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Radiation Medicine

, Volume 25, Issue 3, pp 94–105 | Cite as

Evaluation of tumor blood flow in musculoskeletal lesions: dynamic contrast-enhanced MR imaging and its possibility when monitoring the response to preoperative chemotherapy—work in progress

  • Makoto KajiharaEmail author
  • Yoshifumi Sugawara
  • Kenshi Sakayama
  • Keiichi Kikuchi
  • Teruhito Mochizuki
  • Kenya Murase
ORIGINAL ARTICLE

Abstract

Purpose

The objective of this study was to calculate tumor blood flow (TBF) in musculoskeletal lesions and to evaluate the usefulness of this parameter in differentiating malignant from benign lesions and monitoring the treatment response to preoperative chemotherapy.

Materials and methods

Altogether, 33 patients with musculoskeletal lesions underwent a total of 50 dynamic magnetic resonance imaging (MRI) examinations, including 28 on 9 patients undergoing preoperative chemotherapy. TBF was calculated using deconvolution analysis. Steepest slope (SS) was determined from the time–intensity curve during the first pass of contrast medium.

Results

TBF ranged from 2.7 to 178.6 mL/100 mL/min in benign lesions and from 15.4 to 296.3 mL/100 mL/min in malignant lesions. SS ranged from 0.5%/s to 31.8%/s for benign lesions and from 3.1%/s to 64.8%/sec for malignant lesions. TBF and SS did not differ significantly between benign and malignant lesions. Among the nine patients who underwent preoperative chemotherapy, TBF after chemotherapy was lower in good responders (11.7, 11.0, 7.9 mL/100 mL/min) (n = 3, tumor necrosis ≥90%) than in poor responders (23.4–141.5 mL/100 mL/min) (n = 6, tumor necrosis <90%).

Conclusion

TBF and SS cannot reliably differentiate malignant from benign lesions. However, they have potential utility in evaluating the preoperative treatment response in patients with malignant musculoskeletal tumors.

Key words

Tumor blood flow Musculoskeletal tumor Dynamic contrast-enhanced MR imaging Preoperative chemotherapy 

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Copyright information

© Japan Radiological Society 2007

Authors and Affiliations

  • Makoto Kajihara
    • 1
    Email author
  • Yoshifumi Sugawara
    • 1
  • Kenshi Sakayama
    • 2
  • Keiichi Kikuchi
    • 1
  • Teruhito Mochizuki
    • 1
  • Kenya Murase
    • 3
  1. 1.Department of RadiologyEhime University School of MedicineToonJapan
  2. 2.Department of Orthopedic SurgeryEhime University School of MedicineToonJapan
  3. 3.Department of Medical Engineering, Division of Allied Health ScienceOsaka University Medical SchoolSuitaJapan

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