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Pulmonary and thymic lymphoid hyperplasia in primary Sjögren’s syndrome

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Abstract

Pulmonary and thymic lymphoid hyperplasia with characteristic clinicoradiological manifestations were seen in a 71-year-old woman who was diagnosed with primary Sjögren’s syndrome. A hazy opacity 12 mm in diameter and an anterior mediastinal nodule 20 mm in diameter were incidentally detected on computed tomography. Thoracoscopic biopsy revealed lymphoid hyperplasia in the lung accompanying thymic lymphoid hyperplasia. Immunohistochemically, the pulmonary lesion was considered to be nodular lymphoid hyperplasia (NLH), not lymphoma. A previously undescribed finding in the NLH was the hazy opacity containing an air bronchiologram, not a solid nodule. This finding might suggest a common causal relation for NLH, thymic hyperplasia, and primary Sjögren’s syndrome.

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References

  1. Abbondanzo SL, Rush W, Bijwaard KE, Koss MN. Nodular lymphoid hyperplasia of the lung: a clinicopathologic study of 14 cases. Am J Surg Pathol 2000;24:587–597.

    Article  PubMed  CAS  Google Scholar 

  2. Kurumagawa T, Kobayashi H, Motoyoshi K. Potential involvement of subclinical Sjögren’s syndrome in various lung diseases. Respirology 2005;10:86–91.

    Article  PubMed  Google Scholar 

  3. Do KH, Lee JS, Seo JB, Song JW, Chung MJ, Heo JN, et al. Pulmonary parenchymal involvement of low-grade lymphoproliferativedisorders. J Comput Assist Tomogr 2005;29:825–830.

    Article  PubMed  Google Scholar 

  4. Song MK, Seol YM, Park YE, Kim YS, Lee MK, Lee CH, et al. Pulmonary nodular lymphoid hyperplasia associated with Sjögren’s syndrome. Korean J Intern Med 2007;22:192–196.

    PubMed  CAS  Google Scholar 

  5. Kobayashi H, Shimokawaji T, Kanoh S, Motoyoshi K, Aida S. IgG4-positive pulmonary disease. J Thorac Imag 2007;22:360–362.

    Article  Google Scholar 

  6. Kobayashi H, Kanoh S, Motoyoshi K, Aida S. Tracheo-broncho-bronchiolar lesions in Sjögren’s syndrome. Respirology 2008;13:159–161.

    PubMed  Google Scholar 

  7. Kobayashi H, Matsuoka R, Kitamura S, Tsunoda N, Saito K. Sjögren syndrome with multiple bullae and pulmonary nodular amyloidosis. Chest 1988;94:438–440.

    Article  PubMed  CAS  Google Scholar 

  8. Nakagawa M, Hara M, Itoh M, Shibamoto Y. Nodular thymic lymphoid follicular hyperplasia mimicking thymoma. Clin Imaging 2008;32:54–57.

    Article  PubMed  Google Scholar 

  9. Levine GD, Rosai J. Thymic hyperplasia and neoplasia: a review of current concepts. Hum Pathol 1978;9:495–515.

    Article  PubMed  CAS  Google Scholar 

  10. Kodama K, Higashiyama M, Yokouchi H, Takami K, Kuriyama K, Kusunoki Y, et al. Natural history of pure ground-glass opacity after long-term follow-up of more than 2 years. Ann Thorac Surg 2002;73:386–392.

    Article  PubMed  Google Scholar 

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Correspondence to Hideo Kobayashi.

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Kobayashi, H., Ozeki, Y. & Aida, S. Pulmonary and thymic lymphoid hyperplasia in primary Sjögren’s syndrome. Jap J Radiol 27, 107–110 (2009). https://doi.org/10.1007/s11604-008-0298-8

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  • DOI: https://doi.org/10.1007/s11604-008-0298-8

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