Skip to main content

Advertisement

Log in

Mediastinal paraganglioma

  • Case Report
  • Published:
Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

We present a case of mediastinal paraganglioma with radiologic–pathologic correlation. A 48-year-old woman was found incidentally to have a middle mediastinal mass on CT. The mass showed iso-signal intensity compared to that of muscle on T1-weighted images and high signal intensity on T2-weighted images. The lesion showed intermediate intensity on diffusion-weighted imaging, and its apparent diffusion coefficient was 1.72 × 10−3 mm2/s. A contrast-enhanced dynamic study revealed a rapid peak and washout enhancement pattern. 18F-FDG-PET revealed abnormal uptake in the mediastinal tumor with a maximal standardized uptake value of 7.88. 123I-meta-iodobenzylguanidine scintigraphy also showed abnormal uptake in the tumor. These findings corresponded to the hypervascularity, rich stroma, low nuclear/cytoplasmic ratio, and nest-forming proliferation of tumor cells with positive neuroendocrine markers.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Balcombe J, Torigian DA, Kim W, Miller WT. Cross-sectional imaging of paragangliomas of the aortic body and other thoracic brachiometric paraganglia. AJR Am J Roentgenol. 2007;188:1054–8.

    Article  PubMed  Google Scholar 

  2. Yamamoto J, Masuda D, Shimanouchi M, Hashizume T, Numata T, Shiozawa T, et al. A case of middle mediastinal paraganglioma. JJSRE. 2010;32:285–90 (in Japanese with English abstract).

    Google Scholar 

  3. Blandino A, Salvi L, Faranda C, Spadaro P, Perrotta F, Maiello F, et al. Usual malignant paraganglioma of the anterior mediastinum: CT and MR findings. Eur J Radiol. 1992;15:1–3.

    Article  CAS  PubMed  Google Scholar 

  4. Flickinger FW, Yuh WT, Behrendt DM. Magnetic resonance imaging of mediastinal paraganglioma. Chest. 1988;94:652–4.

    Article  CAS  PubMed  Google Scholar 

  5. Paul S, Jain SH, Gallegos RP, Aranki SF, Bueno R. Functional paraganglioma of the middle mediastinum. Ann Thorac Surg. 2007;83:e14–6.

    Article  PubMed  Google Scholar 

  6. Wang H, Ye H, Guo A, Wei Z, Zhang X, Zhong Y, et al. Bladder paraganglioma in adults: MR appearance in four patients. Eur J Radiol. 2011;80:e217–20.

    Article  PubMed  Google Scholar 

  7. Aschenbach R, Basche S, Vogl TJ, Klisch J. Diffusion-weighted imaging and ADC mapping of head-and-neck paragangliomas: initial experience. Klin Neuroradiol. 2009;19:215-9.

    Article  PubMed  Google Scholar 

  8. Hatakenaka M, Soeda H, Yabuuchi H, Matuso Y, Kamitnai T, Oda Y, et al. Apparentdiffusion coefficients of breast tumors: clinical application. Magn Reson Med Sci. 2008;7:23–9.

    Article  PubMed  Google Scholar 

  9. Uhl M, Altehoefer C, Kontny U, Il’yasov K, Buchert M, Langer M. MRI-diffusion imaging of neuroblastomas: first results and correlation to histology. Eur Radiol. 2002;12:2335–8.

    Article  CAS  PubMed  Google Scholar 

  10. Matsumoto J, Tanaka N, Yoshida Y, Yamamoto T. Resection of an intrapericardial paraganglioma under cardiopulmonary bypass. Asian Cardiovasc Thorac Ann. 2013;21:476–8.

    Article  PubMed  Google Scholar 

  11. Taieb D, Neumann H, Rubello D, Al-Nahhas A, Guillet B, Hindie E. Modern nuclear imaging for paragangliomas: beyond SPECT. J Nucl Med. 2012;53:264–74.

    Article  CAS  PubMed  Google Scholar 

  12. Lee KY, Oh YW, Noh HJ, Lee YJ, Yong HS, Kang EY, et al. Extraaderenal paragangliomas of the body: imaging features. AJR Am J Roentgenol. 2006;187:492–504.

    Article  PubMed  Google Scholar 

  13. Whitten CR, Khan S, Munneke GF, Grubnic S. A diagnostic approach to mediastinal abnormalities. Radiographics. 2007;27:657–71.

    Article  PubMed  Google Scholar 

  14. Madan R, Chen JH, Dickenson BT, Jacobson F, Hunsaker A. The spectrum of Castleman’s disease: mimics, radiologic pathologic correlation and role of imaging in patient management. Eur J Radiol. 2012;81:123–31.

    Article  PubMed  Google Scholar 

  15. Khalil G, Gaspard D, Jreige M, Nawfal G. Diffusion-weighted whole-body imaging with background body signal suppression in Castleman’s disease. Clin Imag. 2013;37:185–8.

    Article  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Takeshi Kamitani.

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Takashima, Y., Kamitani, T., Kawanami, S. et al. Mediastinal paraganglioma. Jpn J Radiol 33, 433–436 (2015). https://doi.org/10.1007/s11604-015-0436-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11604-015-0436-z

Keywords

Navigation