Abstract
We report the aggressive clinical course of a giant cell tumor (GCT) arising from thoracic vertebra after slow growth for 7 years without treatment. GCTs of bone usually have the characteristics of local recurrence and a low potential for distant metastasis. The patient was a 37-year-old man with an unresectable large tumor of the mediastinum. The histopathological diagnosis of a biopsy specimen was GCT. He had received no treatment for 7 years after the initial diagnosis because the growth rate of the tumor was very slow. However, the tumor at the primary site then rapidly increased in size, and numerous multiple bone metastases developed despite radiotherapy for the primary tumor. These aggressive bone metastases with small numerous radiolucent lesions are rare.
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References
CJ Bennett SuffixJr RB Marcus SuffixJr RR Million WF Enneking (1993) ArticleTitleRadiation therapy for giant cell tumor of bone Int J Radiat Oncol Biol Phys 26 299–304 Occurrence Handle8491687
JJ Caudell MT Ballo GK Zagars VO Lewis KL Weber PP Lin et al. (2003) ArticleTitleRadiotherapy in the management of giant cell tumor of bone Int J Radiat Oncol Biol Phys 57 158–65 Occurrence Handle12909228 Occurrence Handle10.1016/S0360-3016(03)00416-4
H Sakurai N Mitsuhashi K Hayakawa H Niibe (1999) ArticleTitleGiant cell tumor of the thoracic spine simulating mediastinal neoplasm AJNR Am J Neuroradiol 20 1723–6 Occurrence Handle10543648 Occurrence Handle1:STN:280:DC%2BD3c%2FgvV2qsQ%3D%3D
RM Singhal S Mukhopadhyay RK Tanwar GS Pant PK Julka (1994) ArticleTitleCase report: giant cell tumour of metacarpals: report of three cases Br J Radiol 67 408–10 Occurrence Handle8173887 Occurrence Handle1:STN:280:DyaK2c3ivVagtg%3D%3D Occurrence Handle10.1259/0007-1285-67-796-408
MJ Seider TA Rich AG Ayala JA Murray (1986) ArticleTitleGiant cell tumors of bone: treatment with radiation therapy Radiology 161 537–40 Occurrence Handle3763928 Occurrence Handle1:STN:280:DyaL2s%2FhslOgtQ%3D%3D
M Campanacci N Baldini S Boriani A Sudanese (1987) ArticleTitleGiant-cell tumor of bone J Bone Joint Surg Am 69 106–14 Occurrence Handle3805057 Occurrence Handle1:STN:280:DyaL2s7gvFemtw%3D%3D
BKS Sanjay DA Younge (1996) ArticleTitleGiant cell tumour of metacarpal with pulmonary and skeletal metastases J Hand Surg [Br] 21 126–32 Occurrence Handle1:STN:280:DyaK283ksVSntQ%3D%3D Occurrence Handle10.1016/S0266-7681(96)80028-3
RR Goldenberg CJ Campbell M Bonfiglio (1970) ArticleTitleGiant-cell tumor of bone: an analysis of 218 cases J Bone Joint Surg Am 52 619–63 Occurrence Handle5479455 Occurrence Handle1:STN:280:DyaE3M%2Fjt1yktg%3D%3D
HW Sung DP Kuo WP Shu YB Chai CC Liu SM Li (1982) ArticleTitleGiant-cell tumor of bone: analysis of two hundred and eight cases in Chinese patients J Bone Joint Surg Am 64 755–61 Occurrence Handle7045129 Occurrence Handle1:STN:280:DyaL383hsVWitg%3D%3D
M De Smedt G Copin C Boeri JC Dosch M Dupuis L Marcellin (1999) ArticleTitleA case of a aggressive giant-cell tumor with multiple bone metastases Rev Chir Orthop Reparatrice Appar Mot 85 293–6 Occurrence Handle10422135 Occurrence Handle1:STN:280:DyaK1MzltFSgtw%3D%3D
Larsson S, Lorentzon R, Boquist L. Giant-cell tumor of bone. J Bone Joint Surg Am 57:167–73
A Mondal R Kundu DK Misra (2001) ArticleTitleFactors regulating the metastatic potential of benign giant cell tumour of bone-study of an unusual case with short review of literature Indian J Pathol Microbiol 44 31–5 Occurrence Handle12561992 Occurrence Handle1:STN:280:DC%2BD3s%2Flt1Shuw%3D%3D
JS Fain KK Unni JW Beabout MG Rock (1993) ArticleTitleNonepiphyseal giant cell tumor of the long bones: clinical, radiologic, and pathologic study Cancer 71 3514–9 Occurrence Handle8490899 Occurrence Handle1:STN:280:DyaK3s3lvVOhtA%3D%3D Occurrence Handle10.1002/1097-0142(19930601)71:11<3514::AID-CNCR2820711109>3.0.CO;2-A
CA Cummins MT Scarborough WF Enneking (1996) ArticleTitleMulticentric giant cell tumor of bone Clin Orthop 322 245–52 Occurrence Handle8542701 Occurrence Handle10.1097/00003086-199601000-00029
DC Dahlin RE Cupps EW Johnson SuffixJr (1970) ArticleTitleGiant cell tumor: a study of 195 cases Cancer 25 1061–70 Occurrence Handle4910256 Occurrence Handle1:STN:280:DyaE3c7otF2gsA%3D%3D Occurrence Handle10.1002/1097-0142(197005)25:5<1061::AID-CNCR2820250509>3.0.CO;2-E
S Malone B O'Sullivan C Catton R Bell V Fornasier A Davis (1995) ArticleTitleLong-term follow-up of efficacy and safety of megavoltage radiotherapy in high-risk giant cell tumors of bone Int J Radiat Oncol Biol Phys 33 689–94 Occurrence Handle7558960 Occurrence Handle1:STN:280:DyaK28%2FislOrsQ%3D%3D Occurrence Handle10.1016/0360-3016(95)00159-V
RS Bell AR Harwood SB Goodman VL Fornasier (1983) ArticleTitleSupervoltage radiotherapy in the treatment of difficult giant cell tumors of bone Clin Orthop Relat Res 174 208–16 Occurrence Handle6403271
I Ikeda S Itoh Y Nakamura T Takahashi H Niibe (1991) ArticleTitleRadiation therapy for giant cell tumor of bone: four young female patients J Jpn Soc Ther Radiol Oncol 3 231–8
L Miszczyk J Wydmański J Spindel (2001) ArticleTitleEfficacy of radiotherapy for giant cell tumor of bone: given either postoperatively or as sole treatment Int J Radiat Oncol Biol Phys 49 1239–42 Occurrence Handle11286829 Occurrence Handle1:STN:280:DC%2BD3M3hsl2rsA%3D%3D Occurrence Handle10.1016/S0360-3016(00)01520-0
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Takahashi, T., Katano, S., Ishikawa, H. et al. Aggressive clinical course of giant cell tumor arising from thoracic vertebra after a long latent period. Radiat Med 24, 534–537 (2006). https://doi.org/10.1007/s11604-006-0064-8
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DOI: https://doi.org/10.1007/s11604-006-0064-8