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Roles of MT-ND1 in Cancer

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Abstract

The energy shift toward glycolysis is one of the hallmarks of cancer. Complex I is a vital enzyme complex necessary for oxidative phosphorylation. The mitochondrially encoded NADH: ubiquinone oxidoreductase core subunit 1 (MT-ND1) is the largest subunit coded by mitochondria of complex I. The present study summarizes the structure and biological function of MT-ND1. From databases and literature, the expressions and mutations of MT-ND1 in a variety of cancers have been reviewed. MT-ND1 may be a biomarker for cancer diagnosis and prognosis. It is also a potential target for cancer therapy.

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Authors and Affiliations

  1. Department of Pathology, Shanghai Tongji Hospital, Tongji Hospital Affiliated to Tongji University, Shanghai, 200065, China

    Yi-chun Xu, Jun Su, Jia-jing Zhou, Qing Yuan & Jun-song Han

  2. National Engineering Research Center for Biochip, Shanghai Biochip Limited Corporation, Shanghai, 201203, China

    Yi-chun Xu, Jun Su & Jun-song Han

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  1. Yi-chun Xu
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  2. Jun Su
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  3. Jia-jing Zhou
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Correspondence to Yi-chun Xu or Jun-song Han.

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The authors declare that there is no conflict of interest with any financial organization or corporation or individual that can inappropriately influence this work.

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The present study was supported by National Natural Science Foundation of China (No. 82203232), Scientific Instrument Field Project of Shanghai Science and Technology Commission (No. 22142202700) and Shanghai Rising-Star Program (No. 19QB1404700).

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Xu, Yc., Su, J., Zhou, Jj. et al. Roles of MT-ND1 in Cancer. CURR MED SCI 43, 869–878 (2023). https://doi.org/10.1007/s11596-023-2771-0

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