Abstract
Objective
The National Natural Science Foundation of China (NSFC) has made great progress in promoting the development of aortic dissection research in recent years. This study aimed to examine the development and research status of aortic dissection research in China so as to provide references for future research.
Methods
The NSFC projects data from 2008 to 2019 were collected from the Internet-based Science Information System and other websites utilized as search engines. The publications and citations were retrieved by Google Scholar, and the impact factors were checked by the InCite Journal Citation Reports database. The investigator’s degree and department were identified from the institutional faculty profiles.
Results
A total of 250 grant funds totaling 124.3 million Yuan and resulting in 747 publications were analyzed. The funds in economically developed and densely populated areas were more than those in underdeveloped and sparsely populated areas. There was no significant difference in the amount of funding per grant between different departments’ investigators. However, the funding output ratios of the grants for cardiologists were higher than those for basic science investigators. The amount of funding for clinical researchers and basic scientific researchers in aortic dissection was also similar. Clinical researchers were better in terms of the funding output ratio.
Conclusion
These results suggest that the medical and scientific research level of aortic dissection in China has been greatly improved. However, there are still some problems that urgently need to be solved, such as the unreasonable regional allocation of medical and scientific research resources, and the slow transition from basic science to clinical practice.
References
Pape LA, Awais M, Woznicki EM, et al. Presentation, Diagnosis, and Outcomes of Acute Aortic Dissection: 17-Year Trends From the International Registry of Acute Aortic Dissection. J Am Coll Cardiol, 2015,66(4):350-358
Evangelista A, Isselbacher EM, Bossone E, et al. Insights From the International Registry of Acute Aortic Dissection: A 20-Year Experience of Collaborative Clinical Research. Circulation, 2018,137(17):1846–1860
Yamaguchi T, Nakai M, Yano T, et al. Populationbased incidence and outcomes of acute aortic dissection in Japan. Eur Heart J Acute Cardiovasc Care, 2021,10(7):701–709
Sun L, Qi R, Zhu J, et al. Total arch replacement combined with stented elephant trunk implantation: a new “standard” therapy for type a dissection involving repair of the aortic arch? Circulation, 2011,123(9):971-97
Bossone E, Pyeritz RE, O’Gara P, et al. Acute aortic dissection in blacks: insights from the International Registry of Acute Aortic Dissection. Am J Med, 2013,126(10):909–915
Sun LZ, Li JR. Progress and challenge of Stanford type A aortic dissection in China. Zhonghua Wai Ke Za Zhi (Chinese), 2017,55(4):241–244
Liu Y, Gao Z, Wang H, et al. Analysis of projects funded by the National Natural Science Foundation of China during the years of 2014–2018. Ann Transl Med, 2019,7(12):267
Su Y, Li Q, Zheng Z, et al. Integrative bioinformatics analysis of miRNA and mRNA expression profiles and identification of associated miRNA-mRNA network in aortic dissection. Medicine (Baltimore), 2019,98(24):e16013
Sbarouni E, Georgiadou P. MicroRNAs in acute aortic dissection. J Thorac Dis, 2018,10(3):1256–1257
Yu Y, Shi E, Gu T, et al. Overexpression of microRNA-30a contributes to the development of aortic dissection by targeting lysyl oxidase. J Thorac Cardiovasc Surg, 2017,154(6):1862–1869
Zampetaki A, Attia R, Mayr U, et al. Role of miR-195 in aortic aneurysmal disease. Circ Res, 2014,115(10):857–866
Maegdefessel L, Azuma J, Toh R, et al. MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion. Sci Transl Med, 2012,4(122):122r
Merk DR, Chin JT, Dake BA, et al. miR-29b participates in early aneurysm development in Marfan syndrome. Circ Res, 2012,110(2):312–324
van de Laar IM, Oldenburg RA, Pals G, et al. Mutations in SMAD3 cause a syndromic form of aortic aneurysms and dissections with early-onset osteoarthritis. Nat Genet, 2011,43(2):121–126
Loeys BL, Chen J, Neptune ER, et al. A syndrome of altered cardiovascular, craniofacial, neurocognitive and skeletal development caused by mutations in TGFBR1 or TGFBR2. Nat Genet, 2005,37(3):275–281
Ye P, Chen W, Wu J, et al. GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency. J Clin Invest, 2013,123(5):2317–2331
Huang X, Yue Z, Wu J, et al. MicroRNA-21 Knockout Exacerbates Angiotensin II-Induced Thoracic Aortic Aneurysm and Dissection in Mice With Abnormal Transforming Growth Factor-beta-SMAD3 Signaling. Arterioscler Thromb Vasc Biol, 2018,38(5):1086–1101
Lacro RV, Dietz HC, Sleeper LA, et al. Atenolol versus losartan in children and young adults with Marfan’s syndrome. N Engl J Med, 2014,371(22):2061–2071
Gao L, Chen L, Fan L, et al. The effect of losartan on progressive aortic dilatation in patients with Marfan’s syndrome: a meta-analysis of prospective randomized clinical trials. Int J Cardiol, 2016,217190–194
Acknowledgements
The authors would like to thank Dr. John S. for the language help.
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
The authors have no conflicts of interest to declare.
Additional information
This work was supported by the National Natural Science Foundation of China (No. 81800413 and No. 81974048).
Rights and permissions
About this article
Cite this article
Yue, Z., Wang, Ds., Le, S. et al. Aortic Dissection Research in China: Analysis of Studies Funded by the National Natural Science Foundation of China. CURR MED SCI 43, 206–212 (2023). https://doi.org/10.1007/s11596-022-2662-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11596-022-2662-9