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CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children

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Abstract

Objective

Gliomas are the most common tumors in the central nervous system. The cancer susceptibility candidate 15 (CASC15) gene has been reported to be a susceptibility gene for several types of cancer. No studies have been carried out on the predisposing effect of CASC15 gene single nucleotide polymorphisms (SNPs) on glioma risk.

Methods

In order to determine whether CASC15 gene SNPs are involved in glioma susceptibility, the first association study in a relatively large sample, which consisted of 171 patients and 228 healthy controls recruited from China, was performed. The contribution of SNPs (rs6939340 A>G, rs4712653 T>C and rs9295536 C>A) to the risk of glioma was evaluated by multinomial logistic regression, based on the calculation of the odds ratio (OR) and 95% confidence interval (CI).

Results

In the single locus and combined analysis, it was revealed that the genetic risk score had no significant associations between CASC15 gene SNPs and glioma risk. However, in the stratified analysis, a significant decrease in risk of glioma was observed in subjects of <60 months old with the rs4712653 TT genotype, when compared to those with the CC/CT genotype (OR=0.12, 95% CI=0.02–0.91, P=0.041).

Conclusion

The present study provides referential evidence on the association between the genetic predisposition of the CASC15 gene and glioma risk in Chinese children. However, more well-designed case-control studies and functional experiments are needed to further explore the role of CASC15 gene SNPs.

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Authors and Affiliations

  1. Faculty of Medicine, Macau University of Science and Technology, Macau, 999078, China

    Hui-ran Lin

  2. Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangdong Provincial Key Laboratory of Research in Structural Birth Defect Disease, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, China

    Yong-ping Chen, Hui-tong Chen & Zhen-jian Zhuo

  3. Department of Hematology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, 510623, China

    Xiao-ping Liu

  4. Department of Hematology, the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, Wenzhou, 325027, China

    Jing-ying Zhou & Xiao-kai Huang

  5. Department of Pathology, Guangzhou Women and Children’s Medical Center, Guangzhou, 510623, China

    Li Yuan

Authors
  1. Hui-ran Lin
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  2. Yong-ping Chen
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  3. Hui-tong Chen
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  4. Xiao-ping Liu
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  6. Xiao-kai Huang
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  7. Li Yuan
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  8. Zhen-jian Zhuo
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Corresponding authors

Correspondence to Li Yuan or Zhen-jian Zhuo.

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The authors declare that they have no conflict of interest.

Additional information

This work was funded by grants from the Natural Science Foundation of Guangdong Province (No. 2020A1515010188), the National Natural Science Foundation of China (Nos. 81802346 and 81672496), and the Science and Technology Project of Guangzhou (No. 201804010042).

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Lin, Hr., Chen, Yp., Chen, Ht. et al. CASC15 Gene Polymorphisms and Glioma Susceptibility in Chinese Children. CURR MED SCI 42, 797–802 (2022). https://doi.org/10.1007/s11596-022-2613-5

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  • DOI: https://doi.org/10.1007/s11596-022-2613-5

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