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EBV-positive MTX-diffuse large B cell lymphoma in a rheumatoid arthritis patient

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Abstract

Methotrexate (MTX)-associated lymphoproliferative disorders have received much attention from rheumatologists, and early diagnosis is very important for reducing mortality. There are several reports of radiologic findings in patients with pulmonary malignant lymphoma, mainly consisting of masses, nodules, and lymphadenopathy. Computed tomography has rarely detected necrosis in the masses. In this article, we report a case of MTX-associated Epstein–Barr virus-positive diffuse large B-cell lymphoma characterized by a very large lung mass with prominent areas of central necrosis. The disease regressed after withdrawal of MTX.

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Conflict of interest

None of the authors has a direct or indirect financial interest in the products under investigation or in the subject matter discussed in this article.

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Authors and Affiliations

  1. Department of Radiology, Faculty of Medicine, Oita University, 1-1 Idaigaoka, Hasama-machi, Yufu, Oita, 879-5593, Japan

    Kouhei Tokuyama, Fumito Okada, Shunro Matsumoto & Hiromu Mori

  2. Department of Hematology, Faculty of Medicine, Oita University, Oita, Japan

    Masao Ogata

  3. Department of Respiratory, Oita Prefectural Hospital, Oita, Japan

    Erika Omote & Toru Yamasaki

  4. Department of Pathology, Oita Prefectural Hospital, Oita, Japan

    Syougo Urabe

Authors
  1. Kouhei Tokuyama
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  2. Fumito Okada
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  3. Shunro Matsumoto
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  4. Hiromu Mori
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  5. Masao Ogata
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  6. Erika Omote
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  7. Toru Yamasaki
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  8. Syougo Urabe
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Corresponding author

Correspondence to Kouhei Tokuyama.

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Tokuyama, K., Okada, F., Matsumoto, S. et al. EBV-positive MTX-diffuse large B cell lymphoma in a rheumatoid arthritis patient. Jpn J Radiol 32, 183–187 (2014). https://doi.org/10.1007/s11604-013-0280-y

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  • DOI: https://doi.org/10.1007/s11604-013-0280-y

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