Abstract
Bone scintigraphy with technetium-99m (99mTc)-labeled diphosphonates is one of the most frequently performed radionuclide procedures. Accumulation of 99mTc-labeled diphosphonate is well recognized to reflect conditions of accelerated bone turnover and metabolism. Therefore, it is a functional imaging modality for detecting metastatic bone tumors, metabolic bone disease, traumatic injury, and inflammation. This pictorial essay describes the possible patterns of distribution of abnormal uptake for differential diagnosis of metastatic bone tumor, as well as the diagnostic pitfalls of bone scintigraphy.
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References
Brenner AI, Koshy J, Morey J, Lin C, DiPoce J. The bone scan. Semin Nucl Med. 2012;42:11–26.
Roodman GD. Mechanisms of bone metastasis. N Engl J Med. 2004;15:1655–64.
Love C, Din AS, Tomas MB, Kalapparambath TP, Palestro CJ. Radionuclide bone imaging: an illustrative review. Radiographics. 2003;23:341–58.
Yamaguchi T, Tamai K, Yamato M, Honma K, Ueda Y, Saotome K. Intertrabecular pattern of tumors metastatic to bone. Cancer. 1996;78:1388–94.
Murray IP, Dixon J. The role of single photon emission computed tomography in bone scintigraphy. Skelet Radiol. 1989;18:493–505.
Ryan PJ, Fogelman I. Bone scintigraphy in metabolic bone disease. Semin Nucl Med. 1997;27:291–305.
Fogelman I, Collier BD, Brown ML. Bone scintigraphy: part 3. Bone scanning in metabolic bone disease. J Nucl Med. 1993;34:2247–52.
Cook GJ, Gnanasegaran G, Chua S. Miscellaneous indications in bone scintigraphy: metabolic bone diseases and malignant bone tumors. Semin Nucl Med. 2010;40:52–61.
Meydan N, Barutca S, Guney E, Boylu S, Savk O, Culhaci N, et al. Brown tumors mimicking bone metastases. J Natl Med Assoc. 2006;98:950–3.
Collins MT, Riminucci M, Banco P. Fibrous dysplasia. In: Rosen CJ, editor. Primer on the metabolic bone diseases and disorders of mineral metabolism. 7th ed. Washington, D.C.: American Society for Bone and Mineral Research; 2008. p. 423–7.
Bousson V, Rey-Jouvin C, Laredo JD, Le Merrer M, Martin-Duverneuil N, Feydy A, et al. Fibrous dysplasia and McCune-Albright syndrome: imaging for positive and differential diagnoses, prognosis, and follow-up guidelines. Eur J Radiol. 2014;83:1828–42.
Brown ML, Collier BD Jr, Fogelman I. Bone scintigraphy: part 1. Oncology and infection. J Nucl Med. 1993;34:2236–40.
Love C, Palestro CJ. Radionuclide imaging of inflammation and infection in the acute care setting. Semin Nucl Med. 2013;43:102–13.
Collier BD Jr, Fogelman I, Brown ML. Bone scintigraphy: part 2. Orthopedic bone scanning. J Nucl Med. 1993;34:2241–6.
Van der Wall H, Murray IPC. Bone scintigraphy in trauma. In: Ell PJ, Gambhir SS, editors. Nuclear medicine in clinical diagnosis and treatment. 3rd ed. London: Churchill Livingstone; 2005. p. 709–20.
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Tsubaki, F., Kurata, S., Nagata, S. et al. Clinical spectrum and diagnostic pitfalls of multiple abnormal uptakes on bone scintigraphy. Jpn J Radiol 34, 771–778 (2016). https://doi.org/10.1007/s11604-016-0585-8
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DOI: https://doi.org/10.1007/s11604-016-0585-8