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Midterm results of radiofrequency ablation versus nephrectomy for T1a renal cell carcinoma

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Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

The aim of this study was to retrospectively evaluate midterm results of renal radiofrequency (RF) ablation compared to the results after nephrectomy in patients with T1a renal cell carcinoma (RCC).

Materials and methods

A total of 115 patients with a single RCC measuring ≤4 cm (T1a) were included; 51 patients underwent RF ablation, 54 patients radical nephrectomy, and 10 patients partial nephrectomy. The survival and the percent decreases in glomerular filtration rate (GFR) were compared among the three treatments.

Results

Although overall survival after RF ablation (75.0% at 5 years) was lower than those after radical and partial nephrectomy, the RCC-related survival (100% at 5 years) was comparable to those following radical nephrectomy (100% at 5 years) and partial nephrectomy (100% at 3 years). The disease-free survival (DFS) after RF ablation (98.0% at 5 years) was also comparable to those after radical nephrectomy (95.0% at 5 years) (P = 0.72) and partial nephrectomy (75.0% at 3 years) (P = 0.13). The percent decrease in the GFR at last follow-up in the RF ablation group (median 7.9%) was significantly lower than that in the radical nephrectomy group (median 29.0%) (P < 0.001) and comparable to that in the partial nephrectomy group (median 11.5%) (P = 0.73).

Conclusion

RF ablation provides RCC-related and DFS comparable to that found after nephrectomy with little loss of renal function.

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Author information

Authors and Affiliations

  1. Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, 514-8507, Japan

    Haruyuki Takaki, Koichiro Yamakado, Atsuhiro Nakatsuka, Masataka Kashima, Junji Uraki & Kan Takeda

  2. Department of Nephro-Urologic Surgery and Andrology, Mie University School of Medicine, Tsu, Japan

    Norihito Soga, Kiminobu Arima & Yoshiki Sugimura

  3. Department of Translational Medical Science, Mie University School of Medicine, Tsu, Japan

    Tomomi Yamada

Authors
  1. Haruyuki Takaki
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  2. Koichiro Yamakado
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  3. Norihito Soga
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  4. Kiminobu Arima
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  5. Atsuhiro Nakatsuka
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  6. Masataka Kashima
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  7. Junji Uraki
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  8. Tomomi Yamada
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  9. Kan Takeda
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  10. Yoshiki Sugimura
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Correspondence to Haruyuki Takaki.

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Takaki, H., Yamakado, K., Soga, N. et al. Midterm results of radiofrequency ablation versus nephrectomy for T1a renal cell carcinoma. Jpn J Radiol 28, 460–468 (2010). https://doi.org/10.1007/s11604-010-0451-z

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  • DOI: https://doi.org/10.1007/s11604-010-0451-z

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