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Cardiac imaging using 256-detector row four-dimensional CT: preliminary clinical report



Along with the increase of detector rows on the z-axis and a faster gantry rotation speed, the spatial and temporal resolutions of the multislice computed tomography (CT) have been improved for noninvasive coronary artery imaging. We investigated the feasibility of the second specification prototype 256-detector row four-dimensional CT for assessing coronary artery and cardiac function.

Materials and methods

The subjects were five patients with coronary artery disease. Contrast medium (40–60 ml) was intravenously administered at the rate of 3–4 ml/s. The patient's whole heart was scanned for 1.5 s to cover at least one cardiac cycle during breathholding without electrocardiographic gating. Parameters used were 0.5 mm slice thickness, 0.5 s/rotation, 120 Kv, and 350 mA, with a half-scan reconstruction algorithm (temporal resolution 250 ms). Twenty-six transaxial datasets were reconstructed at intervals of 50 ms.


The assessability of the coronary arteries in AHA segments 1, 2, 3, 5, 6, 7, 9, and 11 was visually evaluated, resulting in 29 of 32 (90.9%) segments being assessable. Functional assessment was also performed using animated movies without banding artifacts in all cases.


The 256-detector row four-dimensional CT can assess the coronary artery and cardiac function using data during 1.5 s without banding artifacts.

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  1. K Nieman M Oudkerk BJ Rensing P van Ooijen A Munne RJ van Geuns et al. (2001) ArticleTitleCoronary angiography with multi-slice computed tomography Lancet 357 599–603 Occurrence Handle11558487 Occurrence Handle10.1016/S0140-6736(00)04058-7 Occurrence Handle1:STN:280:DC%2BD3MrhtV2mtw%3D%3D

    Article  PubMed  CAS  Google Scholar 

  2. Y Sato N Matsumoto M Kato F Inoue T Horie J Kusama et al. (2003) ArticleTitleNoninvasive assessment of coronary artery disease by multislice spiral computed tomography using a new retrospectively ECG-gated image reconstruction technique Circ J 67 401–5 Occurrence Handle12736477 Occurrence Handle10.1253/circj.67.401

    Article  PubMed  Google Scholar 

  3. A Kuettner T Trabold S Schroeder A Feyer T Beck A Brueckner et al. (2004) ArticleTitleNoninvasive detection of coronary lesions using 16-detector multislice spiral computed tomography technology: initial clinical results J Am Coll Cardiol 44 1238–40

    Google Scholar 

  4. NR Mollet F Cademartiri K Nieman F Saia PA Lemos EP McFadden et al. (2004) ArticleTitleMultislice spiral computed tomography coronary angiography in patients with stable angina pectoris J Am Coll Cardiol 43 2265–70 Occurrence Handle15193691 Occurrence Handle10.1016/j.jacc.2004.03.032

    Article  PubMed  Google Scholar 

  5. AW Leber A Knez F von Ziegler A Becker K Nikolaou S Paul et al. (2005) ArticleTitleQuantification of obstructive and nonobstructive coronary lesions by 64-slice computed tomography: a comparative study with quantitative coronary angiography and intravascular ultrasound J Am Coll Cardiol 46 147–54 Occurrence Handle15992649 Occurrence Handle10.1016/j.jacc.2005.03.071

    Article  PubMed  Google Scholar 

  6. GL Raff MJ Gallagher WW O'Neill JA Goldstein (2005) ArticleTitleDiagnostic accuracy of noninvasive coronary angiography using 64-slice spiral computed tomography J Am Coll Cardiol 46 552–7 Occurrence Handle16053973 Occurrence Handle10.1016/j.jacc.2005.05.056

    Article  PubMed  Google Scholar 

  7. T Mochizuki K Murase H Higashino H Higashino Y Koyama S Azemoto et al. (2000) ArticleTitleTwo- and three-dimensional CT ventriculography: a new application of helical CT AJR Am J Roentgenol 174 203–8 Occurrence Handle10628479 Occurrence Handle1:STN:280:DC%2BD3c%2Fpt1Slsg%3D%3D

    PubMed  CAS  Google Scholar 

  8. AF Kopp M Heuschmid A Reimann A Kuettner M Heuschnid AF Kopp et al. (2005) ArticleTitleEvaluation of cardiac function and myocardial viability with 16- and 64-slice multidetector computed tomography Eur Radiol 15 IssueIDSuppl 4 D15–20 Occurrence Handle16479639

    PubMed  Google Scholar 

  9. H Higashino T Mochizuki T Haraikawa A Kurata T Kido S Nakata et al. (2006) ArticleTitleImage fusion of coronary tree and regional cardiac function image using multislice computed tomography Circ J 70 105–9 Occurrence Handle16377933 Occurrence Handle10.1253/circj.70.105

    Article  PubMed  Google Scholar 

  10. S Abbara RC Cury K Nieman V Reddy F Moselewski S Schmidt et al. (2005) ArticleTitleNoninvasive evaluation of cardiac veins with 16-MDCT angiography AJR Am J Roentgenol 185 1001–6 Occurrence Handle16177423 Occurrence Handle10.2214/AJR.04.1382

    Article  PubMed  Google Scholar 

  11. LM Boxt (2005) ArticleTitleCT of valvular heart disease Int J Cardiovasc Imaging 21 105–13 Occurrence Handle15915944 Occurrence Handle10.1007/s10554-004-5339-5

    Article  PubMed  Google Scholar 

  12. T Mochizuki K Murase H Higashino Y Koyama S Azemoto J Ikezoe (1999) ArticleTitleDemonstration of acute myocardial infarction by subsecond spiral computed tomography: early defect and delayed enhancement Circulation 99 2058–9 Occurrence Handle10209013 Occurrence Handle1:STN:280:DyaK1M3isFCisA%3D%3D

    PubMed  CAS  Google Scholar 

  13. Y Koyama H Matsuoka T Mochizuki H Higashino H Kawakami S Nakata et al. (2005) ArticleTitleAssessment of reperfused acute myocardial infarction with two-phase contrast-enhanced helical CT: prediction of left ventricular function and wall thickness Radiology 235 804–11 Occurrence Handle15833978

    PubMed  Google Scholar 

  14. JF Paul M Wartski C Caussin A Sigal-Cinqualbre B Lancelin et al. (2005) ArticleTitleLate defect on delayed contrast-enhanced multidetector row CT scans in the prediction of SPECT infarct size after reperfused acute myocardial infarction: initial experience Radiology 236 485–9 Occurrence Handle15972333

    PubMed  Google Scholar 

  15. A Kurata T Mochizuki Y Koyama T Haralkawa J Suzuki Y Shigematsu et al. (2005) ArticleTitleMyocardial perfusion imaging using adenosine triphosphate stress multi-slice spiral computed tomography: alternative to stress myocardial perfusion scintigraphy Circ J 69 55–7 Occurrence Handle10.1253/circj.69.550

    Article  Google Scholar 

  16. AH Mahnken R Koos M Katoh JE Wildberger E Spuentrup A Buecker et al. (2005) ArticleTitleAssessment of myocardial viability in reperfused acute myocardial infarction using 16-slice computed tomography in comparison to magnetic resonance imaging J Am Coll Cardiol 45 2042–7 Occurrence Handle15963407 Occurrence Handle10.1016/j.jacc.2005.03.035

    Article  PubMed  Google Scholar 

  17. AC Lardo MA Cordeiro C Silva LC Amado RT George AP Saliaris et al. (2006) ArticleTitleContrast-enhanced multidetector computed tomography viability imaging after myocardial infarction: characterization of myocyte death, microvascular obstruction, and chronic scar Circulation 113 394–404 Occurrence Handle16432071 Occurrence Handle10.1161/CIRCULATIONAHA.105.521450

    Article  PubMed  Google Scholar 

  18. S Mori C Kondo N Suzuki H Yamashita A Hattori M Kusakabe et al. (2005) ArticleTitleVolumetric cine imaging for cardiovascular circulation using prototype 256-detector row computed tomography scanner (4-dimensional computed tomography): a preliminary study with a porcine model J Comput Assist Tomogr 29 26–30 Occurrence Handle15665678 Occurrence Handle10.1097/01.rct.0000151189.80473.2e

    Article  PubMed  Google Scholar 

  19. C Kondo S Mori M Endo K Kusakabe N Suzuki A Hattori et al. (2005) ArticleTitleReal-time volumetric imaging of human heart without electrocardiographic gating by 256-detector row computed tomography: initial experience J Comput Assist Tomogr 29 694–8 Occurrence Handle16163045 Occurrence Handle10.1097/01.rct.0000173844.89988.37

    Article  PubMed  Google Scholar 

  20. TG Flohr CH McCollough H Bruder M Petersilka K Gruber C Sus et al. (2006) ArticleTitleFirst performance evaluation of a dual-source CT (DSCT) system Eur Radiol 16 256–68 Occurrence Handle16341833 Occurrence Handle10.1007/s00330-005-2919-2

    Article  PubMed  Google Scholar 

  21. S Achenbach D Ropers A Kuettner T Flohr B Ohnesorge H Bruder et al. (2006) ArticleTitleContrast-enhanced coronary artery visualization by dual-source computed tomography—initial experience Eur J Radiol 57 331–5 Occurrence Handle16426789 Occurrence Handle10.1016/j.ejrad.2005.12.017

    Article  PubMed  Google Scholar 

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Correspondence to Teruhito Mochizuki.

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Kido, T., Kurata, A., Higashino, H. et al. Cardiac imaging using 256-detector row four-dimensional CT: preliminary clinical report. Radiat Med 25, 38–44 (2007).

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Key words

  • Coronary artery
  • Multislice CT
  • Cardiac function