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Malignant solitary fibrous tumor of the pleura: computed tomography-pathological correlation and comparison with computed tomography of benign solitary fibrous tumor of the pleura

Abstract

Purpose

The aim of this study was to determine the computed tomography (CT)-pathological correlation of malignant solitary fibrous tumors of the pleura (MSFP) and to compare these findings with CT findings of benign solitary fibrous tumors of the pleura (BSFTP).

Materials and methods

We retrospectively identified the clinical, CT, and pathological findings in seven cases of MSFP. There was a CT-pathological correlation for the MSFPs. Additionally, 12 cases of BSFTP from case files were compared with the clinical and CT features of the MSFPs.

Results

On CT, the MSFP appeared as a heterogeneously enhancing mass >10 cm (100%). Pleural metastasis (57.1%) and lung metastasis (14.3%) were associated. In the CT-pathological correlation, the enhancing area was mixed cellular and collagenous tissue with hypercellularity, mitosis, and pleomorphism. Hemorrhage, necrosis, cystic, or myxoid degeneration produced areas of intratumoral low attenuation. MSFPs showed a higher incidence of intratumoral low-attenuation areas (P = 0.034) and pleural metastasis (P = 0.009); and on CT, MSFPs tended to be larger than BSFTPs (P = 0.076).

Conclusion

MSFPs showed a >10 cm pleural mass with low-attenuation regions on CT, which corresponded to hemorrhage, necrosis, cystic, or myxoid degeneration. MSFPs had a higher incidence of intratumoral lowattenuation areas and pleural metastasis, and on CT they tended to be larger than BSFTPs.

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References

  1. England DM, Hochholzer L, McCarthy MJ. Localized benign and malignant fibrous tumors of the pleura: a clinicopathologic review of 223 cases. Am J Surg Pathol 1989;13:640–658.

    CAS  Article  PubMed  Google Scholar 

  2. Cardillo G, Facciolo F, Cavazzana AO, Capece G, Gasparri R, Martelli M. Localized (solitary) fibrous tumors of the pleura: an analysis of 55 patients. Ann Thorac Surg 2000;70:1808–1812.

    CAS  Article  PubMed  Google Scholar 

  3. Hanau CA, Miettinen M. Solitary fibrous tumor: histological and immunohistochemical spectrum of benign and malignant variants presenting at different sites. Hum Pathol 1995;26:440–449.

    CAS  Article  PubMed  Google Scholar 

  4. Magdeleinat P, Alifano M, Petino A, Le Rochais J, Dulmet E, Galateau F, et al. Solitary fibrous tumors of the pleura: clinical characteristics, surgical treatment and outcome Eur J Cardiothorac Surg 2002;21:1087–1093.

    Article  PubMed  Google Scholar 

  5. Gold JS, Antonescu CR, Hajdu C, Ferrone CR, Hussain M, Lewis JJ, et al. Clinicopathologic correlates of solitary fibrous tumors Cancer 2002;94:1057–1068.

    Article  PubMed  Google Scholar 

  6. De Perrot M, Fischer S, Bründler M, Sekine Y, Keshavjee S. Solitary fibrous tumors of the pleura. Ann Thorac Surg 2002;74:285–293.

    Article  PubMed  Google Scholar 

  7. Lee KS, Im J, Choe KO, Kim CJ, Lee BH. CT findings in benign fibrous mesothelioma of the pleura: pathologic correlation in nine patients. AJR Am J Roentgenol 1992;158:983–986.

    CAS  PubMed  Google Scholar 

  8. Ferretti GR, Chiles C, Choplin RH, Coulomb M. Localized benign fibrous tumors of the pleura. AJR Am J Roentgenol 1997;169:683–686.

    CAS  PubMed  Google Scholar 

  9. Desser TS, Stark P. Pictorial essay: solitary fibrous tumor of the pleura. Thorac Imaging 1998;13:27–35.

    CAS  Article  Google Scholar 

  10. Ferretti GR, Chiles C, Cox JE, Chopline RH, Coulomb M. Localized benign fibrous tumors of the pleura: MR appearance. J Comput Assist Tomogr 1997;21:115–120.

    CAS  Article  PubMed  Google Scholar 

  11. Mendelson DS, Meary E, Buy JN, Pigeau I, Kirschner PA. Localized fibrous pleural mesothelioma: CT findings. Clin Imaging 1991;15:105–108.

    CAS  Article  PubMed  Google Scholar 

  12. Rosado-de-Christenson ML, Abbott GF, McAdams HP, Franks TJ, Galvin JR. From the archives of the AFIP: localized fibrous tumors of the pleura. Radiographics 2003;23:759–783.

    Article  PubMed  Google Scholar 

  13. Saifuddin A, Costa PD, Chalmers AG, Carey BM, Robertson RJH. Primary malignant localized fibrous tumors of the pleura: clinical, radiological, and pathological features. Clin Radiol 1992;45:13–17.

    CAS  Article  PubMed  Google Scholar 

  14. Bonomo L, Feragalli B, Sacco R, Merlino B, Storto ML. Malignant pleural disease. Eur J Radiol 2000;34:98–118.

    CAS  Article  PubMed  Google Scholar 

  15. Briselli M, Mark EJ, Dickersin GR. Solitary fibrous tumors of the pleura: eight new cases and review of 360 cases in the literature. Cancer 1981;47:2678–2689.

    CAS  Article  PubMed  Google Scholar 

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Correspondence to Jung Im Jung.

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Song, S.W., Jung, J.I., Lee, K.Y. et al. Malignant solitary fibrous tumor of the pleura: computed tomography-pathological correlation and comparison with computed tomography of benign solitary fibrous tumor of the pleura. Jpn J Radiol 28, 602–608 (2010). https://doi.org/10.1007/s11604-010-0484-3

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  • DOI: https://doi.org/10.1007/s11604-010-0484-3

Key words

  • Pleura
  • CT
  • Neoplasm