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Functional neuroimaging in Alzheimer's disease

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References

  1. S Minoshima KL Berger KS Lee MA Mintun (1992) ArticleTitleAn automated method for rotational correction and centering of three-dimensional functional brain images J Nucl Med 33 1579–85 Occurrence Handle1634959 Occurrence Handle1:STN:280:By2A2c7hvFQ%3D

    PubMed  CAS  Google Scholar 

  2. S Minoshima RA Koeppe MA Mintun et al. (1993) ArticleTitleAutomated detection of the intercommissural line for stereotactic localization of functional brain images J Nucl Med 34 322–9 Occurrence Handle8429356 Occurrence Handle1:STN:280:ByyC2MrntF0%3D

    PubMed  CAS  Google Scholar 

  3. S Minoshima RA Koeppe KA Frey DE Kuhl (1993) ArticleTitleAnatomical standardization: linear scaling and nonlinear warping of functional brain images J Nucl Med 35 1528–37

    Google Scholar 

  4. H Matsuda S Mizumura T Soma N Takemura (2004) ArticleTitleConversion of brain SPECT images between different collimators and reconstruction processes for analysis using statistical parametric mapping Nucl Med Commun 25 67–74 Occurrence Handle15061267 Occurrence Handle10.1097/00006231-200401000-00010 Occurrence Handle1:STN:280:DC%2BD2c7mslerug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  5. H Kanetaka H Matsuda T Asada et al. (2004) ArticleTitleEffects of partial volume correction on discrimination between very early Alzheimer's dementia and controls using brain perfusion SPECT Eur J Nucl Med Mol Imaging 31 975–80 Occurrence Handle14991240 Occurrence Handle10.1007/s00259-004-1491-3

    Article  PubMed  Google Scholar 

  6. CD Frith KJ Friston J Ashburner et al. (1997) Principles and methods RSJ Frackowiak KJ Friston CD Frith RJ Dolan JC Mazziotta (Eds) Human Brain Function Academic San Diego 3–159

    Google Scholar 

  7. G Emilinen K Beyreuther CL Masters JM Maloteaux (2000) ArticleTitleProspects for pharmacological intervention in Alzheimer disease Arch Neurol 57 454–9 Occurrence Handle10.1001/archneur.57.4.454

    Article  Google Scholar 

  8. K Ishii F Willoch S Minoshima et al. (2001) ArticleTitleStatistical brain mapping of 18F-FDG PET in Alzheimer's disease: validation of anatomic standardization for atrophied brains J Nucl Med 42 548–57 Occurrence Handle11337540 Occurrence Handle1:STN:280:DC%2BD3MvkvVCqtg%3D%3D

    PubMed  CAS  Google Scholar 

  9. RC Petersen R Doody A Kurz et al. (2001) ArticleTitleCurrent concepts in mild cognitive impairment Arch Neurol 58 1985–92 Occurrence Handle11735772 Occurrence Handle10.1001/archneur.58.12.1985 Occurrence Handle1:STN:280:DC%2BD38%2FivVyrsw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  10. S Minoshima NL Foster DE Kuhl (1994) ArticleTitlePosterior cingulate cortex in Alzheimer's disease Lancet 344 895 Occurrence Handle7916431 Occurrence Handle10.1016/S0140-6736(94)92871-1 Occurrence Handle1:STN:280:ByuA2snlslE%3D

    Article  PubMed  CAS  Google Scholar 

  11. S Minoshima B Giordani S Berent et al. (1997) ArticleTitleMetabolic reduction in the psoterior cingulate cortex in very early Alzheimer's disease Ann Neurol 42 85–94 Occurrence Handle9225689 Occurrence Handle10.1002/ana.410420114 Occurrence Handle1:STN:280:ByiA28bitVU%3D

    Article  PubMed  CAS  Google Scholar 

  12. D Kogure H Matsuda T Ohnishi et al. (2000) ArticleTitleLongitudinal evaluation of early Alzheimer's disease using brain perfusion SPECT J Nucl Med 41 1155–62 Occurrence Handle10914904 Occurrence Handle1:STN:280:DC%2BD3czpslemsA%3D%3D

    PubMed  CAS  Google Scholar 

  13. N Okamura H Arai M Maruyama et al. (2002) ArticleTitleCombined Analysis of CSF tau levels and [123I]iodoamphetamine SPECT in mild cognitive impairment: implications for a novel predictor of Alzheimer's disease Am J Psychiatry 159 474–6 Occurrence Handle11870015 Occurrence Handle10.1176/appi.ajp.159.3.474

    Article  PubMed  Google Scholar 

  14. V Ibanez P Pietrini GE Alexandar et al. (1998) ArticleTitleRegional glucose metabolic abnormalities are not the result of atrophy in Alzheimer's disease Neurology 50 1585–93 Occurrence Handle9633698 Occurrence Handle1:STN:280:DyaK1c3psFCmtw%3D%3D

    PubMed  CAS  Google Scholar 

  15. E Imabayashi H Matsuda T Asada et al. (2004) ArticleTitleSuperiority of 3-dimensional stereotactic surface projection analysis over visual inspection in discrimination of patients with very early Alzheimer's disease from controls using brain perfusion SPECT J Nucl Med 45 1450–7 Occurrence Handle15347711

    PubMed  Google Scholar 

  16. GW Small JC Mazziotta MT Collins et al. (1995) ArticleTitleApolipoprotein E type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease JAMA 273 942–7 Occurrence Handle7884953 Occurrence Handle10.1001/jama.273.12.942 Occurrence Handle1:CAS:528:DyaK2MXkvF2htrc%3D

    Article  PubMed  CAS  Google Scholar 

  17. GW Small LM Ercoli DH Silverman et al. (2000) ArticleTitleCerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease Proc Natl Acad Sci USA 97 6037–42 Occurrence Handle10811879 Occurrence Handle10.1073/pnas.090106797 Occurrence Handle1:CAS:528:DC%2BD3cXjvFarsbs%3D

    Article  PubMed  CAS  Google Scholar 

  18. JC Mazziota ME Phelps (1986) Principles and applications for the brain and heat ME Phelps JC Mazziotal H Schelbert (Eds) Positron Emission Tomography and Autoradiography Raven New York 493–579

    Google Scholar 

  19. T Gomez-Isla TL Price DW McKeel et al. (1996) ArticleTitleProfound loss of layer II enthorhinal cortex neurons occurs in very mild Alzheimer's disease J Neuroscience 16 4491–500 Occurrence Handle1:CAS:528:DyaK28XktlamsLs%3D

    CAS  Google Scholar 

  20. K Meguro X Blaizot Y Kondoh C Le Mestric JC Baron C Chavoix (1999) ArticleTitleNeocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET: implications for Alzheimer's disease Brain 122 1519–31 Occurrence Handle10430835 Occurrence Handle10.1093/brain/122.8.1519

    Article  PubMed  Google Scholar 

  21. S Minoshima DJ Cross NL Foster TR Henry DE Kuhl (1999) ArticleTitleDiscordance between traditional pathologic and energy metabolic changes in very early Alzheimer's disease: pathophysiological implications Ann NY Acad Sci 893 350–2 Occurrence Handle10672264 Occurrence Handle10.1111/j.1749-6632.1999.tb07852.x Occurrence Handle1:CAS:528:DC%2BD3cXms1GksQ%3D%3D

    Article  PubMed  CAS  Google Scholar 

  22. L Mosconi A Pupi MT De Cristofaro M Fayyaz S Sorbi K Herholz (2004) ArticleTitleFunctional interactions of the entorhinal cortex: an 18F-FDG PET study on normal aging and Alzheimer's disease J Nucl Med 45 382–92 Occurrence Handle15001677

    PubMed  Google Scholar 

  23. B Desgranges JC Baron V de la Sayette et al. (1998) ArticleTitleThe neural substrates of memory systems impairment in Alzheimer's disease: a PET study of resting brain glucose utilization Brain 121 611–31 Occurrence Handle9577389 Occurrence Handle10.1093/brain/121.4.611

    Article  PubMed  Google Scholar 

  24. PC Fletcher CD Frith PM Grasby T Shallice RSJ Frackwiak RJ Dolan (1995) ArticleTitleBrain system for encoding and retrieval of auditory-verbal memory Brain 118 401–16 Occurrence Handle7735882

    PubMed  Google Scholar 

  25. P Rudge EK Warrington (1991) ArticleTitleSelective impairment of memory and visual perception in splenial tumours Brain 114 349–60 Occurrence Handle2004246

    PubMed  Google Scholar 

  26. E Valenstein D Bowers M Verfaellie KM Heilman A Day RT Watson (1987) ArticleTitleRetrosplenial amnesia Brain 110 1631–46 Occurrence Handle3427404

    PubMed  Google Scholar 

  27. JW Papez (1937) ArticleTitleA proposed mechanism of emotion Arch Neurol Psychiatry 38 725–43

    Google Scholar 

  28. AD Wagner BJ Shannon I Kahn RL Buckner (2005) ArticleTitleParietal lobe contributions to episodic memory retrieval Trends Cogn Sci 9 445–53 Occurrence Handle16054861 Occurrence Handle10.1016/j.tics.2005.07.001

    Article  PubMed  Google Scholar 

  29. G Chetelat B Desgranges V de la Sayette F Viader F Eustache JC Baron (2003) ArticleTitleMild cognitive impairment: can FDG-PET predict who is to rapidly convert to Alzheimer's disease? Neurology 60 1374–7 Occurrence Handle12707450 Occurrence Handle1:STN:280:DC%2BD3s7ovVKgug%3D%3D

    PubMed  CAS  Google Scholar 

  30. L Mosconi D Perani S Sorbi et al. (2004) ArticleTitleMCI conversion to dementia and the APOE genotype: a prediction study with FDG-PET Neurology 63 2332–40 Occurrence Handle15623696 Occurrence Handle1:STN:280:DC%2BD2cnkslWitw%3D%3D

    PubMed  CAS  Google Scholar 

  31. C Huang LO Wahlund L Svensson B Winblad P Julin (2002) ArticleTitleCingulate cortex hypoperfusion predicts Alzheimer's disease in mild cognitive impairment BMC Neurol 2 9 Occurrence Handle12227833 Occurrence Handle10.1186/1471-2377-2-9

    Article  PubMed  Google Scholar 

  32. A Drzezga N Lautenschlager H Siebner et al. (2003) ArticleTitleCerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer's disease: a PET follow-up study Eur J Nucl Med Mol Imaging 30 1104–13 Occurrence Handle12764551 Occurrence Handle10.1007/s00259-003-1194-1

    Article  PubMed  Google Scholar 

  33. Hirao K, Ohnishi T, Hirata Y, et al. The prediction of rapid conversion to Alzheimer's disease in mild cognitive impairment using regional cerebral blood flow SPECT. Neuroimage (in press).

  34. H Matsuda T Ohnishi T Asada et al. (2003) ArticleTitleCorrection for partial-volume effects on brain perfusion SPECT in healthy men J Nucl Med 44 1243–52 Occurrence Handle12902414

    PubMed  Google Scholar 

  35. D Yanase I Matsunari K Yajima et al. (2005) ArticleTitleBrain FDG PET study of normal aging in Japanese: effect of atrophy correction Eur J Nucl Med Mol Imaging 32 794–805 Occurrence Handle15759148 Occurrence Handle10.1007/s00259-005-1767-2

    Article  PubMed  Google Scholar 

  36. H Matsuda H Kanetaka T Ohnishi et al. (2002) ArticleTitleBrain SPECT abnormalities in Alzheimer's disease before and after atrophy correction Eur J Nucl Med Mol Imaging 29 1502–5 Occurrence Handle12397471 Occurrence Handle10.1007/s00259-002-0930-2 Occurrence Handle1:CAS:528:DC%2BD38XotV2it7s%3D

    Article  PubMed  CAS  Google Scholar 

  37. JC Baron G Chetelat B Desganges et al. (2001) ArticleTitleIn vivo mapping of gray matter loss with voxel-based morphometry in mild Alzheimer's disease Neuroimage 14 298–309 Occurrence Handle11467904 Occurrence Handle10.1006/nimg.2001.0848 Occurrence Handle1:STN:280:DC%2BD3MvitVGmug%3D%3D

    Article  PubMed  CAS  Google Scholar 

  38. T Ohnishi H Hoshi S Nagamachi et al. (1995) ArticleTitleHigh-resolution SPECT to assess hippocampal perfusion in neuropsychiatric diseases J Nucl Med 36 1163–9 Occurrence Handle7790939 Occurrence Handle1:STN:280:ByqA3M7gt1I%3D

    PubMed  CAS  Google Scholar 

  39. K Ishii M Sasaki S Yamaji S Sakamoto H Kitagaki E Mori (1998) ArticleTitleParadoxical hippocampus perfusion in mild-to-moderate Alzheimer's disease J Nucl Med 39 293–8 Occurrence Handle9476938 Occurrence Handle1:STN:280:DyaK1c7jsFyjtw%3D%3D

    PubMed  CAS  Google Scholar 

  40. JW Geddes DT Monaghan CW Cotman IT Lott RC Kim HC Chui (1985) ArticleTitlePlasticity of hippocampal circuitry in Alzheimer's disease Science 230 1179–81 Occurrence Handle4071042 Occurrence Handle1:STN:280:DyaL28%2FntVWqsQ%3D%3D

    PubMed  CAS  Google Scholar 

  41. S de Santi MJ De Leon H Rusinek et al. (2001) ArticleTitleHippocampal formation glucose metabolism and volume losses in MCI and AD Neurobiol Aging 22 529–39 Occurrence Handle11445252 Occurrence Handle10.1016/S0197-4580(01)00230-5 Occurrence Handle1:CAS:528:DC%2BD3MXltVCqtro%3D

    Article  PubMed  CAS  Google Scholar 

  42. R Barber C Ballard IG McKeith A Gholkar JT O’Brien (2000) ArticleTitleMRI volumetric study of dementia with Lewy bodies: a comparison with AD and vascular dementia Neurology 54 1304–9 Occurrence Handle10746602 Occurrence Handle1:STN:280:DC%2BD3cvgs1ClsQ%3D%3D

    PubMed  CAS  Google Scholar 

  43. SJ Colloby JD Fenwick ED Williams et al. (2002) ArticleTitleA comparison of 99mTc-HMPAO SPECT changes in dementia with Lewy bodies and Alzheimer's disease using statistical parametric mapping Eur J Nucl Med Mol Imaging 29 615–22 Occurrence Handle11976799 Occurrence Handle10.1007/s00259-002-0778-5

    Article  PubMed  Google Scholar 

  44. SJ Colloby JT O’Brien JD Fenwick et al. (2004) ArticleTitleThe application of statistical parametric mapping to 123I-FP-CIT SPECT in dementia with Lewy bodies, Alzheimer's disease and Parkinson's disease Neuroimage 23 956–66 Occurrence Handle15528096 Occurrence Handle10.1016/j.neuroimage.2004.06.045

    Article  PubMed  Google Scholar 

  45. S Minoshima NL Foster AA Sima KA Frey RL Albin DE Kuhl (2001) ArticleTitleAlzheimer's disease versus dementia with Lewy bodies: cerebral metabolic distinction with autopsy confirmation Ann Neurol 50 358–65 Occurrence Handle11558792 Occurrence Handle10.1002/ana.1133 Occurrence Handle1:STN:280:DC%2BD3MrhtFCntg%3D%3D

    Article  PubMed  CAS  Google Scholar 

  46. J Pasquier BF Michel I Brenot-Rossi N Hassan-Sebbag R Sauvan JL Gastaut (2002) ArticleTitleValue of 99mTc-ECD SPECT for the diagnosis of dementia with Lewy bodies Eur J Nucl Med Mol Imaging 29 1342–8 Occurrence Handle12271417 Occurrence Handle10.1007/s00259-002-0919-x Occurrence Handle1:CAS:528:DC%2BD38Xnt1Gnsrs%3D

    Article  PubMed  CAS  Google Scholar 

  47. K Ishii K Hosaka T Mori E Mori (2004) ArticleTitleComparison of FDG-PET and IMP-SPECT in patients with dementia with Lewy bodies Ann Nucl Med 18 447–51 Occurrence Handle15462408 Occurrence Handle10.1007/BF02984489

    Article  PubMed  Google Scholar 

  48. PT Francis AM Palmar M Snape GK Wlcock (1999) ArticleTitleThe cholinergic hypothesis of Alzheimer's disease: a review of progress J Neurol Neurosurg Psychiatry 66 137–47 Occurrence Handle10071091 Occurrence Handle1:STN:280:DyaK1M7mvVKnuw%3D%3D Occurrence Handle10.1136/jnnp.66.2.137

    Article  PubMed  CAS  Google Scholar 

  49. SL Rogers MR Farlow RS Doody et al. (1998) ArticleTitleA 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease Neurology 50 136–45 Occurrence Handle9443470 Occurrence Handle1:CAS:528:DyaK1cXotVKjsA%3D%3D

    PubMed  CAS  Google Scholar 

  50. SL Rogers RS Doody R Mohs et al. (1998) ArticleTitleDonepezil improves cognition and global function in Alzheimer disease Arch Intern Med 158 1021–31 Occurrence Handle9588436 Occurrence Handle10.1001/archinte.158.9.1021 Occurrence Handle1:CAS:528:DyaK1cXjt1yhsL0%3D

    Article  PubMed  CAS  Google Scholar 

  51. MS Mega ID Dinov L Lee et al. (2000) ArticleTitleOribital and dorsolateral frontal perfusion defect associated with behavioral response to cholinesterase inhibitor therapy in Alzheimer's disease J Neuropsychiatry Clin Neurosci 12 209–18 Occurrence Handle11001599 Occurrence Handle1:CAS:528:DC%2BD3MXitlKgtbw%3D

    PubMed  CAS  Google Scholar 

  52. RT Staff HG Gemmelll MF Shanks AD Murray A Venneri (2000) ArticleTitleChanges in the rCBF images of patients with Alzheimer's disease receiving Donepezil therapy Nucl Med Commun 21 37–41 Occurrence Handle10717900 Occurrence Handle10.1097/00006231-200001000-00007 Occurrence Handle1:CAS:528:DC%2BD3cXhtlGmsrw%3D

    Article  PubMed  CAS  Google Scholar 

  53. F Nobili M Koulibaly P Vitali et al. (2002) ArticleTitleBrain perfusion follow-up in Alzheimer's patients during treatment with acetylcholinesterase inhibitors J Nucl Med 43 983–90 Occurrence Handle12163621 Occurrence Handle1:CAS:528:DC%2BD38Xms1Shurc%3D

    PubMed  CAS  Google Scholar 

  54. R Ceravolo D Volterrani G Tognoni et al. (2004) ArticleTitleCerebral perfusional effects of cholinesterase inhibitors in Alzheimer disease Clin Neuropharmacol 27 166–70 Occurrence Handle15319702 Occurrence Handle10.1097/01.wnf.0000138636.42121.45 Occurrence Handle1:CAS:528:DC%2BD2cXmvVars78%3D

    Article  PubMed  CAS  Google Scholar 

  55. S Nakano T Asada H Matsuda M Uno M Takasaki (2001) ArticleTitleDonepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease J Nucl Med 42 1441–5 Occurrence Handle11585854 Occurrence Handle1:CAS:528:DC%2BD38XksVSmtbc%3D

    PubMed  CAS  Google Scholar 

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Correspondence to Hiroshi Matsuda.

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This work was presented as an educational lecture at the 64th JRS meeting (April 2005) in Yokohama.

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Matsuda, H. Functional neuroimaging in Alzheimer's disease. Radiat Med 24, 302–308 (2006). https://doi.org/10.1007/s11604-006-2408-9

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