Skip to main content
SpringerLink
Log in

Clinical Analysis of Primary Tracheobronchial Tumors in Children and Evaluation of the Predicting Models for Mucoepidermoid Carcinoma

  • Published:
Current Medical Science Aims and scope Submit manuscript

Abstract

Objective

To determine the clinical characteristics and prognosis of primary tracheobronchial tumors (PTTs) in children, and to explore the most common tumor identification methods.

Methods

The medical records of children with PTTs who were hospitalized at the Children’s Hospital of Chongqing Medical University from January 1995 to January 2020 were reviewed retrospectively. The clinical features, imaging, treatments, and outcomes of these patients were statistically analyzed. Machine learning techniques such as Gaussian naïve Bayes, support vector machine (SVM) and decision tree models were used to identify mucoepidermoid carcinoma (ME).

Results

A total of 16 children were hospitalized with PTTs during the study period. This included 5 (31.3%) children with ME, 3 (18.8%) children with inflammatory myofibroblastic tumors (IMT), 2 children (12.5%) with sarcomas, 2 (12.5%) children with papillomatosis and 1 child (6.3%) each with carcinoid carcinoma, adenoid cystic carcinoma (ACC), hemangioma, and schwannoma, respectively. ME was the most common tumor type and amongst the 3 ME recognition methods, the SVM model showed the best performance. The main clinical symptoms of PPTs were cough (81.3%), breathlessness (50%), wheezing (43.8%), progressive dyspnea (37.5%), hemoptysis (37.5%), and fever (25%). Of the 16 patients, 7 were treated with surgery, 8 underwent bronchoscopic tumor resection, and 1 child died. Of the 11 other children, 3 experienced recurrence, and the last 8 remained disease-free. No deaths were observed during the follow-up period.

Conclusion

PTT are very rare in children and the highest percentage of cases is due to ME. The SVM model was highly accurate in identifying ME. Chest CT and bronchoscopy can effectively diagnose PTTs. Surgery and bronchoscopic intervention can both achieve good clinical results and the prognosis of the 11 children that were followed up was good.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Eyssartier E, Ang P, Bonnemaison E, et al. Characteristics of endobronchial primitive tumors in children. Pediatr Pulmonol, 2014,49(6):E121–E125

    Article  CAS  Google Scholar 

  2. Xu LT, Sun ZF, Li ZJ, et al. Clinical and pathologic characteristics in patients with tracheobronchial tumor: report of 50 patients. Ann Thorac Surg, 1987,43(3):276–278

    Article  CAS  Google Scholar 

  3. Kleihues P, Sobin LH. World Health Organization classification of tumors. Cancer, 2015,88(12):2887

    Article  Google Scholar 

  4. Ishizumi T, Tateishi U, Watanabe SI, et al. F-18 FDG PET/CT imaging of low-grade mucoepidermoid carcinoma of the bronchus. Ann Nuclear Med, 2007, 21(5):299–302

    Article  Google Scholar 

  5. Scott KJ, Darrow D, Greinwald JH, et al. Endobronchial Tumors in Children: An Uncommon Clinical Entity. Ann Otol Rhinol Laryngol, 2001,110(1):63–69

    Article  CAS  Google Scholar 

  6. Yu Y, Song Z, Chen Z, et al. Chinese pediatric and adolescent primary tracheobronchial tumors: a hospital-based study. Pediatr Surg Int, 2011,27(7):721–726

    Article  Google Scholar 

  7. Varela P, Pio L, Torre M. Primary tracheobronchial tumors in children. Semin Pediatr Surg, 2016,25(3):150–155

    Article  Google Scholar 

  8. Varela P, Pio L, Brandigi E, et al. Tracheal and bronchial tumors. J Thorac Dis, 2016,8(12):3781–3786

    Article  Google Scholar 

  9. Wang HW, Zhang JL, Li DM, et al. Efficacy of Bronchoscopic Therapies for Bronchial Mucoepidermoid Carcinoma in Children: Results from Six Patients. Tumori, 2015,101(1):52–56

    Article  Google Scholar 

  10. Xu LT, Sun ZF, Li ZJ, et al. Tracheobronchial Tumors: An Eighteen-Year Series from Capital Hospital, Peking, China. Ann Thorac Surg, 1983,35(6):590–596

    Article  CAS  Google Scholar 

  11. Ma K, Sun FH, Yang XD, et al. Prognosis of patients with primary malignant main stem bronchial tumors: 7,418 cases based on the SEER database. Onco Targets Ther, 2018,11:83–95

    Article  Google Scholar 

  12. Techavichit P, Hicks MJ, López-Terrada, et al. Mucoepidermoid Carcinoma in Children: A Single Institutional Experience. Pediatr Blood Cancer, 2016, 63(1):27–31

    Article  CAS  Google Scholar 

  13. Cuestas G, Rodríguez V, Doormann F, et al. Tracheobronchial and pulmonary papillomatosis without involvement of the larynx treated with intravenous Bevacizumab in a child. Arch Argent Pediatr, 2019, 117(1):e72–e76

    PubMed  Google Scholar 

  14. Jindal A, Bal A, Agarwal R. Inflammatory myofibroblastic tumor of the trachea in the pediatric age group: case report and systematic review of the literature. J Bronchology Interv Pulmonol, 2015,22(1):58–65

    Article  Google Scholar 

  15. Butrynski JE, D’Adamo DR, Hornick JL, et al. Crizotinib in ALK-Rearranged Inflammatory Myofibroblastic Tumor. N Engl J Med, 2010,363(18):1727–1733

    Article  CAS  Google Scholar 

  16. Takeuchi K, Soda M, Togashi Y, et al. Pulmonary Inflammatory Myofibroblastic Tumor Expressing a Novel Fusion, PPFIBP1-ALK: Reappraisal of Anti-ALK Immunohistochemistry as a Tool for Novel ALK Fusion Identification. Clin Cancer Res, 2011,17(10):3341–3348

    Article  CAS  Google Scholar 

  17. Giannini L, Incandela F, Bresciani L, et al. Surgical treatment of primary tracheal tumors in children and adolescents. Pediatric Medicine, 2019,2:3–3

    Article  Google Scholar 

  18. Rojas Y, Shi YX, Zhang W, et al. Primary malignant pulmonary tumors in children: a review of the national cancer data base. J Pediatr Surg, 2015,50(6):1004–1008

    Article  Google Scholar 

  19. Jaramillo S, Rojas Y, Slater BJ, et al. Childhood and adolescent tracheobronchial mucoepidermoid carcinoma (MEC): a case-series and review of the literature. Pediatr Surg Int, 2016,32(4):417–424

    Article  Google Scholar 

  20. Ferguson MK, Landreneau RJ, Hazelrigg SR, et al. Long-term outcome after resection for bronchial carcinoid tumors. Eur J Cardiothorac Surg, 2000,18(2):156–161

    Article  CAS  Google Scholar 

  21. Romão RL, de Barros F, Maksoud Filho JG, et al. Malignant tumor of the trachea in children: diagnostic pitfalls and surgical management. J Pediatr Surg, 2009,44(11):e1–e4

    Article  Google Scholar 

  22. Molina JR, Aubry MC, Lewis JE, et al. Primary salivary gland-type lung cancer: Spectrum of clinical presentation, histopathologic and prognostic factors. Cancer, 2007,110(10):2253–2259

    Article  Google Scholar 

  23. Song Z, Liu Z, Wang J, et al. Primary tracheobronchial mucoepidermoid carcinoma — a retrospective study of 32 patients. World J Surg Oncol, 2013,11(1):62

    Article  Google Scholar 

  24. Fortes HR, Ranke FV, Escuissato DL, et al. Recurrent respiratory papillomatosis: A state-of-the-art review. Respir Med, 2017,126(2017):116–121

    Article  Google Scholar 

  25. Al-Qahtani AR, Lorenzo MD, Yazbeck S. Endobronchial tumors in children: Institutional experience and literature review. J Pediatr Surg, 2003,38(5):733–736

    Article  Google Scholar 

  26. Desai DP, Holinger LD, Gonzalez-Crussi F. Tracheal Neoplasms in Children. Ann Otol Rhinol Laryngol, 1998,107(9 Pt 1):790–796

    Article  CAS  Google Scholar 

  27. Mamoru T, Takahumi Y, Yuki M, et al. A case of tracheal pleomorphic adenoma misdiagnosed as asthma. Oxf Med Case Reports, 2019,11(2019):457–460

    Google Scholar 

Download references

Acknowledgments

We thank Mr. Yang SHU of Chengdu University of Chinese Medicine for his guidance on statistical analysis.

Author information

Author notes

  1. The authors contributed equally to this work.

Authors and Affiliations

  1. Department of Pulmonology, Children’s Hospital of Chongqing Medical University, Chongqing, 400014, China

    Chen Zhang, Wen-long Fu, Ji-hong Dai, Yong-gang Li, Xing-ye Tang, Xiao-feng Ma, Gang Geng, Ying Li, Ting Yang, Li Yan, Jing-yue Liu, Zheng Liu, Xiao-ping Yuan & Dai-yin Tian

  2. Department of Pediatrics, Chongqing Fifth People’s Hospital, Chongqing, 400014, China

    Chen Zhang

Authors
  1. Chen Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Wen-long Fu
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Ji-hong Dai
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yong-gang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Xing-ye Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Xiao-feng Ma
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Gang Geng
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Ying Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Ting Yang
    View author publications

    You can also search for this author in PubMed Google Scholar

  10. Li Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  11. Jing-yue Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  12. Zheng Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  13. Xiao-ping Yuan
    View author publications

    You can also search for this author in PubMed Google Scholar

  14. Dai-yin Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Dai-yin Tian.

Ethics declarations

The authors have no conflicts of interest related to this study.

Additional information

This study was supported by the Chongqing Science and Health Joint Medical Research Project (No. 8187011078).

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhang, C., Fu, Wl., Dai, Jh. et al. Clinical Analysis of Primary Tracheobronchial Tumors in Children and Evaluation of the Predicting Models for Mucoepidermoid Carcinoma. CURR MED SCI 42, 778–784 (2022). https://doi.org/10.1007/s11596-022-2595-3

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11596-022-2595-3

Key words

Search

Navigation