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Role of cardiac computed tomography in patients with suspected coronary artery disease: interaction with nuclear cardiology

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Abstract

Coronary computed tomography (CT) angiography (CTA) and myocardial perfusion single photon emission CT (SPECT, or MPS) provide complementary information on vascular structure and myocardial perfusion. In patients with coronary artery disease (CAD), the combination of both methods is helpful for disease detection and therapeutic strategy planning. This article addresses the utility of coronary CTA with current 64-row multidetector CT instruments, MPS, and the combination of these methods in the evaluation of CAD.

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References

  1. K Nieman F Cademartiri PA Lemos R Raaijmakers PM Pattynama PJ De Feyter (2002) ArticleTitleReliable noninvasive coronary angiography with fast submillimeter multislice spiral computed tomography Circulation 106 2051–4 Occurrence Handle12379572 Occurrence Handle10.1161/01.CIR.0000037222.58317.3D

    Article  PubMed  Google Scholar 

  2. JD Schuijf G Pundziute JW Jukema HJ Lamb BL van der Hoeven A de Roos et al. (2006) ArticleTitleDiagnostic accuracy of 64-slice multislice computed tomography in the noninvasive evaluation of significant coronary artery disease Am J Cardiol 98 145–8 Occurrence Handle16828582 Occurrence Handle10.1016/j.amjcard.2006.01.092

    Article  PubMed  Google Scholar 

  3. S Leschka H Alkadhi A Plass L Desbiolles J Grunenfelder B Marincek et al. (2005) ArticleTitleAccuracy of MSCT coronary angiography with 64-slice technology: first experience Eur Heart J 26 1482–7 Occurrence Handle15840624 Occurrence Handle10.1093/eurheartj/ehi261

    Article  PubMed  Google Scholar 

  4. GL Raff MJ Gallagher WW O'Neill JA Goldstein (2005) ArticleTitleDiagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography J Am Coll Cardiol 46 552–7 Occurrence Handle16053973 Occurrence Handle10.1016/j.jacc.2005.05.056

    Article  PubMed  Google Scholar 

  5. AW Leber A Knez F von Ziegler A Becker K Nikolaou S Paul et al. (2005) ArticleTitleQuantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography: a comparative study with quantitative coronary angiography and intravascular ultrasound J Am Coll Cardiol 46 147–54 Occurrence Handle15992649 Occurrence Handle10.1016/j.jacc.2005.03.071

    Article  PubMed  Google Scholar 

  6. NR Mollet F Cademartiri CA van Mieghem G Runza EP McFadden T Baks et al. (2005) ArticleTitleHigh-resolution spiral computed tomography coronary angiography in patients referred for diagnostic conventional coronary angiography Circulation 112 2318–23 Occurrence Handle16203914 Occurrence Handle10.1161/CIRCULATIONAHA.105.533471

    Article  PubMed  Google Scholar 

  7. R Hachamovitch SW Hayes JD Friedman I Cohen DS Berman (2003) ArticleTitleComparison of the short-term survival benefit associated with revascularization compared with medical therapy in patients with no prior coronary artery disease undergoing stress myocardial perfusion single photon emission computed tomography Circulation 107 2900–7 Occurrence Handle12771008 Occurrence Handle10.1161/01.CIR.0000072790.23090.41

    Article  PubMed  Google Scholar 

  8. S Achenbach F Moselewski D Ropers M Ferencik U Hoffmann B MacNeill et al. (2004) ArticleTitleDetection of calcified and noncalcified coronary atherosclerotic plaque by contrast-enhanced, submillimeter multidetector spiral computed tomography: a segment-based comparison with intravascular ultrasound Circulation 109 14–7 Occurrence Handle14691045 Occurrence Handle10.1161/01.CIR.0000111517.69230.0F

    Article  PubMed  Google Scholar 

  9. S Glagov E Weisenberg CK Zarins R Stankunavicius GJ Kolettis (1987) ArticleTitleCompensatory enlargement of human atherosclerotic coronary arteries N Engl J Med 316 1371–5 Occurrence Handle3574413 Occurrence Handle1:STN:280:DyaL2s3gtFOqsg%3D%3D Occurrence Handle10.1056/NEJM198705283162204

    Article  PubMed  CAS  Google Scholar 

  10. G Pundziute JD Schuijf JW Jukema E Boersma A de Roos EE van der Wall et al. (2007) ArticleTitlePrognostic value of multislice computed tomography coronary angiography in patients with known or suspected coronary artery disease J Am Coll Cardiol 49 62–70 Occurrence Handle17207724 Occurrence Handle10.1016/j.jacc.2006.07.070

    Article  PubMed  Google Scholar 

  11. R Wayhs A Zelinger P Raggi (2002) ArticleTitleHigh coronary artery calcium scores pose an extremely elevated risk for hard events J Am Coll Cardiol 39 225–30 Occurrence Handle11788211 Occurrence Handle10.1016/S0735-1097(01)01737-5

    Article  PubMed  Google Scholar 

  12. GT Lau LJ Ridley MC Schieb DB Brieger SB Freedman LA Wong et al. (2005) ArticleTitleCoronary artery stenoses: detection with calcium scoring, CT angiography, and both methods combined Radiology 235 415–22 Occurrence Handle15858083 Occurrence Handle10.1148/radiol.2352031813

    Article  PubMed  Google Scholar 

  13. R Hachamovitch SW Hayes JD Friedman I Cohen DS Berman (2004) ArticleTitleStress myocardial perfusion single-photon emission computed tomography is clinically effective and cost effective in risk stratification of patients with a high likelihood of coronary artery disease (CAD) but no known CAD J Am Coll Cardiol 43 200–8 Occurrence Handle14736438 Occurrence Handle10.1016/j.jacc.2003.07.043

    Article  PubMed  Google Scholar 

  14. MJ Garcia J Lessick MH Hoffmann (2006) ArticleTitleAccuracy of 16-row multidetector computed tomography for the assessment of coronary artery stenosis JAMA 296 403–11 Occurrence Handle16868298 Occurrence Handle10.1001/jama.296.4.403 Occurrence Handle1:CAS:528:DC%2BD28Xntlals74%3D

    Article  PubMed  CAS  Google Scholar 

  15. S Rispler Z Keidar E Ghersin A Roguin A Soil R Dragu et al. (2007) ArticleTitleIntegrated single-photon emission computed tomography and computed tomography coronary angiography for the assessment of hemodynamically significant coronary artery lesions J Am Coll Cardiol 49 1059–67 Occurrence Handle17349885 Occurrence Handle10.1016/j.jacc.2006.10.069

    Article  PubMed  Google Scholar 

  16. JD Schuijf W Wijns JW Jukema DE Atsma A de Roos HJ Lamb et al. (2006) ArticleTitleRelationship between noninvasive coronary angiography with multi-slice computed tomography and myocardial perfusion imaging J Am Coll Cardiol 48 2508–14 Occurrence Handle17174190 Occurrence Handle10.1016/j.jacc.2006.05.080

    Article  PubMed  Google Scholar 

  17. PW Serruys AT Ong LA van Herwerden JE Sousa A Jatene JJ Bonnier et al. (2005) ArticleTitleFive-year outcomes after coronary stenting versus bypass surgery for the treatment of multivessel disease: the final analysis of the Arterial Revascularization Therapies Study (ARTS) randomized trial J Am Coll Cardiol 46 575–81 Occurrence Handle16098418 Occurrence Handle10.1016/j.jacc.2004.12.082

    Article  PubMed  Google Scholar 

  18. EL Hannan MJ Racz G Walford RH Jones TJ Ryan E Bennett et al. (2005) ArticleTitleLong-term outcomes of coronary-artery bypass grafting versus stent implantation N Engl J Med 352 2174–83 Occurrence Handle15917382 Occurrence Handle10.1056/NEJMoa040316 Occurrence Handle1:CAS:528:DC%2BD2MXksFOmuro%3D

    Article  PubMed  CAS  Google Scholar 

  19. FQ Almeda RJ Snell (2005) ArticleTitleCoronary revascularization in multivessel disease: which is better, stents or surgery? Postgrad Med 118 11–7 Occurrence Handle16382760

    PubMed  Google Scholar 

  20. LW Klein (2006) ArticleTitleAre drug-eluting stents the preferred treatment for multivessel coronary artery disease? J Am Coll Cardiol 47 22–6 Occurrence Handle16386659 Occurrence Handle10.1016/j.jacc.2005.08.057 Occurrence Handle1:CAS:528:DC%2BD2MXhtlGmu7bP

    Article  PubMed  CAS  Google Scholar 

  21. H Sakuma Y Ichikawa S Chino T Hirano K Makino K Takeda (2006) ArticleTitleDetection of coronary artery stenosis with whole-heart coronary magnetic resonance angiography J Am Coll Cardiol 48 1946–50 Occurrence Handle17112982 Occurrence Handle10.1016/j.jacc.2006.07.055

    Article  PubMed  Google Scholar 

  22. D Maintz H Seifarth T Flohr S Kramer T Wichter W Heindel et al. (2003) ArticleTitleImproved coronary artery stent visualization and in-stent stenosis detection using 16-slice computed-tomography and dedicated image reconstruction technique Invest Radiol 38 790–5 Occurrence Handle14627897

    PubMed  Google Scholar 

  23. D Utsunomiya K Awai T Sakamoto H Hazeyama T Nishiharu J Urata et al. (2006) ArticleTitleIn vitro evaluation of metallic coronary artery stents with sub-millimeter multi-slice computed tomography using an ECG-gated cardiac phantom: relationship between in-stent visualization and stent type Cardiology 107 254–60 Occurrence Handle16953111 Occurrence Handle10.1159/000095502 Occurrence Handle1:CAS:528:DC%2BD2sXltlakur0%3D

    Article  PubMed  CAS  Google Scholar 

  24. C Probst A Kovacs C Schmitz W Schiller H Schild A Welz (2005) ArticleTitleQuantification of coronary artery stenosis with 16-slice MSCT in patients before CABG surgery: comparison to standard invasive coronary angiography Heart Surg Forum 8 E42–6 Occurrence Handle15769714 Occurrence Handle10.1532/HSF98.20041144 Occurrence Handle1:STN:280:DC%2BD2M7jslyrtg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  25. BM Tsui GT Gullberg ER Edgerton JG Ballard JR Perry WH McCartney et al. (1989) ArticleTitleCorrection of nonuniform attenuation in cardiac SPECT imaging J Nucl Med 30 497–507 Occurrence Handle2786944 Occurrence Handle1:STN:280:DyaL1M3ptlaqtw%3D%3D

    PubMed  CAS  Google Scholar 

  26. D Utsunomiya S Tomiguchi S Shiraishi K Yamada T Honda K Kawanaka et al. (2005) ArticleTitleInitial experience with X-ray CT based attenuation correction in myocardial perfusion SPECT imaging using a combined SPECT/CT system Ann Nucl Med 19 485–9 Occurrence Handle16248385

    PubMed  Google Scholar 

  27. S Borges-Neto LK Shaw (1999) ArticleTitleThe added value of simultaneous myocardial perfusion and left ventricular function Curr Opin Cardiol 14 460–3 Occurrence Handle10579060 Occurrence Handle10.1097/00001573-199911000-00002 Occurrence Handle1:STN:280:DC%2BD3c%2Fks1ShsA%3D%3D

    Article  PubMed  CAS  Google Scholar 

  28. PF Hoilund-Carlsen A Johansen HW Christensen W Vach M Moldrup P Bartram et al. (2006) ArticleTitlePotential impact of myocardial perfusion scintigraphy as gatekeeper for invasive examination and treatment in patients with stable angina pectoris: observational study without post-test referral bias Eur Heart J 27 29–34 Occurrence Handle16183689 Occurrence Handle10.1093/eurheartj/ehi503

    Article  PubMed  Google Scholar 

  29. M Sahin S Karakelleoglu N Alp S Atesal H Senocak (1994) ArticleTitleDiagnostic value of dobutamine stress echocardiography in coronary artery disease Thorac Cardiovasc Surg 42 285–9 Occurrence Handle7863491 Occurrence Handle1:STN:280:DyaK2M7mslKmsQ%3D%3D Occurrence Handle10.1055/s-2007-1016506

    Article  PubMed  CAS  Google Scholar 

  30. H Sakuma N Suzawa Y Ichikawa K Makino T Hirano K Kitagawa et al. (2005) ArticleTitleDiagnostic accuracy of stress first-pass contrast-enhanced myocardial perfusion MRI compared with stress myocardial perfusion scintigraphy AJR Am J Roentgenol 185 95–102 Occurrence Handle15972407

    PubMed  Google Scholar 

  31. M Hamon GG Biondi-Zoccai P Malagutti P Agostoni R Morello M Valgimigli (2006) ArticleTitleDiagnostic performance of multislice spiral computed tomography of coronary arteries as compared with conventional invasive coronary angiography: a meta-analysis J Am Coll Cardiol 48 1896–910 Occurrence Handle17084268 Occurrence Handle10.1016/j.jacc.2006.08.028

    Article  PubMed  Google Scholar 

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Correspondence to Daisuke Utsunomiya.

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Utsunomiya, D., Tomiguchi, S. & Yamashita, Y. Role of cardiac computed tomography in patients with suspected coronary artery disease: interaction with nuclear cardiology. Radiat Med 25, 493–501 (2007). https://doi.org/10.1007/s11604-007-0178-7

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  • DOI: https://doi.org/10.1007/s11604-007-0178-7

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