Skip to main content

Advertisement

SpringerLink
Log in

Swine-origin influenza A viral (H1N1) infection in children: chest computed tomography findings

  • Original Article
  • Published:
Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to review the chest computed tomography (CT) findings in children with swine-origin influenza (H1N1) virus (S-OIV) infection.

Materials and methods

The radiologists retrospectively reviewed chest CT findings in 12 children with S-OIV infection and recorded the following findings: ground-glass opacities (GGO), consolidation, nodules, reticular opacities, peribronchial cuffing, and air trapping; distribution; affected lobes. The presence of pleural effusions, pneumomediastinum, pulmonary interstitial emphysema (PIE), and lymphadenopathy was also recorded.

Results

Chest CT revealed GGO (67%), consolidation (67%), nodules (25%), peribronchial cuffing (42%), and air trapping (33%). The distribution of the lesions was random (75%), peribronchial (17%), or subpleural (8%). The lobes affected were the lower (92%), upper (58%), and middle (17%) lobes. There were associated pleural effusions (42%), PIE (42%), pneumomediastinum (33%), and lymphadenopathy (75%). Among five patients with air-leak complications, three had a history of allergies and three required the intensive care unit.

Conclusion

Chest CT findings in children with S-OIV infection were peribronchial thickening and a mixture of airspace consolidation and GGO with random distribution and lower lobe predominance. Pleural effusion, lymphadenopathy, PIE, and pneumomediastinum may be associated findings.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Novel Swine-Origin Influenza A (H1N1) Virus Investigation Team. Emergence of a novel swine-origin influenza A (H1N1) virus in humans. N Engl J Med 2009;360:2605–2615.

    Article  Google Scholar 

  2. Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, Hernandez M, Quiñones-Falconi F, Bautista E, et al. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med 2009;361:680–693.

    Article  PubMed  CAS  Google Scholar 

  3. World Health Organization Website. Global alert and response: pandemic (H1N1) 2009-update 112. Available at: www.who.int/csr/don/2010_08_06/en/index.html. Assessed November 10, 2010.

  4. Lee EY, McAdam AJ, Chaudry G, Fishman MP, Zurakowski D, Boiselle PM. Swine-origin influenza A (H1N1) viral infection in children: initial chest radiographic finding. Radiology 2010;254:934–941.

    Article  PubMed  Google Scholar 

  5. Hasegawa M, Hashimoto K, Morozumi M, Ubukata K, Takahashi T, Inamo Y. Spontaneous pneumomediastinum complicating pneumonia in children infected with the 2009 pandemic influenza A (H1N1) virus. Clin Microbiol Infect 2010;16:195–199.

    Article  PubMed  CAS  Google Scholar 

  6. O’Riordan S, Barton M, Yau Y, Read SE, Allen U, Tran D. Risk factors and outcomes among children admitted to hospital with pandemic H1N1 influenza. CMAJ 2010;182:39–44.

    Article  PubMed  Google Scholar 

  7. Agarwal PP, Cinti S, Kazerooni EA. Chest radiographic and CT findings in novel swine-origin influenza A (H1N1) virus (S-OIV) infection. AJR Am J Roentgenol 2009;193:1488–1493.

    Article  PubMed  Google Scholar 

  8. Andronikou S. Pathological correlation of CT-detected mediastinal lymphadenopathy in children: the lack of size threshold criteria for abnormality. Pediatr Radiol 2002;32:912.

    Article  PubMed  Google Scholar 

  9. Mollura DJ, Asnis DS, Crupi RS, Conetta R, Felgin DS, Bray M, et al. Imaging findings in a fatal case of pandemic swine-origin influenza A (H1N1). AJR Am J Roentgenol 2009;193:1500–1503.

    Article  PubMed  Google Scholar 

  10. Ajlan AM, Quiney B, Nicolaou S, Muller NL. Swine-origin influenza A (H1N1) viral infection: radiographic and CT findings. AJR Am J Roentgenol 2009;193:1494–1499.

    Article  PubMed  Google Scholar 

  11. Hancock K, Veguilla V, Lu X, Zhong W, Butter EN, Sun H, et al. Cross-reactive antibody responses to the 2009 pandemic H1N1 influenza virus. N Engl J Med 2009;361:1945–1952.

    Article  PubMed  CAS  Google Scholar 

  12. Lessler J, Reich NG, Cummings DA; New York City Department of Health and Mental Hygiene Swine Influenza Investigation Team, Nair HP, Jordan HT, Thompson N. Outbreak of 2009 pandemic influenza A (H1N1) at a New York City school. N Engl J Med 2009;361:2628–2636.

    Article  PubMed  CAS  Google Scholar 

  13. Elicker BM, Schwartz BS, Liu C, Chen EC, Miller SA, Chiu CY, et al. Thoracic CT findings of novel influenza A (H1N1) infection in immunocompromised patients. Emerg Radiol 2010;17:299–307.

    Article  PubMed  Google Scholar 

  14. Takahashi T, Hoshino Y, Nakamura T, Iwamoto A. Mediastinal emphysema with Pneumocystis carinii pneumonia in AIDS. AJR Am J Roentgenol 1997;169:1465–1466.

    PubMed  CAS  Google Scholar 

  15. Rumbak MJ, Winer-Muram HT, Beals DH, Fry P. Tension pneumomediastinum complicating Pneumocystis carinii pneumonia in acquired immunodeficiency syndrome. Crit Care Med 1992;20:1492–1494.

    Article  PubMed  CAS  Google Scholar 

  16. Binder L, Mihaly J. Mediastinal emphysema developed in status asthmaticus associated with influenza. Orv Hetil 1959;100:436–438.

    PubMed  CAS  Google Scholar 

  17. Marchiori E, Zanetti G, D’Ippolito G, Verrastro CG, de Souza Portes Meirelles G, Capobianco J, et al. Swine-origin influenza A (H1N1) viral infection: thoracic findings on CT. AJR Am J Roentgenol 2011;196:723–728.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701, Republic of Korea

    Soo Ah Im, Hyo Lim Kim & Ho Jong Chun

  2. Department of Pediatrics, Seoul St. Mary’s Hospital, The Catholic University of Korea, Seoul, Republic of Korea

    Jong-seo Yoon, Jin Han Kang & Joon-Sung Lee

Authors
  1. Soo Ah Im
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Hyo Lim Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jong-seo Yoon
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Jin Han Kang
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Joon-Sung Lee
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Ho Jong Chun
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ho Jong Chun.

About this article

Cite this article

Im, S.A., Kim, H.L., Yoon, Js. et al. Swine-origin influenza A viral (H1N1) infection in children: chest computed tomography findings. Jpn J Radiol 29, 707–711 (2011). https://doi.org/10.1007/s11604-011-0619-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11604-011-0619-1

Key words

Search

Navigation