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Experimental verification of the utility of positron emitter nuclei generated by photonuclear reactions for X-ray beam monitoring in a phantom

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Abstract

Purpose

The utility of positron emitter nuclei generated by photonuclear reactions was verified for X-ray beam monitoring in a phantom.

Materials and methods

Positron emission tomography-computed tomography (PET-CT) images of a gelatinous water phantom (H2O target) and a polyethylene phantom (CH2 target) were acquired 5 min after delivering a dose of 17 Gy with an X-ray beam energy of 21 MV. Reconstructed PET images and the calculated half-life showed that the positron emitters of 15O (half-life 122.2 s) in the H2O target and 11C (half-life 20.4 min) in the CH2 target were generated by photonuclear reactions.

Results

A comparison was made between measured activity and dose distributions for each target. The measured times of annihilation gamma rays from the positron emitter nucleus were 10 and 30 min for the 15O nucleus in the H2O target and the 11C nucleus in the CH2 target, respectively. The activity distributions of the 15O and 11C positron emitter nuclei were similar to the measured dose distributions for both depth and lateral directions except for dose buildup and collimator edge regions. It was confirmed that no activity was detected at an X-ray energy of 14 MV, which was far below the energy threshold for both photonuclear reactions.

Conclusion

It was estimated that the PET-CT image acquired from the activity of the 15O and 11C positron emitter nuclei might provide the area of X-ray beam irradiation in a phantom.

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Authors and Affiliations

  1. Particle Therapy Division, Research Center for Innovative Oncology, National Cancer Center, 6-5-1 Kashiwano-ha, Kashiwa, 277-8577, Japan

    Teiji Nishio & Takashi Ogino

  2. Department of Radiology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

    Teiji Nishio

  3. Department of Energy Sciences, Tokyo Institute of Technology, Yokohama, Japan

    Taku Inaniwa

  4. Functional Imaging Division, Research Center for Inovative Oncology, National Cancer Center, Kashiwa, Japan

    Kazumasa Inoue

  5. Department of Nuclear Engineering and Management, Graduate School of Engineering, University of Tokyo, Tokyo, Japan

    Teiji Nishio & Aya Miyatake

  6. Department of Radiology, Faculty of Medicine, University of Tokyo, Tokyo, Japan

    Keiichi Nakagawa

  7. Elekta K.K., Kobe, Japan

    Kiyoshi Yoda

Authors
  1. Teiji Nishio
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  2. Taku Inaniwa
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  3. Kazumasa Inoue
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  4. Aya Miyatake
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  5. Keiichi Nakagawa
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  6. Kiyoshi Yoda
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  7. Takashi Ogino
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Corresponding author

Correspondence to Teiji Nishio.

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Nishio, T., Inaniwa, T., Inoue, K. et al. Experimental verification of the utility of positron emitter nuclei generated by photonuclear reactions for X-ray beam monitoring in a phantom. Radiat Med 25, 516–522 (2007). https://doi.org/10.1007/s11604-007-0177-8

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  • DOI: https://doi.org/10.1007/s11604-007-0177-8

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