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ω-3PUFAs prevent MK-801-induced cognitive impairment in schizophrenic rats via the CREB/BDNF/TrkB pathway

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Summary

This study was to determine the protective effect of ω-3 polyunsaturated fatty acids (ω-3PUFAs) on MK-801-induced cognitive impairment in schizophrenia (SZ) rats and the underlying mechanism. A rat model of schizophrenia was induced by MK-801. The cognitive function of rats was assessed using a Morris water maze. The number of hippocampal neurons was measured by Nissl staining. The expression of CREB, p-CREB, BDNF, TrkB, p-TrkB, AKT, p-AKT, ERK, and p-ERK in the hippocampus of rats was detected by Western blotting. The results showed that ω-3PUFAs attenuated MK-801-induced cognitive impairment and hippocampal neurons loss, reversed the injury of the CREB/BDNF/TrkB pathway induced by MK-801, and antagonized MK-801-induced down-regulation of p-AKT and p-ERK in the hippocampus of rats. In conclusion, ω-3PUFAs enhances the CREB/BDNF/TrkB pathway by activating ERK and AKT, thereby increasing the synaptic plasticity and decreasing neuron loss, and antagonizing MK-801-induced cognitive impairment in schizophrenic rats.

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Author notes

  1. The authors contributed equally to this work.

Authors and Affiliations

  1. Wuhan Mental Health Center, Wuhan, 430022, China

    Mao-sheng Fang  (房茂胜), Hong Qian  (钱 红), Kuan Zeng  (曾 宽), Meng Ye  (叶 萌), Yong-jie Zhou  (周勇杰), Hui Li  (李 辉) & Yi Li  (李 毅)

  2. Department of Pathophysiology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Xing Li  (李 行), Kuan Zeng  (曾 宽) & Xiao-chuan Wang  (王小川)

  3. Co-innovation Center of Neuroregeneration, Nantong, 226001, China

    Xiao-chuan Wang  (王小川)

Authors
  1. Mao-sheng Fang  (房茂胜)
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  2. Xing Li  (李 行)
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  3. Hong Qian  (钱 红)
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  4. Kuan Zeng  (曾 宽)
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  5. Meng Ye  (叶 萌)
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  6. Yong-jie Zhou  (周勇杰)
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  7. Hui Li  (李 辉)
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  8. Xiao-chuan Wang  (王小川)
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  9. Yi Li  (李 毅)
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Corresponding authors

Correspondence to Xiao-chuan Wang  (王小川) or Yi Li  (李 毅).

Additional information

This study was supported in parts by grants from the Hubei Province Key Technology R&D Program (No. 2015BCE094), Wuhan Science and Technology Bureau Dawn Plan Project (No. 201507040410216), Clinical Research Physician Program of Tongji Medical College, HUST and the Academic Frontier Youth Team Project of HUST.

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Fang, Ms., Li, X., Qian, H. et al. ω-3PUFAs prevent MK-801-induced cognitive impairment in schizophrenic rats via the CREB/BDNF/TrkB pathway. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 37, 491–495 (2017). https://doi.org/10.1007/s11596-017-1762-4

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  • DOI: https://doi.org/10.1007/s11596-017-1762-4

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