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Prediction of postoperative pulmonary function: preliminary comparison of single-breath dual-energy xenon CT with three conventional methods

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Abstract

Purpose

To assess the use of xenon ventilation maps (Xe-images) for predicting postoperative pulmonary function.

Materials and methods

After study approval by the institutional review board, written informed consent was obtained from 30 patients with lung tumors who underwent pre- and postoperative spirometry, pulmonary perfusion SPECT and dual-energy CT (80 kV and 140 kV/Sn) after single-breath inspiration of 35 % xenon. Xe-images were calculated by three-material decomposition. Sum of pixel values of the part to be resected (A) and of the whole lung (B) on Xe-images or lung perfusion SPECT, and volumes or the number of segments of the part to be resected (A) and of the whole lung (B) on Xe-images were enumerated, respectively. We multiplied (1 − A/B) by each preoperative value from spirometry for prediction. Predictions by each of the four methods were compared with postoperative values.

Results

Predicted values for vital capacity (VC), forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV1) by the four methods regressed significantly with measured values (R 2 = 0.56–0.77, p < 0.001 for all).

Conclusion

Analysis of Xe-images can predict postoperative VC, FVC and FEV1 with accuracy comparable to that of CT volumetry.

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Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Radiology, Saitama Medical Center, Saitama Medical University, 1981 Kamoda, Kawagoe, Saitama, 350-8550, Japan

    Hisami Yanagita, Norinari Honda, Wataru Watanabe, Yuji Shimizu, Hisato Osada, Kei Nakada, Takemichi Okada, Hitoshi Ohno & Takeo Takahashi

  2. Department of Thoracic Surgery, Saitama Medical Center, Saitama Medical University, Kawagoe, Japan

    Mitsuo Nakayama

  3. Siemens Japan KK Healthcare, West Tower, Gate City Ohsaki, 1-11-1 Ohsaki, Shinagawa, Tokyo, 141-8644, Japan

    Katharina Otani

Authors
  1. Hisami Yanagita
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  2. Norinari Honda
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  3. Mitsuo Nakayama
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  4. Wataru Watanabe
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  5. Yuji Shimizu
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  6. Hisato Osada
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  7. Kei Nakada
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  8. Takemichi Okada
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  9. Hitoshi Ohno
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  10. Takeo Takahashi
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  11. Katharina Otani
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Corresponding author

Correspondence to Hisami Yanagita.

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Yanagita, H., Honda, N., Nakayama, M. et al. Prediction of postoperative pulmonary function: preliminary comparison of single-breath dual-energy xenon CT with three conventional methods. Jpn J Radiol 31, 377–385 (2013). https://doi.org/10.1007/s11604-013-0202-z

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  • DOI: https://doi.org/10.1007/s11604-013-0202-z

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