, Ferrell KL, Thompson RC, Leonard AS. A new approach to the resection of pulmonary osteosarcoma metastases: results of aggressive metastasectomy. Clin Orthop Relat Res. 1991;270:247–53.

    Google Scholar 

  6. Smith R, Pak Y, Kraybill W, Kane JM 3rd. Factors associated with actual long-term survival following soft tissue sarcoma pulmonary metastasectomy. Eur J Surg Oncol. 2009;35:356–61.

    Article  CAS  PubMed  Google Scholar 

  7. Treasure T, Fiorentino F, Scarci M, Møller H, Utley M. Pulmonary metastasectomy for sarcoma: a systematic review of reported outcomes in the context of Thames Cancer Registry data. BMJ Open. 2012;2:5. doi:10.1136/bmjopen-2012-001736.

    Google Scholar 

  8. Bielack SS, Kempf-Bielack B, Branscheid D, Carrle D, Friedel G, Helmke K, et al. Second and subsequent recurrences of osteosarcoma: presentation, treatment, and outcomes of 249 consecutive cooperative osteosarcoma study group patients. J Clin Oncol. 2009;27:557–65.

    Article  PubMed  Google Scholar 

  9. Matsui Y, Hiraki T, Gobara H, Iguchi T, Fujiwara H, Nagasaka T, et al. Long-term survival following percutaneous radiofrequency ablation of colorectal lung metastases. J Vasc Interv Radiol. 2015;26:303–10.

    Article  PubMed  Google Scholar 

  10. Matsui Y, Hiraki T, Gobara H, Fujiwara H, Iguchi T, Shirakawa Y, et al. Percutaneous radiofrequency ablation for pulmonary metastases from esophageal cancer: retrospective evaluation of 21 patients. J Vasc Interv Radiol. 2014;25:1566–72.

    Article  PubMed  Google Scholar 

  11. Hiraki T, Yamakado K, Ikeda O, Matsuoka T, Kaminou T, Yamagami T, et al. Percutaneous radiofrequency ablation for pulmonary metastases from hepatocellular carcinoma: results of a multicenter study in Japan. J Vasc Interv Radiol. 2011;22:741–8.

    Article  PubMed  Google Scholar 

  12. Soga N, Yamakado K, Gohara H, Takaki H, Hiraki T, Yamada T, et al. Percutaneous radiofrequency ablation for unresectable pulmonary metastases from renal cell carcinoma. BJU Int. 2009;104:790–4.

    Article  PubMed  Google Scholar 

  13. Hiraki T, Gobara H, Mimura H, Sano Y, Tsuda T, Iguchi T, et al. Does tumor type affect local control by radiofrequency ablation in the lungs? Eur J Radiol. 2010;74:136–41.

    Article  PubMed  Google Scholar 

  14. de Baère T, Aupérin A, Deschamps F, Chevallier P, Gaubert Y, Boige V, et al. Radiofrequency ablation is a valid treatment option for lung metastases: experience in 566 patients with 1037 metastases. Ann Oncol. 2015;26:987–91.

    Article  PubMed  PubMed Central  Google Scholar 

  15. Ihara H, Gobara H, Hiraki T, Mitsuhashi T, Iguchi T, Fujiwara H, et al. Radiofrequency ablation of lung tumors using a multitined expandable electrode: impact of the electrode array diameter on local tumor progression. J Vasc Interv Radiol. 2016;27:87–95.

    Article  PubMed  Google Scholar 

  16. Hiraki T, Gobara H, Mimura H, Toyooka S, Fujiwara H, Yasui K, et al. Radiofrequency ablation of lung cancer at Okayama University Hospital: a review of 10 years of experience. Acta Med Okayama. 2011;65:287–97.

  17. Ahmed M, Solbiati L, Brace CL, Breen DJ, Callstrom MR, Charboneau JW, et al. Image-guided tumor ablation: standardization of terminology and reporting criteria—a 10-year update. J Vasc Interv Radiol. 2014;25:1691–705.

  18. Tascilar M, Loos WJ, Seynaeve C, Verweij J, Sleijfer S. The pharmacologic basis of ifosfamide use in adult patients with advanced soft tissue sarcomas. Oncologist. 2007;12:1351–60.

    Article  CAS  PubMed  Google Scholar 

  19. Weiser MR, Downey RJ, Leung DH, Brennan MF. Repeat resection of pulmonary metastases in patients with soft-tissue sarcoma. J Am Coll Surg. 2000;191:184–90.

    Article  CAS  PubMed  Google Scholar 

  20. Nakamura T, Matsumine A, Yamakado K, Matsubara T, Takaki H, Nakatsuka A, et al. Lung radiofrequency ablation in patients with pulmonary metastases from musculoskeletal sarcomas. Cancer. 2009;115:3774–81.

    Article  PubMed  Google Scholar 

  21. Navarria P, Ascolese AM, Cozzi L, Tomatis S, D’Agostino GR, De Rose F, et al. Stereotactic body radiation therapy for lung metastases from soft tissue sarcoma. Eur J Cancer. 2015;51:668–74.

    Article  PubMed  Google Scholar 

  22. Mehta N, Selch M, Wang PC, Federman N, Lee JM, Eilber FC, et al. Safety and efficacy of stereotactic body radiation therapy in the treatment of pulmonary metastases from high grade sarcoma. Sarcoma. 2013;2013:360214. doi:10.1155/2013/360214.

    Article  PubMed  PubMed Central  Google Scholar 

  23. Soyfer V, Corn BW, Shtraus N, Honig N, Meir Y, Kollender J, et al. Single-institution experience of SBRT for lung metastases in sarcoma patients. Am J Clin Oncol. 2014. doi:10.1097/COC.0000000000000103.

  24. Dhakal S, Corbin KS, Milano MT, Philip A, Sahasrabudhe D, Jones C, et al. Stereotactic body radiotherapy for pulmonary metastases from soft-tissue sarcomas: excellent local lesion control and improved patient survival. Int J Radiat Oncol Biol Phys. 2012;82:940–5.

    Article  PubMed  Google Scholar 

  25. Koelblinger C, Strauss S, Gillams A. Outcome after radiofrequency ablation of sarcoma lung metastases. Cardiovasc Intervent Radiol. 2014;37:147–53.

    Article  PubMed  Google Scholar 

  26. de Baère T. Lung tumor radiofrequency ablation: where do we stand? Cardiovasc Intervent Radiol. 2011;34:241–51.

    Article  PubMed  Google Scholar 

  27. Zhu JC, Yan TD, Morris DL. A systematic review of radiofrequency ablation for lung tumors. Ann Surg Oncol. 2008;15:1765–74.

    Article  PubMed  Google Scholar 

  28. Lencioni R, Crocetti L, Cioni R, Suh R, Glenn D, Regge D, et al. Response to radiofrequency ablation of pulmonary tumours: a prospective, intention-to-treat, multicentre clinical trial (the RAPTURE study). Lancet Oncol. 2008;9:621–8.

    Article  PubMed  Google Scholar 

  29. Simon CJ, Dupuy DE, DiPetrillo TA, Safran HP, Grieco CA, Ng T, et al. Pulmonary radiofrequency ablation: long-term safety and efficacy in 153 patients. Radiology. 2007;243:268–75.

    Article  PubMed  Google Scholar 

  30. Sano Y, Kanazawa S, Gobara H, Mukai T, Hiraki T, Hase S, et al. Feasibility of percutaneous radiofrequency ablation for intrathoracic malignancies: a large single-center experience. Cancer. 2007;109:1397–405.

    Article  PubMed  Google Scholar 

  31. Kashima M, Yamakado K, Takaki H, Kodama H, Yamada T, Uraki J, et al. Complications after 1000 lung radiofrequency ablation sessions in 420 patients: a single center’s experiences. AJR Am J Roentgenol. 2011;197:W576–80.

    Article  PubMed  Google Scholar 

  32. Hiraki T, Mimura H, Gobara H, Sano Y, Fujiwara H, Date H, et al. Repeat radiofrequency ablation for local progression of lung tumors: does it have a role in local tumor control? J Vasc Interv Radiol. 2008;19:706–11.

    Article  PubMed  Google Scholar 

  33. Tochio M, Takaki H, Yamakado K, Uraki J, Kashima M, Nakatsuka A, et al. A case report of 20 lung radiofrequency ablation sessions for 50 lung metastases from parathyroid carcinoma causing hyperparathyroidism. Cardiovasc Intervent Radiol. 2010;33:657–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Okayama University Medical School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Takuya Sato, Toshihiro Iguchi, Takao Hiraki, Hideo Gobara, Hiroyasu Fujiwara, Yusuke Matsui & Susumu Kanazawa

  2. Center for Innovative Clinical Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Jun Sakurai & Toshiharu Mitsuhashi

  3. General Thoracic Surgery, Okayama University Medical School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Junichi Soh & Shinichi Toyooka

  4. Clinical Genomic Medicine, Okayama University Medical School, 2-5-1 Shikata-cho, Kita-ku, Okayama, 700-8558, Japan

    Shinichi Toyooka

Authors
  1. Takuya Sato
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Toshihiro Iguchi
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Takao Hiraki
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Hideo Gobara
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiroyasu Fujiwara
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jun Sakurai
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Yusuke Matsui
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Toshiharu Mitsuhashi
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Junichi Soh
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Shinichi Toyooka
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Susumu Kanazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Toshihiro Iguchi.

Ethics declarations

Conflict of interest

The authors declare no conflicts of interest or funding sources to disclose. The ethics committee at our institutional approved this retrospective study.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sato, T., Iguchi, T., Hiraki, T. et al. Radiofrequency ablation of pulmonary metastases from sarcoma: single-center retrospective evaluation of 46 patients. Jpn J Radiol 35, 61–67 (2017). https://doi.org/10.1007/s11604-016-0601-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11604-016-0601-z

Keywords

Search

Navigation