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Evaluation of chronic ischemic heart disease with myocardial perfusion and regional contraction analysis by contrast-enhanced 256-MSCT

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Abstract

Purpose

To investigate myocardial viability in chronic ischemic heart disease by myocardial perfusion and regional contraction analysis using 256-slice MSCT coronary angiography (CCTA).

Methods

In 30 patients with prior myocardial infarction (MI), CCTA with retrospective ECG-gating and stress-redistribution thallium-201 SPECT were performed. Using the same raw data as used for CCTA, myocardial perfusion imaging (CT-MPI) was reconstructed at four phases during the cardiac cycle. Mean myocardial attenuation and wall thickness at end-systole and end-diastole were measured in the MI areas depicted by SPECT, and they were compared between viable and non-viable segments categorized by SPECT.

Results

End-systolic thickness was significantly greater for viable than for non-viable segments (12.0 ± 3.2 vs. 9.6 ± 3.5 mm, p = 0.0017). There was no difference in end-diastolic thickness. Myocardial attenuation was significantly higher for viable than for non-viable segments in the subendocardium (62 ± 13 vs. 70 ± 11 HU, p = 0.003) and the epicardium (65 ± 13 vs. 80 ± 15 HU, p = 0.0002).

Conclusion

The systolic wall thinning and epicardial low-attenuation areas were the indicative findings of CT-MPI for non-viable segments in the prior MI.

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Authors and Affiliations

  1. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Ko Higuchi, Yoshio Matsuo, Takeshi Kamitani, Masato Yonezawa, Mikako Jinnouchi, Yuzo Yamasaki, Koichiro Abe, Shingo Baba & Hiroshi Honda

  2. Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, Fukuoka, 812-8582, Japan

    Michinobu Nagao

  3. Department of Cardiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Yasushi Mukai, Taiki Higo & Kenji Sunagawa

Authors
  1. Ko Higuchi
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  2. Michinobu Nagao
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  3. Yoshio Matsuo
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  4. Takeshi Kamitani
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  9. Shingo Baba
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  13. Hiroshi Honda
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Correspondence to Michinobu Nagao.

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Higuchi, K., Nagao, M., Matsuo, Y. et al. Evaluation of chronic ischemic heart disease with myocardial perfusion and regional contraction analysis by contrast-enhanced 256-MSCT. Jpn J Radiol 31, 123–132 (2013). https://doi.org/10.1007/s11604-012-0159-3

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  • DOI: https://doi.org/10.1007/s11604-012-0159-3

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