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Whole Body Positron Emission Tomography/Computed Tomography (PET/CT) in the Evaluation of Ophthalmic Tumors

Summary

The clinical value of whole body positron emission tomography/computed tomography (PET/CT) as an imaging tool in diagnosis of ophthalmic tumors was investigated. The retrospective observational case series were performed on the patients with suspected ophthalmic tumors who underwent whole body PET/CT. The golden standard of diagnosis was the final pathological diagnosis or the results of long-term follow-up for patients without surgery/biopsy. PET/CT findings were compared with the golden standard. The sensitivity, specificity, accuracy and positive likelihood ratio of PET/CT in the detection of ophthalmic tumors were calculated. The clinical application of PET/CT in different types of ophthalmic tumors was evaluated. The results showed that 30 patients (18 males and 12 females) with a mean age of 43.0 years (range 4–63 years) were collected. The mean sizes of orbital tumors and intraocular tumors were 26.8 mm×17.8 mm and 11.2 mm×6.1 mm, respectively. The overall sensitivity, specificity, accuracy and positive likelihood ratio of whole body PET/CT in ophthalmic tumors were 76.5%, 71.4%, 75.0% and 2.67, and were 62.5%, 100% and 70.0% in intraocular tumors, and those were 100%, 60.0% and 84.6% in orbital tumors, respectively. PET/CT findings were applied to help make appropriate treatment options in 27 out of 30 patients (90.0%), and 12 (40.0%) patients changed the treatment strategy. False negative results in 4 cases and false positive results in 2 cases were observed in this series. It was suggested that PET/CT was an effective imaging modality in detecting, diagnosing and developing therapeutic schedule for patients with ophthalmic tumors. It was more sensitive and accurate for detecting orbital tumors than for detecting intraocular tumors.

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References

  1. 1

    Endo K, Oriuchi N, Higuchi T, et al. PET and PET/CT using 18F-FDG in the diagnosis and management of cancer patients. Int J Clin Oncol, 2006,11(4):286–296

    Article  PubMed  Google Scholar 

  2. 2

    Poeppel TD, Krause BJ, Heusner TA, et al. PET/ CT for the staging and follow-up of patients with malignancies. Eur J Radiol, 2009,70(3):382–392

    Article  PubMed  CAS  Google Scholar 

  3. 3

    Sachelarie I, Kerr K, Ghesani M, et al. Integrated PET-CT: evidence-based review of oncology indications. Oncology (Williston Park), 2005,19(4):481–490

    Google Scholar 

  4. 4

    Roe RH, Finger PT, Kurli M, et al. Whole-body positron emission tomography/computed tomography imaging and staging of orbital lymphoma. Ophthalmology, 2006,113(10):1854–1858

    Article  PubMed  Google Scholar 

  5. 5

    Finger PT, Chin KJ. [(18)F]Fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) physiologic imaging of choroidal melanoma: before and after ophthalmic plaque radiation therapy. Int J Radiat Oncol Biol Phys, 2011,79(1):137–142

    Article  PubMed  Google Scholar 

  6. 6

    Finger PT, Kurli M, Reddy S, et al. Whole body PET/ CT for initial staging of choroidal melanoma. Br J Ophthalmol, 2005,89(10):1270–1274

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  7. 7

    Radhakrishnan V, Kumar R, Malhotra A, et al. Role of PET/CT in staging and evaluation of treatment response after 3 cycles of chemotherapy in locally advanced retinoblastoma: a prospective study. J Nucl Med, 2012,53(2):191–198

    Article  PubMed  CAS  Google Scholar 

  8. 8

    Matsuo T, Ogino Y, Ichimura K, et al. Clinicopathological correlation for the role of fluorodeoxyglucose positron emission tomography computed tomography in detection of choroidal malignant melanoma. Int J Clin Oncol, 2014,19(2):230–239

    Article  PubMed  Google Scholar 

  9. 9

    Reddy S, Kurli M, Tena LB, et al. PET/CT imaging: detection of choroidal melanoma. Br J Ophthalmol, 2005,89(10):1265–1269

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  10. 10

    Faia LJ, Pulido JS, Donaldson MJ, et al. The relationship between combined positron emission tomography/computed tomography and clinical and light microscopic findings in choroidal melanoma. Retina, 2008,28(5):763–769

    Article  PubMed  Google Scholar 

  11. 11

    Papastefanou VP, Islam S, Szyszko T, et al. Metabolic activity of primary uveal melanoma on PET/CT scan and its relationship with monosomy 3 and other prognostic factors. Br J Ophthalmol, 2014,98(12):1659–1665

    Article  PubMed  PubMed Central  Google Scholar 

  12. 12

    Finger PT, Chin K, Iacob CE. 18-Fluorine-labelled 2-deoxy-2-fluoro-D-glucose positron emission tomography/computed tomography standardised uptake values: a non-invasive biomarker for the risk of metastasis from choroidal melanoma. Br J Ophthalmol, 2006,90(10):1263–1266

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  13. 13

    Calcagni ML, Mattoli MV, Blasi MA, et al. A prospective analysis of (1)(8)F-FDG PET/CT in patients with uveal melanoma: comparison between metabolic rate of glucose (MRglu) and standardized uptake value (SUV) and correlations with histopathological features. Eur J Nucl Med Mol Imaging, 2013,40(11):1682–1691

    Article  PubMed  CAS  Google Scholar 

  14. 14

    McCannel TA, Reddy S, Burgess BL, et al. Association of positive dual-modality positron emission tomography/computed tomography imaging of primary choroidal melanoma with chromosome 3 loss and tumor size. Retina, 2010,30(1):146–151

    Article  PubMed  Google Scholar 

  15. 15

    Patel P, Finger PT. Whole-body 18F FDG positron emission tomography/computed tomography evaluation of patients with uveal metastasis. Am J Ophthalmol, 2012,153(4):661–668

    Article  PubMed  Google Scholar 

  16. 16

    Gupta S, Bhatt VR, Varma S. Unilateral orbital pain and eyelid swelling in a 46-year-old woman: orbital metastasis of occult invasive lobular carcinoma of breast masquerading orbital pseudotumour. BMJ Case Rep, 2011,2011

    Google Scholar 

  17. 17

    Kubota R, Yamada S, Kubota K, et al. Intratumoral distribution of fluorine-18-fluorodeoxyglucose in vivo: high accumulation in macrophages and granulation tissues studied by microautoradiography. J Nucl Med, 1992,33(11):1972–1980

    PubMed  CAS  Google Scholar 

  18. 18

    Kim KS. Primary nasopharyngeal tuberculosis mimicking carcinoma: a potentially false-positive PET/CT finding. Clin Nucl Med, 2010,35(5):346–348

    Article  PubMed  Google Scholar 

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Correspondence to Fa-gang Jiang.

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Jiang, P., Liao, Ss., Lan, Xl. et al. Whole Body Positron Emission Tomography/Computed Tomography (PET/CT) in the Evaluation of Ophthalmic Tumors. CURR MED SCI 38, 310–317 (2018). https://doi.org/10.1007/s11596-018-1880-7

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Key words

  • positron emission tomography/computed tomography
  • ophthalmic tumor
  • orbital tumor
  • ocular tumor