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Pneumothorax and idiopathic pulmonary fibrosis

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Abstract

Purpose

We evaluated the relation between the severity of idiopathic pulmonary fibrosis (IPF) and the incidence of pneumothorax on computed tomography (CT) images.

Materials and methods

In this retrospective study, we evaluated the presence of pneumothorax in 56 consecutive patients who died of IPF from the initial CT to death. We quantitatively analyzed a total of 207 CT images and measured the volume of the normal pattern (N-pattern) and each lesion pattern on the initial CT and their serial changes. The effects of pneumothorax and clinical and CT features on survival were evaluated using Cox regression analysis.

Results

Pneumothorax occurred in 17 of 56 patients. Comparison of the pneumothorax (+) and (-) groups showed the initial vital capacity (VC) was lower (P = 0.005) and the follow-up period was shorter (P = 0.03) in the former group. The decrease in the N-pattern volume in the pneumothorax(+) group was significantly faster than in the pneumothorax(-) group (P = 0.013). Cox regression analyses identified a rapid decrease in N-pattern volume (P = 0.008) and a rapid decrease in VC (P = 0.002), but not pneumothorax, as significant predictors of poor survival.

Conclusion

Pneumothorax in IPF patients is associated with lower VC and rapid deterioration of CT findings. The findings suggest that pneumothorax is a complication of advanced IPF.

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Authors and Affiliations

  1. Department of Radiology, Kanagawa Cardiovascular and Respiratory Center, 6-16-1 Tomioka-Higashi, Kanazawa-ku, Yokohama, 236-8651, Japan

    Tae Iwasawa

  2. Department of Respiratory Medicine, Kanagawa Cardiovascular and Respiratory Center, Yokohama, Japan

    Takashi Ogura & Hiroshi Takahashi

  3. Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama, Japan

    Akira Asakura & Toshiyuki Gotoh

  4. Department of Pathology, Yokohama City University, School of Medicine, Yokohama, Japan

    Takuya Yazawa

  5. Department of Radiology, Yokohama City University, School of Medicine, Yokohama, Japan

    Tomio Inoue

Authors
  1. Tae Iwasawa
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  2. Takashi Ogura
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  3. Hiroshi Takahashi
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  4. Akira Asakura
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  5. Toshiyuki Gotoh
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  6. Takuya Yazawa
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  7. Tomio Inoue
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Corresponding author

Correspondence to Tae Iwasawa.

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Iwasawa, T., Ogura, T., Takahashi, H. et al. Pneumothorax and idiopathic pulmonary fibrosis. Jpn J Radiol 28, 672–679 (2010). https://doi.org/10.1007/s11604-010-0494-1

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  • DOI: https://doi.org/10.1007/s11604-010-0494-1

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