Abstract
Purpose
To evaluate the feasibility of the iterative reconstruction (IR) method with low-dose multi-detector computed tomography (MDCT) for lung cancer screening.
Materials and methods
A chest CT phantom containing simulated ground-glass nodules (GGNs) of 5 different sizes was scanned by use of 16-row and 64-row MDCT. Tube currents of 10, 20, and 30 mA were used for the low-dose CT. To assess the detectability of pure GGNs, a radiologist-performance test was conducted. Mean visual scores for simulated GGNs were compared for reconstructed images from filtered back-projection (FBP) and the IR method.
Results
When 64-row MDCT was used, visual scores for simulated GGNs were significantly higher for the IR method than for the FBP method under any conditions; scores were also significantly higher for 16-row MDCT under some conditions.
Conclusions
The results of this experimental chest phantom study showed that use of the IR method improved the detectability of simulated pure GGNs.
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Acknowledgments
The authors would like to thank F. Suzuki, MD, T. Hara, MD, N. Niiya, MD, H. Fujisawa, MD, J. Watari, MD, and T. Ikegmi, MD for their participation in our radiologist-performance test, T. Iinuma, MD, for advice about our study, and M. Taguri, Ph.D. and M. Saito, for statistical analysis. This research was not supported by any external funding.
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The authors declare that they have no conflicts of interest.
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Akashita, S., Tachibana, Y., Sakamaki, K. et al. Detection of pure ground-glass nodules in the lung by low-dose multi-detector computed tomography, with use of an iterative reconstruction method: a comparison with conventional image reconstruction by the filtered back-projection method. Jpn J Radiol 33, 113–121 (2015). https://doi.org/10.1007/s11604-014-0384-z
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DOI: https://doi.org/10.1007/s11604-014-0384-z