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Radiation Medicine

, Volume 25, Issue 3, pp 106–112 | Cite as

Enhancement of the liver on dynamic MDCT: investigation among three groups consisting of noncirrhotic patients and cirrhotic patients with and without a large portosystemic shunt

  • Kouichirou NaruoEmail author
  • Mitsuhiro Tozaki
  • Yasushi Fukuda
  • Kunihiko Fukuda
ORIGINAL ARTICLE
  • 39 Downloads

Abstract

Purpose

The aim of this study was to determine any difference in hepatic enhancement values on dynamic multidetector row computed tomagraphy (MDCT) among three groups: noncirrhotic patients and cirrhotic patients with and without a large portosystemic shunt.

Materials and methods

A group of 20 noncirrhotic patients (group A), 43 cirrhotic patients without a large shunt (group B), and 20 cirrhotic patients with a large shunt (group C) underwent dynamic MDCT of the liver using a standard concentration (300 mg I/ml) and volume (100 ml) of contrast material. The attenuation values of the liver were measured during arterial, portal, and late phases.

Results

The hepatic enhancement value during the portal phase was significantly higher in group A (56.2 ± 13.7 HU) than in the other two groups (group B 39.8 ± 11.9 HU, group C 41.3 ± 8.3 HU) (P < 0.01). No significant difference was present between group B and group C. The regression line of the scattergram, which shows the relation between the hepatic enhancement value during the portal phase and the iodine dose per the patients' body weight was more gently sloping in group C than in the other two groups.

Conclusion

In cirrhotic patients without a large shunt, injection of a larger amount of total iodine is necessary to optimize hypovascular tumor visualization. However, in cirrhotic patients with a large shunt, further investigation is needed concerning the effectiveness of administering a larger amount of total iodine.

Key words

MDCT Enhancement of the liver Cirrhotic liver Portosystemic shunt 

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References

  1. 1.
    Vignaux, O, Legmann, P, Coste, J, Hoeffel, C, Bonnin, A 1999Cirrhotic liver enhancement on dual-phase helical CT: comparison with non cirrhotic liver in 146 patientsAJR Am J Roentgenol17311937PubMedGoogle Scholar
  2. 2.
    Takayasu, K, Furukawa, H, Wakao, F, Muramatsu, Y, Abe, H, Terauchi, T,  et al. 1995CT diagnosis of early hepatocellular carcinoma: sensitivity, findings and CT-pathologic correlationAJR Am J Roentogenol16488590Google Scholar
  3. 3.
    Berland, LL, Lee, JY 1988Comparison of contrast media injection rates and volumes for hepatic dynamic incremental computed tomographyInvest Radiol2391822PubMedCrossRefGoogle Scholar
  4. 4.
    Heiken, JP, Brink, JA, McClennan, BL, Sagel, SS, Crowe, TM, Gaines, MV 1995Dynamic incremental CT: effect of volume and concentration of contrast material and patient weight on hepatic enhancementRadiology1953537PubMedGoogle Scholar
  5. 5.
    Awai, K, Takada, K, Ohnishi, H, Hori, S 2002Aortic and hepatic enhancement and tumor- to- liver contrast: analysis of the effect of different concentration contrast material at multidetector row helical CTRadiology22475763PubMedCrossRefGoogle Scholar
  6. 6.
    Furuta, A, Ito, K, Fujita, T, Koike, S, Shimizu, A, Matsunaga, N 2004Hepatic enhancement in multiphasic contrast-enhanced MDCT: comparison of high- and low-iodine-concentration contrast medium in same patients with chronic liver diseaseAJR Am J Roentgenol18315762PubMedGoogle Scholar
  7. 7.
    Tozaki, M, Naruo, K, Fukuda, K 2005Dynamic contrast-enhanced MDCT of the liver: analysis of the effect of different iodine concentration with the same total iodine dose in the same chronic liver disease patientsRadiat Med235338PubMedGoogle Scholar
  8. 8.
    Ogasawara, H, Fujisawa, K, Mase, Y, Mizorogi, F, Tsuchiya, T, Ohishi, H,  et al. 1986Dynamic computed tomography based on hepatic hemodynamics: A study of hepatic hemodynamics in chronic liver diseasesKanzo277818Google Scholar
  9. 9.
    Ohnishi, K 1987Hemodynamics of liver cirrhosisRinshoi13302Google Scholar
  10. 10.
    Ternberg, JL, Butcher, HR,Jr 1965Blood-flow relation between hepatic artery and portal veinScience15010301PubMedCrossRefGoogle Scholar
  11. 11.
    Lautt, WW, Legare, DJ, Ezzat, WR 1990Quantitation of the hepatic arterial buffer response to graded changes in portal blood flowGastroenterology9810248PubMedGoogle Scholar
  12. 12.
    Miles, KA, Hayball, MP, Dixon, AK 1993Functional images of hepatic perfusion obtained with dynamic CTRadiology18840511PubMedGoogle Scholar
  13. 13.
    Moriyasu, F, Nishida, O, Ban, N, Nakamura, T, Miura, K, Sakai, M,  et al. 1986Measurement of portal vascular resistance in patients with portal hypertensionGastroenterology907107PubMedGoogle Scholar

Copyright information

© Japan Radiological Society 2007

Authors and Affiliations

  • Kouichirou Naruo
    • 1
    Email author
  • Mitsuhiro Tozaki
    • 2
  • Yasushi Fukuda
    • 3
  • Kunihiko Fukuda
    • 4
  1. 1.Department of RadiologyTokyo Jikei Medical College, 3rd HospitalKomaeJapan
  2. 2.Division of Diagnostic Imaging, Breast CenterKameda Medical CenterKamogawaJapan
  3. 3.Department of RadiologyTokyu HospitalTokyoJapan
  4. 4.Department of RadiologyThe Jikei University School of MedicineKomaeJapan

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