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Diagnostic Value of Circulating PIGF in Combination with Flt-1 in Early Cervical Cancer

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Summary

The utility of placental growth factor (PlGF) and its receptor VEGFR-1 (Flt-1) as biomarkers for cervical cancer has not been clarified yet. To address this issue, we investigated the levels of soluble PlGF (sPlGF) and soluble Flt-1 (sFlt-1) in the serum from patients with early cervical cancer, cervical intraepithelial neoplasia (CIN) and controls in this study. sPlGF and sFlt-1 were detected in 44 preoperative patients with cervical cancer, 18 cases with CIN, and 20 controls by ELISA. It was found that both sPlGF and sFlt-1 were significantly increased in the cervical cancer group as compared with those in CIN and control groups. sPlGF presented a high diagnostic ability of cervical cancer, with a sensitivity of 61.36% and a specificity of 89.47%; and sFlt-1 with a sensitivity of 50.00% and a specificity of 92.11%. Importantly, the combined use of sPlGF and sFlt-1 could increase the diagnostic rate of cervical cancer, with a sensitivity of 70.45% and a specificity of 92.11%. These results indicated that both sPlGF and sFlt-1 in circulation can serve as possible valuable diagnostic biomarkers for cervical cancer, and the combined use of them can be more valuable to diagnose the patients with early cervical cancer.

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  1. The authors contributed equally to this work.

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Shou-hua Yang, Xiao-ling Wang, Jing Cai & Shao-hai Wang

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  1. Shou-hua Yang
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  2. Xiao-ling Wang
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  3. Jing Cai
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  4. Shao-hai Wang
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Corresponding author

Correspondence to Shao-hai Wang.

Additional information

This work was supported by the National Natural Science Foundation of China (No. 81202063).

Conflict of Interest Statement

The authors have no conflict of interest.

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Yang, Sh., Wang, Xl., Cai, J. et al. Diagnostic Value of Circulating PIGF in Combination with Flt-1 in Early Cervical Cancer. CURR MED SCI 40, 973–978 (2020). https://doi.org/10.1007/s11596-020-2269-y

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  • DOI: https://doi.org/10.1007/s11596-020-2269-y

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