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Correlation of metabolic tumor volume and 11C-choline uptake with the pathology of prostate cancer: evaluation by use of simultaneously recorded MR and PET images

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Abstract

Purpose

This study was conducted to assess the relationship between 11C-choline uptake and pathologic findings obtained by combined use of magnetic resonance (MR) and positron emission tomography (PET) imaging of patients with prostate cancer.

Materials and methods

We retrospectively evaluated 69 patients with prostate cancer who underwent 11C-choline PET-CT and magnetic resonance imaging before radical prostatectomy. Combined MR–PET images were acquired to obtain precise anatomic information. The maximum standardized uptake value (SUVmax) and metabolic tumor volume (MTV) were compared with pathologic findings from resected specimens as the reference standard.

Results

The mean and standard deviation of tumor SUVmax and MTV were 3.9 ± 1.8 and 12.9 ± 16.4, respectively. Tumors with high MTV (≧8.2) were more likely to be admixed with prostatic intraepithelial neoplasia (PIN) (p < 0.0001) or hyperplasia (p < 0.0001) in the background than those without these findings. Multiple regression analysis also revealed that the presence of hyperplasia (OR; 4.25, 95 % CI 1.25–14.4, p = 0.02) and PIN (OR; 9.22, 95 % CI 2.60–32.7, p = 0.001) were associated with tumors with high MTV.

Conclusion

We have demonstrated, by pathologic evaluation of patients with prostate cancer, that 11C-choline uptake volume is greater for prostate cancer admixed with PIN and hyperplasia than that without.

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Acknowledgments

This work was supported (in part) by a Grant-in-Aid for Cancer Research (21-5-2) from the Ministry of Health, Labor and Welfare.

Conflict of interest

The authors declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology, Graduate School of Medicine, Yokohama City University, 3-9, Fukuura, Kanazawa-ku, Yokohama, Kanagawa, 236-0004, Japan

    Tomohiro Yoneyama, Ukihide Tateishi & Tomio Inoue

  2. Division of Cancer Screening, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, Japan

    Takashi Terauchi

Authors
  1. Tomohiro Yoneyama
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  2. Ukihide Tateishi
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  3. Takashi Terauchi
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  4. Tomio Inoue
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Corresponding author

Correspondence to Ukihide Tateishi.

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Yoneyama, T., Tateishi, U., Terauchi, T. et al. Correlation of metabolic tumor volume and 11C-choline uptake with the pathology of prostate cancer: evaluation by use of simultaneously recorded MR and PET images. Jpn J Radiol 32, 155–163 (2014). https://doi.org/10.1007/s11604-014-0283-3

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  • DOI: https://doi.org/10.1007/s11604-014-0283-3

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