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Mapping Changes of Whole Brain Blood Flow in Rats with Myocardial Ischemia/Reperfusion Injury Assessed by Positron Emission Tomography

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Summary

18F-labeled fluorodeoxyglucose positron emission tomography (18F-FDG PET) is the most sensitive tool for studying brain metabolism in vivo. We investigated the image patterns of 18F-FDG PET during reperfusion injury and correlated changes of whole brain blood flow utilizing a rat myocardial ischemia/reperfusion injury (MIRI) model. The results assessed by echocardiography indicated resultant cardiac dysfunction after ischemia-reperfusion in the rat heart. It was found that the average standardized uptake value (SUVaverage) of the whole brain was significantly decreased in model rats, and the glucose uptake of different brain regions including accumbens core/shell (Acb), left caudate putamen (LCPu), hippocampus (HIP), left hypothalamus (LHYP), olfactory (OLF), superior colliculus (SC), right midbrain (RMID), ventral tegmental area (VTA), inferior colliculus (IC) and left thalamus whole (LTHA) was significantly decreased in MIRI rats whereas no significant difference was found in the SUVaverage of amygdala (AMY), right CPu, RHYP, right HYP, left MID, right THA, pons and medulla oblongata (MO). These 18F-FDG PET data provide a reliable identification method for brain metabolic changes in rats with MIRI.

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Author information

Authors and Affiliations

  1. Medical Association of Hubei Province, Wuhan, 430071, China

    Xu-chu Pan & Yong-tang Song

  2. Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Zhi-xiao Li & Hong-bing Xiang

  3. Department of Anesthesiology, Hainan General Hospital, Haikou, 570311, China

    Duo-zhi Wu

  4. Department of Anesthesiology, the First Affiliated Quanzhou Hospital of Fujian Medical University, Quanzhou, 362000, China

    Shun-yuan Li

Authors
  1. Xu-chu Pan
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  2. Zhi-xiao Li
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  3. Duo-zhi Wu
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Corresponding authors

Correspondence to Xu-chu Pan or Yong-tang Song.

Additional information

This project was supported by grants from National Natural Science Foundation of China (No. 81670240 and No. 81873467), National Natural Science Foundation of Hubei Province (No. 2016CFB625), Medical Innovation Project in Fujian Province (No. 2017-CX-48), and Key Research and Development Project of Hainan Province of China (No. ZDYF2018115).

Conflict of Interest Statement

The authors have no conflicts of interest related to this paper.

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Pan, Xc., Li, Zx., Wu, Dz. et al. Mapping Changes of Whole Brain Blood Flow in Rats with Myocardial Ischemia/Reperfusion Injury Assessed by Positron Emission Tomography. CURR MED SCI 39, 653–657 (2019). https://doi.org/10.1007/s11596-019-2087-2

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  • DOI: https://doi.org/10.1007/s11596-019-2087-2

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